公开(公告)号：US20250028159A1

公开(公告)日：2025-01-23

申请号：US18712553

申请日：2022-11-23

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Shuyan ZHENG ,  Malini OLIVO

IPC: G02B21/12 ,  A61B1/04 ,  A61B1/07 ,  G01N21/64 ,  G02B21/16 ,  G02B21/26 ,  G02B21/36 ,  G02B27/14 ,  G02B27/30

Abstract: Embodiments of the invention provide for a multimodal microscopy system. The multimodal microscopy system may include an illumination module configured to provide a light beam to a sample under test via a delivery path; and an optical arrangement configured to receive the light beam from the sample through a detection path to generate a microscopy image of the sample. The optical arrangement may be operable to switch among a plurality of imaging modalities using the detection path shared by the plurality of imaging modalities. The plurality of imaging modalities may include brightfield microscopy, fluorescent microscopy, and endoscopic microscopy. The multimodal microscopy system may be a multimodal hyperspectral microscopy system.

公开(公告)号：US20160231337A1

公开(公告)日：2016-08-11

申请号：US15022362

申请日：2014-09-16

Applicant: NANYANG TECHNOLOGICAL UNIVERSITY ,  Agency for Science, Technology and Research

Inventor： Malini OLIVO ,  Kien Voon KONG ,  Weng Kee LEONG

IPC: G01N33/84 ,  G01N33/58 ,  C12Q1/26 ,  G01N21/65 ,  C12Q1/54

CPC classification number: G01N33/84 ,  B82Y15/00 ,  C01G55/008 ,  C12Q1/26 ,  C12Q1/54 ,  G01N21/658 ,  G01N33/587 ,  G01N2333/904

Abstract: A method of detecting one or more analytes comprising or consisting of hydrogen peroxide using surface enhanced Raman spectroscopy (SERS) is provided. The method includes providing a SERS-active substrate having at least one metal carbonyl cluster compound attached thereon; contacting one or more analytes with the SERS-active substrate; and detecting changes in surface enhanced Raman signal from the at least one metal carbonyl cluster compound as an indication of the presence of one or more analytes comprising or consisting of hydrogen peroxide.

Abstract translation: 提供了使用表面增强拉曼光谱（SERS）检测包含或由过氧化氢组成的一种或多种分析物的方法。 该方法包括提供其上附着至少一个金属羰基簇化合物的SERS-活性基底; 使一种或多种分析物与SERS活性底物接触; 以及检测来自至少一种金属羰基簇化合物的表面增强拉曼信号的变化，作为包含或由过氧化氢组成的一种或多种分析物的存在的指示。

公开(公告)号：US20250098963A1

公开(公告)日：2025-03-27

申请号：US18727127

申请日：2023-01-04

Applicant: Agency for Science, Technology and Research ,  National University Hospital (Singapore) Pte Ltd

Inventor： Malini OLIVO ,  Yong Geng GOH ,  Ghayathri BALASUNDARAM ,  Mohesh MOOTHANCHERY ,  Renzhe BI ,  Ruochong ZHANG

IPC: A61B5/00 ,  G06T7/00 ,  G16H30/20

Abstract: “Herein disclosed is an ex vivo method of identifying a state of a tumor margin in a sample. The method comprises operating a system to generate an ultrasound image and a photoacoustic image, wherein the system comprises: a probe configured to deliver a pulsed laser from a laser source to a sample, wherein the laser source is operable to generate the pulsed laser; arrays coupled to the probe, wherein one of the arrays comprises transducing elements arranged thereon which are operable to transmit and collect ultrasound signals, and wherein one of the arrays comprises transducing elements arranged thereon which are operable to collect photoacoustic signals; and a data acquisition module which converts the ultrasound signals and the photoacoustic signals into the ultrasound image and the photoacoustic image, respectively.”

公开(公告)号：US20210275294A1

公开(公告)日：2021-09-09

申请号：US17269179

申请日：2019-08-16

Applicant: Agency for Science, Technology and Research

Inventor： Shuyan ZHANG ,  Malini OLIVO ,  Renzhe BI

IPC: A61F2/16 ,  G02C7/02

Abstract: There is provided a lens for use in a human or animal body, the lens comprising a metasurface configured to modulate incident light, wherein the metasurface is composed of at least one light transmissive biomaterial. Also provided is a method of making the lens.