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公开(公告)号：US10856799B2
公开(公告)日：2020-12-08
申请号：US16090172
申请日：2017-03-28
发明人： Hong Liang Tey , Ruchir Srivastava , Ai Ping Yow , Jun Cheng , Annan Li , Wing Kee Damon Wong , Jiang Liu , Carolin Wall
摘要： The present disclosure generally relates to an automated method and system for generating a three-dimensional (3D) representation of a skin structure of a subject. The method comprises: acquiring a plurality of two-dimensional (2D) cross-sectional images of the skin structure, specifically, using optical coherence tomography (OCT) technique; computing a cost for each 2D cross-sectional image based on a cost function, the cost function comprising an edge-based parameter and a non-edge-based parameter; constructing a 3D graph from the 2D cross-sectional images; and determining a minimum-cost closed set from the 3D graph based on the computed costs for the 2D cross-sectional images, wherein the 3D representation of the skin structure is generated from the minimum-cost closed set.
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公开(公告)号：US11116393B2
公开(公告)日：2021-09-14
申请号：US16090174
申请日：2017-03-31
发明人： Huiying Liu , Augustinus Laude , Tock Han Lim , Yanwu Xu , Wing Kee Damon Wong , Jiang Liu
摘要： The present disclosure generally relates to automated method and system for vision assessment of a subject. The method comprises: determining a set of test patterns for the subject based on a preliminary assessment of an eye of the subject; displaying the set of test patterns sequentially to the subject; collecting data on the subject's gaze in response to each test pattern displayed to the subject; and assessing vision functionality of the subject based on the collected gaze data.
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公开(公告)号：US09715640B2
公开(公告)日：2017-07-25
申请号：US14404445
申请日：2013-06-03
发明人： Yanwu Xu , Jiang Liu , Wing Kee Damon Wong , Ngan Meng Tan
CPC分类号： G06K9/6215 , G06F21/32 , G06K9/00597 , G06K9/00604 , G06K9/0061 , G06K9/00617 , G06K9/4604 , G06K9/4642 , G06K9/469 , G06K9/6892
摘要： A numerical parameter indicative of the degree of match between two retina images is produced by comparing two graphs obtained from the respective images. Each graph is composed of edges and vertices. Each vertex is associated with a location the corresponding retina image, and with descriptor data describing a part of the corresponding retina image proximate the corresponding location.
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4.发明授权公开(公告)号：US10325176B2
公开(公告)日：2019-06-18
申请号：US15506708
申请日：2015-08-25
发明人： Fengshou Yin , Wing Kee Damon Wong , Jiang Liu , Beng Hai Lee , Zhuo Zhang , Kavitha Gopalakrishnan , Ying Quan , Ai Ping Yow
摘要： A method of assessing the quality of an retinal image (such as a fundus image) includes selecting at least one region of interest within a retinal image corresponding to a particular structure of the eye (e.g. the optic disc or the macula), and a quality score is calculated in respect of the, or each, region-of-interest. Each region of interest is typically one associated with pathology, as the optic disc and the macula are. Optionally, a quality score may be calculated also in respect of the eye as a whole (i.e. over the entire image, if the entire image corresponds to the retina).
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公开(公告)号：US09679379B2
公开(公告)日：2017-06-13
申请号：US14762793
申请日：2014-01-22
发明人： Yanwu Xu , Jiang Liu , Jun Cheng , Fengshou Yin , Wing Kee Damon Wong
CPC分类号： G06T7/0014 , G06K9/46 , G06K9/52 , G06K9/6215 , G06K2009/4666 , G06T7/11 , G06T2207/30041
摘要： A method is presented to obtain, from a retinal image, data characterizing the optic cup, such as data indicating the location and/or size of the optic cup in relation to the optic disc. A disc region of the retinal image of an eye, is expressed as a weighted sum of a plurality of pre-existing “reference” retinal images in a library, with the weights being chosen to minimize a cost function. The data characterizing the cup of the eye is obtained from cup data associated with the pre-existing disc images and the corresponding weights. The cost function includes (i) a construction error term indicating a difference between the disc region of the retinal image and a weighted sum of the reference retinal images, and (ii) a cost term, which may be generated using a weighted sum over the reference retinal images of a difference between the reference retinal images and the disc region of the retinal image.
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公开(公告)号：US10145669B2
公开(公告)日：2018-12-04
申请号：US15319360
申请日：2015-06-16
发明人： Jun Cheng , Jiang Liu , Lixin Duan , Yanwu Xu , Wing Kee Damon Wong , Masahiro Akiba
摘要： A method and system are proposed to obtain a reduced speckle noise image of a subject from optical coherence tomography (OCT) image data of the subject. The cross sectional images each comprise a plurality of scan lines obtained by measuring the time delay of light reflected, in a depth direction, from optical interfaces within the subject. The method comprises two aligning steps. First the cross sectional images are aligned, then image patches of the aligned cross sectional images are aligned to form a set of aligned patches. An image matrix is then formed from the aligned patches; and matrix completion is applied to the image matrix to obtain a reduced speckle noise image of the subject.
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公开(公告)号：US09445716B2
公开(公告)日：2016-09-20
申请号：US14828262
申请日：2015-08-17
发明人： Jiang Liu , Zhuo Zhang , Wing Kee Damon Wong , Ngan Meng Tan , Fengshou Yin , Beng Hai Lee , Huiqi Li , Joo Hwee Lim , Carol Cheung , Tin Aung , Tien Yin Wong , Ziyang Liang , Jun Cheng , Baskaran Mani
CPC分类号： A61B3/0025 , A61B3/12 , A61B5/02007 , A61B5/7264 , A61B5/7267 , A61B5/7275 , G06T7/0012 , G06T7/40 , G06T2207/30041
摘要： A non-stereo fundus image is used to obtain a plurality of glaucoma indicators. Additionally, genome data for the subject is used to obtain genetic marker data relating to one or more genes and/or SNPs associated with glaucoma. The glaucoma indicators and genetic marker data are input into an adaptive model operative to generate an output indicative of a risk of glaucoma in the subject. In combination, the genetic indicators and genome data are more informative about the risk of glaucoma than either of the two in isolation. The adaptive model may be a two-stage model, having a first stage in which individual genetic indicators are combined with respective portions of the genome data by first adaptive model modules to form respective first outputs, and a second stage in which the first outputs are combined by a second adaptive mode. Texture analysis is performed on the fundus images to classify them based on their quality, and only images which are determined to meet a quality criterion are subjected to an analysis to determine if they exhibit glaucoma indicators. Also, the images are put into a standard format. The system may include estimating the position of the optic cup by combining results from multiple optic cup segmentation techniques. The system may include estimating the position of the optic disc by applying edge detection to the funds image, excluding edge points that are unlikely to be optic disc boundary points, and estimating the position of an optic disc by fitting an ellipse to the remaining edge points.
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公开(公告)号：US20150186752A1
公开(公告)日：2015-07-02
申请号：US14404445
申请日：2013-06-03
发明人： Yanwu Xu , Jiang Liu , Wing Kee Damon Wong , Ngan Meng Tan
CPC分类号： G06K9/6215 , G06F21/32 , G06K9/00597 , G06K9/00604 , G06K9/0061 , G06K9/00617 , G06K9/4604 , G06K9/4642 , G06K9/469 , G06K9/6892
摘要： A numerical parameter indicative of the degree of match between two retina images is produced by comparing two graphs obtained from the respective images. Each graph is composed of edges and vertices. Each vertex is associated with a location the corresponding retina image, and with descriptor data describing a part of the corresponding retina image proximate the corresponding location.
摘要翻译： 通过比较从各图像获得的两个图来产生表示两个视网膜图像之间的匹配程度的数值参数。 每个图形由边和顶点组成。 每个顶点与对应的视网膜图像的位置相关联，并且描述符数据描述在对应位置附近的对应的视网膜图像的一部分。
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9.发明申请METHODS AND SYSTEMS FOR CHARACTERIZING ANGLE CLOSURE GLAUCOMA FOR RISK ASSESSMENT OR SCREENING 有权用于表征风险评估或筛选的角膜闭合玻璃体的方法和系统公开(公告)号：US20150161785A1
公开(公告)日：2015-06-11
申请号：US14419237
申请日：2013-08-01
发明人： Yanwu Xu , Jiang Liu , Wing Kee Damon Wong , Beng Hai Lee , Tin Aung , Baskaran Mani , Shamira Perera
CPC分类号： G06T7/0012 , A61B3/102 , A61B3/117 , G06K9/46 , G06K2009/4666 , G06T7/73 , G06T2207/10072 , G06T2207/10101 , G06T2207/30041
摘要： A method is proposed for analysing an optical coherence tomography (OCT) image of the anterior segment (AS) of a subject's eye. A region of interest is defined which is a region of the image containing the junction of the cornea and iris, and an estimated position the junction within the region of interest is derived. Using this a second region of the image is obtained, which is a part of the image containing the estimated position of the junction. Features of the second region are obtained, and those features are input to an adaptive model to generate data characterizing the junction.
摘要翻译： 提出了一种用于分析受试者眼睛前段（AS）的光学相干断层扫描（OCT）图像的方法。 定义感兴趣区域，其是包含角膜和虹膜的交界处的图像的区域，以及估计的位置，导出感兴趣区域内的结。 使用该图像获得图像的第二区域，其是包含结点的估计位置的图像的一部分。 获得第二区域的特征，并且将这些特征输入到自适应模型以生成表征结点的数据。
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公开(公告)号：US10478058B2
公开(公告)日：2019-11-19
申请号：US15528080
申请日：2015-11-19
发明人： Jun Cheng , Jiang Liu , Wing Kee Damon Wong , Masahiro Akiba
摘要： An optical coherence tomography (OCT) image composed of a plurality of A-scans of a structure is analyzed by defining, for each A-scan, a set of neighboring A-scans surrounding the A-slices scan. Following an optional de-noising step, the neighboring A-scans are aligned in the imaging direction, then a matrix X is formed from the aligned A-scans, and matrix completion is performed to obtain a reduced speckle noise image.
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