公开(公告)号：US3164531A

公开(公告)日：1965-01-05

申请号：US23027562

申请日：1962-10-12

申请人： AJINOMOTO KK ,  SANRAKU OCEAN CO INC

发明人： HIROSHI OKADA ,  KOICHI TAKINAMI ,  HARUO TSURI ,  ISAMU SHIIO ,  TOSHINAO TSUNODA

IPC分类号： C12P13/14 ,  C12P13/16

CPC分类号： C12P13/14 ,  C12P13/16 ,  Y10S435/84

公开(公告)号：US3563857A

公开(公告)日：1971-02-16

申请号：US3563857D

申请日：1968-03-15

申请人： SANRAKU OCEAN CO ,  AJINOMOTO KK

发明人： OKI TOSHIKAZU ,  NISHIMURA YUKIO ,  SAYAMA YOSHIO ,  TAKEMI HISAO ,  KITAI ATSUO ,  OZAKI ASAICHIRO

IPC分类号： C12P13/14 ,  C12B3/00

CPC分类号： C12P13/14 ,  Y10S435/828 ,  Y10S435/829 ,  Y10S435/83 ,  Y10S435/84 ,  Y10S435/859 ,  Y10S435/866 ,  Y10S435/874 ,  Y10S435/923 ,  Y10S435/942 ,  Y10S435/944

摘要： MANY YEASTS AND BACTERIA ARE CAPABLE OF GROWTH ON OTHERWISE CONVENTIONAL CULTURE MEDIA WHICH CONTAIN ETHANOL AS THE PRINCIPAL SOURCE OF CARBON, AND PRODUCE L-GLUTAMIC ACID WHICH MAY BE RECOVERED IN COMMERCIALLY USEFUL AMOUNTS. THE MEDIUM SHOULD CONTAIN NO MORE THAN 10% ETHANOL FOR GOOD YIELDS, AND THE ETHANOL CONTENT MAY BE REPLENISHED BY MIXING THE ETHANOL WITH THE AERATION GAS.

公开(公告)号：US3533914A

公开(公告)日：1970-10-13

申请号：US3533914D

申请日：1967-11-21

申请人： AJINOMOTO KK ,  SANRAKU OCEAN CO

发明人： OKUMURA SHINJI ,  TSUGAWA RYUICHIRO ,  KURONUMA HIDEO

IPC分类号： C12P13/14 ,  C12B1/00 ,  C12D3/00

CPC分类号： C12P13/14 ,  Y10S435/813 ,  Y10S435/83 ,  Y10S435/84 ,  Y10S435/843 ,  Y10S435/859

公开(公告)号：US3743582A

公开(公告)日：1973-07-03

申请号：US3743582D

申请日：1970-05-27

申请人： SANRAKU OCEAN CO

发明人： KITAI A ,  TONE H ,  OZAKI A

IPC分类号： C12M1/04 ,  C12M1/06 ,  C12B1/00 ,  C12B1/10 ,  C12B1/14

CPC分类号： C12M23/34 ,  C12M27/22 ,  Y10S435/813

摘要： A METHOD OF FERMENTATION UTILIZING A MULTI-STAGE FERMENTING DEVICE, WHICH COMPRISES THE STEP OF CULTURING MICRO-ORGANISMS AEROBICALLY OR ANAEROBICALLY, IN A DEVICE COMPRISING A VERTICAL STACK OF COMPARTMENTS SEPARATED BY HORIZONTAL PLATES PROVIDED WITH ONE OR MORE HOLES BY INTRODUCING GAS AND CULTURE MEDIUM FROM THE BOTTOM AND

MAINTAINING A LAYER OF GAS BENEATH EACH PLATE WHICH PREVENTS BACKFLOW OF MEDIUM FROM ANY COMPARTMENT TO ONE THEREBELOW.

公开(公告)号：US3674639A

公开(公告)日：1972-07-04

申请号：US3674639D

申请日：1970-05-18

申请人： AJINOMOTO KK ,  SANRAKU OCEAN CO

发明人： IKEDA SHIGEHO ,  ISHIZAKI AYAAKI ,  HIROSE YOSHIO ,  SHIRO TERUO

IPC分类号： C12P13/14 ,  C12D1/00

CPC分类号： C12P13/14 ,  Y10S435/83 ,  Y10S435/84 ,  Y10S435/843

摘要： ARTIFICIALLY INDUCED MUTANTS OF THE GLUTAMIC ACID PRODUCING MICROORGANISMS BREVIBACTERIUM KETOGLUTAMICUM, CORYNEBACTERIUM HYDROCARBOCLASTUS, AND ARTHROBACTER PARAFFINEUS WHICH ARE CAPABLE OF GROWING ON AN AGAR MEDIUM CONTAINING SUBSTANCES HAVING PENICILLIN ACTIVITY IN AN AMOUNT CORRESPONDING TO MORE THAN 5 INTERNATIONAL OR U.S.P. PENICILLIN UNITS PER MILLILITER HAVE BEEN FOUND CAPABLE OF ASSIMILATING HYDROCARBONS AND THEIR OXIDATION PRODUCTS AS THE PRINCIPAL SOURCE OF CARBON FROM A NUTRIENT MEDIUM CONTAINING PENICILLIN-ACTIVE SUBSTANCES IN HIGH CONCENTRATIONS, AND TO CONVERT THE ADDIMILATED MATERIAL TO L-GLUTAMIC ACID RELATIVELY RAPIDLY UNTIL CONCENTRATIONS OF MORE THAN 7 G./DL. ARE REACHED IN THE MEDIUM.

公开(公告)号：US3551292A

公开(公告)日：1970-12-29

申请号：US3551292D

申请日：1968-02-20

申请人： AJINOMOTO KK ,  SANRAKU OCEAN CO

发明人： KAMIMURA AKIRA ,  TSUGAWA RYUICHIRO ,  OKUMURA SHINJI

IPC分类号： C12P13/14 ,  C12B1/00

CPC分类号： C12P13/14 ,  Y10S435/84 ,  Y10S435/843 ,  Y10S435/861

公开(公告)号：US3784446A

公开(公告)日：1974-01-08

申请号：US3784446D

申请日：1972-03-08

申请人： AJINOMOTO KK ,  SANRAKU OCEAN CO

发明人： NISHIDA H ,  YAMAMOTO M ,  NISHIMURA Y ,  TAKEMI H ,  KITAI A ,  OZAKI A ,  TAKEMI C

IPC分类号： C12P13/14 ,  C12D13/06

CPC分类号： C12P13/14 ,  Y10S435/822 ,  Y10S435/84 ,  Y10S435/843 ,  Y10S435/861

摘要： L-Glutamic acid is produced by culturing glutamic acid producing strains of Brevibacterium, Corynebacterium, Microbacterium, and Micrococcus on media which provide catechol, benzyl alcohol, benzoic acid, hydroxybenzoic acid, phenylacetic acid, protocatechuic acid, phenol and other aromatic compounds as at least 70 percent (by weight) of the carbon sources available during fermentation.

摘要翻译： 在提供儿茶酚，苄醇，苯甲酸，羟基苯甲酸，苯乙酸，原儿茶酸，苯酚等芳香族化合物的培养基上培养产生短杆菌，棒状杆菌，微杆菌，微球菌的谷氨酸生产菌株至少产生L-谷氨酸 70％（重量）的发酵过程中可用的碳源。

公开(公告)号：US3622458A

公开(公告)日：1971-11-23

申请号：US3622458D

申请日：1969-09-29

申请人： SANRAKU OCEAN CO

发明人： MURAO SAWAO

IPC分类号： C12N9/56 ,  C07G7/028

CPC分类号： C12N9/54 ,  Y10S435/816 ,  Y10S435/839

摘要： A new, peptide-forming type of alkaline protease which is characteristically different from any similar commercial product in substrate specificity, decomposition pattern, amino acid composition, elementary analysis and other physicochemical properties, and which has the greatest enzymatic activity between pH 11.0 and 11.7. The invention includes a method of preparing said enzyme by cultivating Bacillus subtilis var sakainensis (ATCC 21394), and by purifying the crude enzyme preparation obtained therefrom at a larger yield in comparison with other commercially available proteases, in crystal form, by a very simplified method.

公开(公告)号：US3663370A

公开(公告)日：1972-05-16

申请号：US3663370D

申请日：1969-03-26

申请人： AJINOMOTO KK ,  SANRAKU OCEAN CO

发明人： KONO KAGEAKI ,  OKI TOSHIKAZU ,  KITAI ATSUO ,  OZAKI ASAICHIRO

IPC分类号： C12P13/14 ,  C12D13/06

CPC分类号： C12P13/14 ,  Y10S435/822 ,  Y10S435/858

摘要： L-Glutamic acid is produced by fermentation of culture media containing methanol as the main or sole carbon source by certain strains of microorganisms of the genera Methanomonas, Protaminobacter, and Microcyclus. The glutamic acid yield is improved by the presence of thiamine in the medium, and thiamine is required for growth of some of the microorganisms.

摘要翻译： L-谷氨酸是通过发酵含有甲醇作为主要或唯一碳源的培养基，通过某些Methanomonas属，Protaminobacter属和Microcyclus属微生物菌株发酵的。 通过培养基中硫胺素的存在可以提高谷氨酸的产量，硫胺素是生长一些微生物所必需的。