公开(公告)号：US20150011003A1

公开(公告)日：2015-01-08

申请号：US14497926

申请日：2014-09-26

Applicant: AJINOMOTO CO., INC.

Inventor： Yoko KURIYAMA ,  Nao SUGIMOTO ,  Manabu KITAZAWA ,  Satoru OKAMOTO ,  Sho SENDA ,  Ikue HARATA ,  Satoru OHASHI

IPC: C12N5/0775 ,  C08G63/91 ,  C08G65/48 ,  C12N5/074

CPC classification number: C12N5/0663 ,  C08G63/912 ,  C08G65/48 ,  C12N5/0696 ,  C12N2500/34 ,  C12N2501/115

Abstract: A medium which comprises a fibroblast growth factor (FGF), and a sulfated compound or a pharmaceutically acceptable salt thereof at a concentration which promotes the growth of a stem cell in the presence of FGF, is useful for culturing stem cells.

Abstract translation: 包含成纤维细胞生长因子（FGF）的培养基和在FGF存在下促进干细胞生长的浓度的硫酸化合物或其药学上可接受的盐可用于培养干细胞。

公开(公告)号：US20190024047A1

公开(公告)日：2019-01-24

申请号：US16144187

申请日：2018-09-27

Applicant: AJINOMOTO CO., INC.

Inventor： Takuya MATSUMOTO ,  Ikue HARATA ,  Sho SENDA

IPC: C12N5/0793 ,  C12N5/0797

Abstract: Media which are substantially free of one or more amino acids selected from the group consisting of L-glutamine, L-asparagine, and L-aspartic acid are useful for producing a neural stem cell and/or a neural progenitor cell with promoted neuronal differentiation potency.

公开(公告)号：US20220177848A1

公开(公告)日：2022-06-09

申请号：US17680619

申请日：2022-02-25

Applicant: AJINOMOTO CO., INC.

Inventor： Ikue HARATA ,  Eri HARADA ,  Kazuma TAKAHASHI ,  Fumie HONKAWA

IPC: C12N5/0775 ,  C12N5/00

Abstract: Mesenchymal stem cells may be efficiently obtained from a biological cell sample containing mesenchymal stem cells by: (1) culturing the biological cell sample containing mesenchymal stem cells in a serum-free medium in the presence of vitronectin or a partial peptide thereof capable of adhering mesenchymal stem cells, and (2) collecting a cell aggregate of the mesenchymal stem cells.

公开(公告)号：US20190136202A1

公开(公告)日：2019-05-09

申请号：US16242463

申请日：2019-01-08

Applicant: AJINOMOTO CO., INC.,

Inventor： Sho SENDA ,  Tomomi YOSHIDA ,  Satoru OKAMOTO ,  Yoko KURIYAMA ,  Manabu KITAZAWA ,  Ikue HARATA ,  Nao SUGIMOTO

IPC: C12N5/074 ,  C12N5/0735 ,  C12N5/00

CPC classification number: C12N5/0696 ,  C12N5/0043 ,  C12N5/0606 ,  C12N2500/36 ,  C12N2500/46 ,  C12N2500/84 ,  C12N2533/90

Abstract: Cultivating a pluripotent stem cell in a medium comprising at least one member selected from the group consisting of ethanolamine, an ethanolamine analog, and a s pharmaceutically acceptable salt thereof, and which is substantially free of β-mercaptoethanol or contains β-mercaptoethanol at a concentration of not more than 9 μM, and the like, is effective for the proliferation of a pluripotent stem cell while maintaining an undifferentiated state.