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公开(公告)号：US3625825A
公开(公告)日：1971-12-07
申请号：US3625825D
申请日：1969-01-03
申请人： AJINOMOTO KK
发明人： SHIBAI HIROSHI , YAMANOI AKIO , SHIRO TERUO , HAMA AKIRA , KINOSHITA KAZUMOTO
CPC分类号： C12P19/40 , Y10S435/839
摘要： All strains of Bacillus subtilis which produce inosine or guanosine by fermentation give higher yields of these nucleosides when the culture medium contains potassium, magnesium, or calcium ions in much higher concentrations than were commonly employed heretofore.
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公开(公告)号：US3586604A
公开(公告)日：1971-06-22
申请号：US3586604D
申请日：1968-06-07
申请人： AJINOMOTO KK
发明人： YAMANOI AKIO , SHIRO TERUO
摘要： INOSINE, GUANOSINE, XANTHOSINE, ADENOSINE, AND 5-AMINO4-IMIDAZOLECARBOXAMIDE RIBOSIDE CAN BE PHOSPHORYLATED TO THE CORRESPONDING 5''-NUCLEOTIDES BY MEANS OF STRAINS OF CORYNEBACTERIUM IN OTHERWISE CONVENTIONAL AQUEOUS CULTURE MEDIA CONTAINING INORGANIC PHOSPHATES.
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3.发明授权Method of converting heterocyclic bases into the corresponding nucleosides by bacterial action 失效通过细菌作用将杂环基转化为相应的核苷酸的方法
公开(公告)号：US3535207A
公开(公告)日：1970-10-20
申请号：US3535207D
申请日：1969-08-19
申请人： AJINOMOTO KK
发明人： SHIRO TERUO , HIROSE YOSHITERU , KAMIMURA AKIRA , YAMANOI AKIO , MITSUGI KOJI
CPC分类号： C12P19/28 , C12P19/40 , Y10S435/839
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公开(公告)号：US3674639A
公开(公告)日：1972-07-04
申请号：US3674639D
申请日：1970-05-18
申请人： AJINOMOTO KK , SANRAKU OCEAN CO
发明人： IKEDA SHIGEHO , ISHIZAKI AYAAKI , HIROSE YOSHIO , SHIRO TERUO
CPC分类号： C12P13/14 , Y10S435/83 , Y10S435/84 , Y10S435/843
摘要： ARTIFICIALLY INDUCED MUTANTS OF THE GLUTAMIC ACID PRODUCING MICROORGANISMS BREVIBACTERIUM KETOGLUTAMICUM, CORYNEBACTERIUM HYDROCARBOCLASTUS, AND ARTHROBACTER PARAFFINEUS WHICH ARE CAPABLE OF GROWING ON AN AGAR MEDIUM CONTAINING SUBSTANCES HAVING PENICILLIN ACTIVITY IN AN AMOUNT CORRESPONDING TO MORE THAN 5 INTERNATIONAL OR U.S.P. PENICILLIN UNITS PER MILLILITER HAVE BEEN FOUND CAPABLE OF ASSIMILATING HYDROCARBONS AND THEIR OXIDATION PRODUCTS AS THE PRINCIPAL SOURCE OF CARBON FROM A NUTRIENT MEDIUM CONTAINING PENICILLIN-ACTIVE SUBSTANCES IN HIGH CONCENTRATIONS, AND TO CONVERT THE ADDIMILATED MATERIAL TO L-GLUTAMIC ACID RELATIVELY RAPIDLY UNTIL CONCENTRATIONS OF MORE THAN 7 G./DL. ARE REACHED IN THE MEDIUM.
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公开(公告)号：US3661711A
公开(公告)日：1972-05-09
申请号：US3661711D
申请日：1968-12-23
申请人： AJINOMOTO KK
发明人： KUBOTA KOJI , SHIRO TERUO
IPC分类号： C07D233/54 , C07D233/64 , C12P17/10 , C12B1/00
CPC分类号： C07D233/64 , C12P17/10 , Y10S435/83 , Y10S435/84 , Y10S435/843
摘要： Histidinol is accumulated in histidine-containing, but otherwise conventional aqueous culture media on which histidine-requiring mutants of Brevibacterium, Corynebacterium, or Arthrobacter are cultured, and is readily recovered from the fermentation broth.
摘要翻译： 组氨酸含有，但是在其中培养短杆菌属，棒杆菌属或节节杆菌组氨酸需要突变体的常规水性培养基中积累，并且容易从发酵液中回收。
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6.发明授权Method of producing 5-amino-4-imid-azolecarboxamide ribofuranoside by fermentation 失效通过发酵生产5-氨基-4-咪唑并吡咯并呋喃甲酰胺的方法
公开(公告)号：US3582470A
公开(公告)日：1971-06-01
申请号：US3582470D
申请日：1969-07-10
申请人： AJINOMOTO KK
发明人： TSURI HARUO , TAKINAMI KOICHI , SHIRO TERUO , OKADA HIROSHI
CPC分类号： C07H19/04 , C12P19/30 , Y10S435/837 , Y10S435/839
摘要： THE YIELD OF AICAR BY FERMENTATION OF OTHERWISE CONVENTIONAL CULTURE MEDIA BY MEANS OF CERTAIN STRAINS OF BACILLUS SURBTILIS AND BACILLUS MEGATERIUM IS SHARPLY INCREASED WHEN THE MEDIA ARE NEUTRALIZED BY MEANS OF GASEOUS AMMONIA AND CONTAIN MORE THAN 10 MG./DL. MAGNESIUM IONS.
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公开(公告)号：US3623952A
公开(公告)日：1971-11-30
申请号：US3623952D
申请日：1968-11-20
申请人： AJINOMOTO KK
发明人： KUBOTA KOJI , SHIRO TERUO
CPC分类号： C12P13/06 , Y10S435/83 , Y10S435/84 , Y10S435/843 , Y10S435/921
摘要： When certain strains of Brevibacterium helvolum, Arthrobacter citreus, Corynebacterium sp., and Candida pulcherrima are cultured aerobically at pH 5-9 on an otherwise conventional aqueous medium containing 0.5 percent to 4 percent by weight glycine, L-serine accumulates in the culture broth and is readily recovered in high yields.
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公开(公告)号：US3616215A
公开(公告)日：1971-10-26
申请号：US3616215D
申请日：1969-11-04
申请人： AJINOMOTO KK
发明人： SASAKI HIROSHI , KAMIMURA AKIRA , YAMADA KAZUHIKO , SHIRO TERUO , OKUMURA SHINJI
CPC分类号： C12P19/32 , Y10S435/83
摘要： Substantial amounts of 5'' inosinic acid are formed from adenine when a conventional culture medium containing a source of phosphate ions and adenine is fermented by means of the newly discovered species Arthrobacter nucleogenes.
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公开(公告)号：US3527672A
公开(公告)日：1970-09-08
申请号：US3527672D
申请日：1969-10-28
申请人： AJINOMOTO KK
发明人： KUBOTA KOJI , MAEYASHIKI ISAMU , SHIRO TERUO , NOBORU KATSUYA
CPC分类号： C12P13/08 , Y10S435/84
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公开(公告)号：US3704205A
公开(公告)日：1972-11-28
申请号：US3704205D
申请日：1970-03-02
申请人： AJINOMOTO KK
发明人： SHIRO TERUO , TAKINAMI KOICHI , AKUTSU EIICHI , YOSHII HIROE , YAMADA YASUTSUGU
CPC分类号： C12P13/14 , Y10S435/84 , Y10S435/843 , Y10S435/859
摘要： THE YIELD OF L-GLUTAMIC ACID FROM AEROBIC CULTURES OF BACTERIA CAN BE INCREASED MATERIALLY BY SMALL AMOUNTS OF ANTIOXIDANTS IN THE NUTRIENT MEDIUM. ANTI-FOAMING AGENTS NOT OTHERWISE COMPATIBLE WITH GLUTAMIC ACID CULTURES MAY BE EMPLOYED IN THE PRESENCE OF THE ANTIOXIDANTS.
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