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公开(公告)号：US20210139549A1
公开(公告)日：2021-05-13
申请号：US17119786
申请日：2020-12-11
Applicant: AJINOMOTO CO., INC.
Inventor： Kei YAMADA , Tomohiro FUJII , Natsuki SHIKIDA , Kazutaka SHIMBO
Abstract: Compounds having an affinity substance to an antibody, a cleavable portion, and a reactive group, represented by the following Formula (I): A-L-B-R (I) wherein A is the affinity substance an antibody, L is a cleavable linker which is a divalent group comprising the cleavable portion, B is (a) a divalent group comprising a bioorthogonal functional group or (b) a divalent group comprising no bioorthogonal functional group, and R is the reactive group to the antibody, in which the affinity substance to an antibody is a certain peptide, or a salt thereof are useful for the modification of an antibody, particularly the regioselective modification of an antibody.
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公开(公告)号：US20240058473A1
公开(公告)日：2024-02-22
申请号：US18467134
申请日：2023-09-14
Applicant: Ajinomoto Co., Inc.
Inventor： Kei YAMADA , Yutaka MATSUDA , Ippei INOUE , Natsuki SHIKIDA , Kazutaka SHIMBO
CPC classification number: A61K47/6949 , A61K47/6835 , A61K47/6889
Abstract: The present invention provides a highly controlled complex comprising an antibody and ferritin particles. More specifically, the present invention provides the inventions of a complex or salt thereof comprising (A) one IgG antibody and (B) two human ferritin particles comprising one or more human ferritin H chains linked thereto; and methods for producing the same.
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公开(公告)号：US20190228844A1
公开(公告)日：2019-07-25
申请号：US16373427
申请日：2019-04-02
Applicant: AJINOMOTO CO., INC.
Inventor： Hidehiro NAKAMURA , Natsumi NISHIKATA , Akira IMAIZUMI , Kazutaka SHIMBO , Naoko ARASHIDA , Rumi NISHIMOTO
IPC: G16C20/70
Abstract: An evaluating method includes an evaluating step of evaluating a state of colorectal cancer for a subject to be evaluated using (i) a concentration value of at least one metabolite of bABA, N-Me-bABA, 1-Me-His, aABA, Aminoadipic acid, bAiBA, Cadaverine, Ethylglycine, GABA, Homoarginine, Hypotaurine, Kinurenine, N6-Acetyl-L-Lys, Putrescine, Serotonin, Spermidine, Spermine, ADMA, Homocitrulline, 3-Me-His, Hydroxyproline, Phosphoethanolamine, SDMA, Acylcarnitine (13:1), and EPA in blood of the subject or (ii) a value of a formula calculated using the concentration value of the metabolite and the formula including an explanatory variable to be substituted with the concentration value of the metabolite.
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公开(公告)号：US20250020656A1
公开(公告)日：2025-01-16
申请号：US18784141
申请日：2024-07-25
Applicant: AJINOMOTO CO., INC.
Inventor： Naoko ARASHIDA , Rumi NISHIMOTO , Kazutaka SHIMBO , Hidehiro NAKAMURA , Natsumi NISHIKATA , Akira IMAIZUMI
IPC: G01N33/68 , G01N33/574 , G16H50/20
Abstract: An evaluating method includes an evaluating step of evaluating a state of lung cancer for a subject to be evaluated using a concentration value of at least one of Homoarginine, GABA, 3-Me-His, ADMA, Spermine, Spermidine, Cystathionine, Sarcosine, aAiBA, bAiBA, Putrescine, N-Acetyl-L-lys, Hypotaurine, bABA, and Ethylglycine in blood of the subject.
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公开(公告)号：US20240366783A1
公开(公告)日：2024-11-07
申请号：US18666145
申请日：2024-05-16
Applicant: AJINOMOTO CO., INC.
Inventor： Kei YAMADA , Yutaka MATSUDA , Tomohiro FUJII , Natsuki SHIKIDA , Reiko YUJI , Kazutaka SHIMBO , Yuji ITO
Abstract: The present invention provides a technique enabling modification of a soluble protein and in particular regioselective modification of a soluble protein. More specifically, the present invention provides a compound having an affinity substance to a soluble protein, a cleavable portion, and a reactive group represented by the following Formula (I): A-L-B-R (I) wherein A is an affinity substance to a soluble protein; L is a cleavable linker which is a divalent group comprising a cleavable portion; B is (a) a divalent group comprising a bioorthogonal functional group or (b) a divalent group comprising no bioorthogonal functional group; and R is a reactive group to the soluble protein; or a salt thereof.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20180017570A1
公开(公告)日：2018-01-18
申请号：US15715389
申请日：2017-09-26
Applicant: AJINOMOTO CO., INC.
Inventor： Naoko ARASHIDA , Rumi NISHIMOTO , Kazutaka SHIMBO , Hidehiro NAKAMURA , Natsumi NISHIKATA , Akira IMAIZUMI
IPC: G01N33/68 , G01N33/574 , G06F19/00
CPC classification number: G01N33/6812 , G01N33/57423 , G01N2800/56 , G06F19/3418 , G16H50/20
Abstract: An evaluating method includes an evaluating step of evaluating a state of lung cancer for a subject to be evaluated using a concentration value of at least one of Homoarginine, GABA, 3-Me-His, ADMA, Spermine, Spermidine, Cystathionine, Sarcosine, aAiBA, bAiBA, Putrescine, N-Acetyl-L-lys, Hypotaurine, bABA, and Ethylglycine in blood of the subject.
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公开(公告)号：US20170044513A1
公开(公告)日：2017-02-16
申请号：US15252664
申请日：2016-08-31
Applicant: AJINOMOTO CO., INC.
Inventor： Noriko YOKOYAMA , Mayu NAKANO , Shuhei HASHIRO , Masako HIRAGA , Kazutaka SHIMBO , Ayaka TOKUNAGA
Abstract: A novel protein deamidase having an activity of directly acting on a side chain amide group of an asparagine residue in a protein to form a side chain carboxyl group and release ammonia, a microorganism that produces the same, a gene encoding the same, a method for producing the same, and use of the same are provided. A bacterium classified into the class Actinobacteria is cultured to generate protein deamidase, and the enzyme is collected from culture.
Abstract translation: 一种新型蛋白质脱酰胺酶，其具有直接作用于蛋白质中的天冬酰胺残基的侧链酰胺基的活性，形成侧链羧基并释放氨，产生该氨基酸的微生物，编码该氨基酸的基因， 生产它们，并提供其使用。 培养分类为放线杆菌的细菌以产生蛋白质脱酰胺酶，并从培养物中收集酶。
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公开(公告)号：US20230279063A1
公开(公告)日：2023-09-07
申请号：US18062906
申请日：2022-12-07
Applicant: Ajinomoto Co., Inc.
Inventor： Kei YAMADA , Ippei INOUE , Natsuki SHIKIDA , Kazutaka SHIMBO
Abstract: Controlling the number of modifying groups introduced into a surface of ferritin affords a modified ferritin containing a human ferritin H chain, in which the human ferritin H chain contains a modifying group that is covalently bonded specifically to a cysteine residue at position 91 and/or position 103 according to a reference position of a natural human ferritin H chain.
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公开(公告)号：US20210300972A1
公开(公告)日：2021-09-30
申请号：US17241585
申请日：2021-04-27
Applicant: Ajinomoto Co., Inc.
Inventor： Kei YAMADA , Yoshihiko MATSUDA , Kazutoshi TAKAHASHI , Natsuki SHIKIDA , Kazutaka SHIMBO , Hayato NAGANO
Abstract: Compounds having an affinity substance to an antibody, a cleavable portion, and a reactive group, or a salt thereof, are represented by the following Formula (I): A-L-B—R (I) wherein A is an affinity substance to an antibody, L is a cleavable linker that is a divalent group comprising a cleavable portion, B is (a) a divalent group comprising a bioorthogonal functional group or (b) a divalent group comprising no bioorthogonal functional group, and R is a reactive group to the antibody, wherein the affinity substance to an antibody is a polypeptide comprising a glutamine residue (Q) at an N-terminal.
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10.发明申请公开(公告)号：US20210139541A1
公开(公告)日：2021-05-13
申请号：US17119495
申请日：2020-12-11
Applicant: Ajinomoto Co., Inc.
Inventor： Yutaka MATSUDA , Noriko HATADA , Kei YAMADA , Natsuki SHIKIDA , Kazutaka SHIMBO , Tomohiro FUJII , Shigeo HIRASAWA
Abstract: Compounds having an affinity substance to an antibody and a bioorthogonal functional group, represented by the following Formula (I): A-L-E-B (I) wherein A is an affinity substance to an antibody, L is a divalent group comprising a leaving group, E is a divalent group comprising an electrophilic group (i) coupled with the leaving group and (ii) having ability to react with a nucleophilic group in the antibody, B is a bioorthogonal functional group, and the leaving group has ability to be cleaved and eliminated from E by a reaction between the nucleophilic group and the electrophilic group, or a salt thereof, and the like are useful for labelling antibodies.
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