公开(公告)号：US20220177848A1

公开(公告)日：2022-06-09

申请号：US17680619

申请日：2022-02-25

Applicant: AJINOMOTO CO., INC.

Inventor： Ikue HARATA ,  Eri HARADA ,  Kazuma TAKAHASHI ,  Fumie HONKAWA

IPC: C12N5/0775 ,  C12N5/00

Abstract: Mesenchymal stem cells may be efficiently obtained from a biological cell sample containing mesenchymal stem cells by: (1) culturing the biological cell sample containing mesenchymal stem cells in a serum-free medium in the presence of vitronectin or a partial peptide thereof capable of adhering mesenchymal stem cells, and (2) collecting a cell aggregate of the mesenchymal stem cells.

公开(公告)号：US20220073873A1

公开(公告)日：2022-03-10

申请号：US17454692

申请日：2021-11-12

Applicant: AJINOMOTO CO., INC.

Inventor： Shizuka BABA ,  Kazuma TAKAHASHI ,  Atsushi KONISHI

IPC: C12N5/079

Abstract: Neural crest cells or corneal epithelial cells may be purified by expansion culturing in the presence of laminin as a scaffold.

公开(公告)号：US20240182862A1

公开(公告)日：2024-06-06

申请号：US18533804

申请日：2023-12-08

Applicant: AJINOMOTO CO., INC.

Inventor： Kazuma TAKAHASHI ,  Shizuka BABA ,  Atsushi KONISHI

IPC: C12N5/0775 ,  A61K35/28 ,  A61P1/16 ,  C07K14/47

CPC classification number: C12N5/0668 ,  A61K35/28 ,  A61P1/16 ,  C07K14/4718 ,  C12N2500/90 ,  C12N2501/39 ,  C12N2506/08 ,  C12N2506/45 ,  C12N2533/52

Abstract: A medicament for the prophylaxis or treatment of inflammatory diseases or fibrous diseases, may be produced by inducing mesenchymal stem cells by culturing neural crest cells in a medium composition for inducing mesenchymal stem cells from neural crest cells, comprising a basal medium and corticosteroid, the composition having a converted concentration of the corticosteroid in the medium composition of not less than 1.25 μM.