公开(公告)号：US20250026799A1

公开(公告)日：2025-01-23

申请号：US18914383

申请日：2024-10-14

Applicant: AJINOMOTO CO., INC.

Inventor： Naoko TSUYOSHI ,  Teruhisa MANNEN ,  Yoshihiko MATSUDA ,  Shimpei OGAWA ,  Yasumichi KOSEKI ,  Tomomi KADO

IPC: C07K14/50 ,  C12N5/077

Abstract: A method of producing cultured meat is provided. Cultured meat is produced by culturing animal cells in the presence of bovine basic fibroblast growth factor (bbFGF) produced by using a coryneform bacterium as an expression host.

公开(公告)号：US20250101129A1

公开(公告)日：2025-03-27

申请号：US18966063

申请日：2024-12-02

Applicant: Ajinomoto Co., Inc.

Inventor： Yutaka MATSUDA ,  Tomohiro FUJII ,  Kenichiro ITO ,  Kazutoshi TAKAHASHI ,  Yoshihiko MATSUDA ,  Hiroki YAMAGUCHI ,  Naoko TSUYOSHI ,  Hayato NAGANO ,  Rika TAKASUGI

IPC: C07K16/32 ,  C07K16/28

Abstract: The present invention relates to a technology for easy chemical modification of only one heavy chain in the constituent unit of an antibody (immunoglobulin unit containing two heavy chains and optionally two light chains). More particularly, the present invention relates to a compound or a salt thereof, containing (A) an affinity substance containing first and second affinity moieties each having an affinity to the constant region in a heavy chain of an antibody; and (B) a reactive group for the antibody.

公开(公告)号：US20240277783A1

公开(公告)日：2024-08-22

申请号：US18631361

申请日：2024-04-10

Applicant: Ajinomoto Co., Inc.

Inventor： Riku USAMI ,  Miku TOYAZAKI ,  Hidehiro NAKAMURA ,  Yoshihiko MATSUDA

IPC: A61K35/744 ,  A61K35/747 ,  C07K14/50 ,  C12N15/74

CPC classification number: A61K35/744 ,  A61K35/747 ,  C07K14/503 ,  C12N15/746 ,  C07K2319/10

Abstract: Provided herein is a technology whereby a heterologous protein can be expressed in a bacterium which does not have an endogenous Tat system secretion machine. The present specification discloses a bacterium such as bifidobacteria, lactococci, and staphylococci which has been modified to express a heterologous Tat protein. The bacterium has the ability to produce and secrete a heterologous protein.

公开(公告)号：US20210300972A1

公开(公告)日：2021-09-30

申请号：US17241585

申请日：2021-04-27

Applicant: Ajinomoto Co., Inc.

Inventor： Kei YAMADA ,  Yoshihiko MATSUDA ,  Kazutoshi TAKAHASHI ,  Natsuki SHIKIDA ,  Kazutaka SHIMBO ,  Hayato NAGANO

IPC: C07K14/31 ,  C07K16/32

Abstract: Compounds having an affinity substance to an antibody, a cleavable portion, and a reactive group, or a salt thereof, are represented by the following Formula (I): A-L-B—R  (I) wherein A is an affinity substance to an antibody, L is a cleavable linker that is a divalent group comprising a cleavable portion, B is (a) a divalent group comprising a bioorthogonal functional group or (b) a divalent group comprising no bioorthogonal functional group, and R is a reactive group to the antibody, wherein the affinity substance to an antibody is a polypeptide comprising a glutamine residue (Q) at an N-terminal.