公开(公告)号：US12111248B2

公开(公告)日：2024-10-08

申请号：US16382489

申请日：2019-04-12

申请人： Labrador Diagnostics LLC

发明人： Karan Mohan ,  Chinmay Pangarkar ,  James R. Wasson

IPC分类号： G01N21/03 ,  B01L3/00 ,  B01L9/00 ,  G01N1/30 ,  G01N15/10 ,  G01N21/05 ,  G01N21/17 ,  G01N21/27 ,  G01N21/64 ,  G01N33/487 ,  G01N33/49 ,  G01N33/50 ,  G01N33/569 ,  G02B7/09 ,  G02B21/00 ,  G02B21/08 ,  G02B21/12 ,  G02B21/16 ,  G02B21/24 ,  G02B21/34 ,  G02B21/36 ,  G01N15/01 ,  G01N15/14

CPC分类号： G01N21/0303 ,  B01L3/502715 ,  B01L3/5085 ,  B01L9/523 ,  G01N1/30 ,  G01N15/1012 ,  G01N21/05 ,  G01N21/17 ,  G01N21/27 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6458 ,  G01N21/6486 ,  G01N33/487 ,  G01N33/49 ,  G01N33/5005 ,  G01N33/56966 ,  G01N33/56972 ,  G02B7/09 ,  G02B21/00 ,  G02B21/0076 ,  G02B21/088 ,  G02B21/125 ,  G02B21/16 ,  G02B21/244 ,  G02B21/34 ,  G02B21/365 ,  G02B21/367 ,  B01L2300/0654 ,  B01L2300/168 ,  G01N15/01 ,  G01N2015/1014 ,  G01N2015/1486 ,  G01N2021/1738 ,  G01N2021/6439 ,  G01N2201/061 ,  G01N2201/068 ,  G01N2201/12 ,  G01N2333/70589 ,  G01N2333/70596

摘要： Methods, devices, apparatus, and systems are provided for image analysis. Methods of image analysis may include observation, measurement, and analysis of images of biological and other samples; devices, apparatus, and systems provided herein are useful for observation, measurement, and analysis of images of such samples. The methods, devices, apparatus, and systems disclosed herein provide advantages over other methods, devices, apparatus, and systems.

公开(公告)号：US12092482B2

公开(公告)日：2024-09-17

申请号：US18362931

申请日：2023-07-31

申请人： SHANGHAI RUIYU BIOTECH CO., LTD.

发明人： Xiaojia Zhang ,  Puwen Luo ,  Yifei Wu

IPC分类号： G01C3/08 ,  G01C3/02 ,  G02B21/12 ,  G02B21/24

CPC分类号： G01C3/02 ,  G02B21/12 ,  G02B21/245

摘要： A method for laser distance measuring includes: emitting an incident ray α having an incident angle δ to a reflective surface of a laser reflecting mirror (31), the incident ray α being reflected by the laser reflecting mirror (31) to generate a first reflected ray β, and the first reflected ray β irradiating an object to be measured (1000); capturing a second reflected ray θ and generating a laser image on a laser imaging plane (3221), the second reflected ray θ being generated by the reflective surface of the laser reflecting mirror (31) reflecting a return ray γ generated after the first reflected ray β irradiates a surface of the object to be measured; and determining, based on the laser image, a measurement distance A according to a geometrical trigonometry.

公开(公告)号：US11940609B2

公开(公告)日：2024-03-26

申请号：US17084812

申请日：2020-10-30

申请人： Carl Zeiss Microscopy GmbH ,  SD Optics, Inc. ,  Stereo Display, Inc.

发明人： Alexander Gaiduk ,  Jin Young Sohn ,  Gyoungil Cho ,  Cheong Soo Seo

IPC分类号： G02B21/12 ,  G02B21/00 ,  G02B26/08

CPC分类号： G02B21/125 ,  G02B21/0032 ,  G02B26/0833

摘要： The present invention concerns an image conversion module (09) that comprises an optical interface (10) for establishing an optical path (07). The image conversion module (09) further comprises a beam splitting element (13) on the optical path (07). The beam splitting element (13) is configured for splitting a beam entering the optical interface (10, 11) on the optical path (07) into a first optical subpath (14) and a second optical subpath (16). The image conversion module (09) further comprises a microelectromechanical optical system (17) that is configured for enhancing a depth of field on the first optical subpath (14) that is directed to a first optoelectronic submodule (21). The image conversion module (09) further comprises a second optoelectronic submodule (24) having an electronic sensor (26) on the second optical subpath (16). The second optoelectronic submodule (24) is configured for acquiring additional data on the sample (02).

公开(公告)号：US20240085688A1

公开(公告)日：2024-03-14

申请号：US18514050

申请日：2023-11-20

申请人： SCOPIO LABS LTD.

发明人： Ittai MADAR ,  Eran SMALL ,  Itai HAYUT ,  Erez NA'AMAN

IPC分类号： G02B21/36 ,  G02B21/00 ,  G02B21/12

CPC分类号： G02B21/367 ,  G02B21/0084 ,  G02B21/125

摘要： A microscope comprising an illumination assembly, an image capture device and a processor can be configured to selectively identify regions of a sample comprising artifacts or empty space. By selectively identifying regions of the sample that have artifacts or empty space, the amount of time to generate an image of the sample and resources used to generate the image can be decreased substantially while providing high resolution for appropriate regions of the computational image. The processor can be configured to change the imaging process in response to regions of the sample that comprises artifacts or empty space. The imaging process may comprise a higher resolution process to output higher resolution portions of the computational image for sample regions comprising valid sample material, and a lower resolution process to output lower resolution portions of the computational image for sample regions comprising valid sample material.

公开(公告)号：US20230412905A1

公开(公告)日：2023-12-21

申请号：US18034803

申请日：2021-11-02

申请人： NORTH CAROLINA STATE UNIVERSITY

发明人： Qingshan Wei ,  Shengwei Zhang

IPC分类号： H04N23/55 ,  H04N23/51 ,  G02B21/00 ,  G02B21/36 ,  G02B21/12 ,  G02B21/16

CPC分类号： H04N23/55 ,  H04N23/51 ,  G02B21/0008 ,  G02B21/362 ,  G02B21/12 ,  G02B21/16 ,  H04M1/72409

摘要： The present invention provides methods and systems for a multimodal, portable imaging platform that can be easily installed on a mobile phone or other mobile communication devices carrying a camera. The portable imaging system includes an electronic device with a camera, a base attachment, and at least two interchangeable imaging heads. The base attachment is configured to connect to the digital device on one side and at least two removable, interchangeable imaging heads on the other side. The connected imaging head is in optical communication with the camera. Switching between different imaging modalities is as simple as switching between the interchangeable imaging heads. Each removable imaging head contains its own light source (or is optically connected to a laser diode disposed in the base attachment), lens, and/or optical filters that can be attached quickly to the same base attachment.

公开(公告)号：US20230350181A1

公开(公告)日：2023-11-02

申请号：US17731182

申请日：2022-04-27

申请人： INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

发明人： Sheng-Li CHANG ,  Chi Shen CHANG ,  Chih-Cheng HSU

IPC分类号： G02B21/12 ,  G06V20/69 ,  G02B21/34

CPC分类号： G02B21/125 ,  G06V20/69 ,  G02B21/34

摘要： A microscopic observation method configured to observe a specimen in a specimen carrier that includes the following steps: placing the specimen carrier at an observation point; obtaining a length of the specimen carrier along a movement direction, a thickness of the specimen carrier along an observation direction of a microscope objective, an observation angle of the microscope objective, and a relative distance between a lateral surface of the specimen carrier and the microscope objective along the movement direction; and adjusting an incident angle of a light beam emitted from a dark-field illumination towards the specimen carrier according to a calculation result of the length, the thickness, the observation angle, and the relative distance.

公开(公告)号：US11653826B2

公开(公告)日：2023-05-23

申请号：US16494774

申请日：2018-02-16

申请人： Sony Olympus Medical Solutions Inc.

发明人： Hiroshi Ushiroda ,  Naobumi Okada ,  Kenji Hirose

IPC分类号： A61B1/06 ,  A61B1/04 ,  A61B1/00 ,  G06T7/00 ,  G02B21/12

CPC分类号： A61B1/0655 ,  A61B1/00006 ,  A61B1/000096 ,  A61B1/00188 ,  A61B1/00193 ,  A61B1/042 ,  G06T7/0012 ,  G02B21/12

摘要： A medical observation system, a control method, and a program are provided, which are capable of easily reducing the possibility that illumination light directly enters an eye by accident. A medical observation system 1 includes: an imaging unit 21 that captures an object and generates an image signal; a light output unit 22 that outputs illumination light in a capturing direction of the imaging unit 21; a determining unit 942 that determines the usage state of the imaging unit 21; and an illumination controller 944 that controls illumination light emitted by the light output unit 22 based on a determination result of the determining unit 942.

公开(公告)号：US11356593B2

公开(公告)日：2022-06-07

申请号：US16869190

申请日：2020-05-07

申请人： University of Connecticut

发明人： Guoan Zheng

IPC分类号： H04N7/18 ,  H04N5/232 ,  G02B21/36 ,  G02B21/00 ,  G02B21/12 ,  G06T7/557 ,  G06T7/571 ,  G06T7/586 ,  G06T7/70

摘要： The present disclosure includes systems and methods for capture a whole slide image of a sample. In exemplary embodiments, a camera is configured to capture a digital image of a sample. The system captures a bright field image of the sample, and captures a digital image of the sample illuminated from a first incident angle at a first wavelength and a second incident angle at a second wavelength. The system can determine whether the sample is defocused based on the transitional shift between a first wavelength channel and a second wavelength channel of the captured digital image. The system can determine the defocus distance based on the transitional shift and autofocus using the defocus distance such the bright field image is in focus.

公开(公告)号：US11307398B2

公开(公告)日：2022-04-19

申请号：US16618773

申请日：2018-05-15

申请人： Carl Zeiss Microscopy GmbH

发明人： Daniel Haase ,  Thomas Ohrt ,  Markus Sticker

IPC分类号： G02B21/06 ,  G02B21/12 ,  G02B21/08 ,  G02B21/36

摘要： A method for generating and analyzing an overview contrast image of a specimen carrier and/or of specimens situated on a specimen carrier. A specimen carrier arranged at least partially in the focus of a detection optical unit is illuminated in transmitted light using a two-dimensional, array-like illumination pattern. At least two overview raw images are detected using different illuminations of the specimen carrier, and, according to information to be extracted from the overview contrast image, a combination algorithm is selected by means of which the at least two overview raw images are combined to form the overview contrast image. According to information to be extracted from the overview contrast image, an image evaluation algorithm is selected by means of which the information is extracted.

公开(公告)号：US20210302711A1

公开(公告)日：2021-09-30

申请号：US17218878

申请日：2021-03-31

申请人： WDI Wise Device Inc.

发明人： Alex LOPATIN

IPC分类号： G02B21/12

摘要： A system and method for generating reflective dark field illumination in an imaging system that includes a set of elementary illuminators, each of the set of elementary illuminators including a light source, a lens assembly and an illuminator aperture; and a bright field/dark field (BD) lens. The set of elementary illuminators are positioned in a ring-like shape to direct light towards a port of the BD lens. Depending on an application of the imaging system, a lens assembly focal distance and a distance between a light source and a lens assembly are determined based on the application.