公开(公告)号：US11648305B2

公开(公告)日：2023-05-16

申请号：US16909040

申请日：2020-06-23

申请人： Altimmune UK Limited

发明人： Carlton Bradley Brown ,  Bertrand Victor Gilbert Georges ,  Jean Francois Thaburet

IPC分类号： A61K39/145 ,  A61K39/00 ,  A61K39/385 ,  A61K47/64 ,  A61K39/12 ,  C12N7/00

CPC分类号： A61K39/145 ,  A61K39/00 ,  A61K39/12 ,  A61K39/385 ,  A61K47/646 ,  C12N7/00 ,  A61K2039/54 ,  A61K2039/541 ,  A61K2039/542 ,  A61K2039/544 ,  A61K2039/60 ,  A61K2039/6093 ,  C12N2760/16034 ,  C12N2760/16122 ,  C12N2760/16134 ,  Y02A50/30

摘要： The invention provides an aqueous acidic formulation suitable for use as in the preparation of a pharmaceutically acceptable fluorocarbon-linked peptide formulation, which aqueous formulation comprises a first fluorocarbon-linked peptide, wherein: the peptide linked to the fluorocarbon is at least 20 amino acid residues long, comprises at least 50% hydrophobic amino acid residues and has an isoelectric point greater than or equal to 7; and the fluorocarbon-linked peptide is present in micelles.

公开(公告)号：US10729759B2

公开(公告)日：2020-08-04

申请号：US14807606

申请日：2015-07-23

申请人： ALTIMMUNE UK LIMITED

发明人： Carlton Bradley Brown ,  Bertrand Victor Gilbert Georges ,  Jean Francois Thaburet

IPC分类号： A61K38/00 ,  A61K38/16 ,  A61K38/10 ,  A61K9/00 ,  A61K39/12 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  A61K39/145 ,  A61K39/00 ,  A61K39/385 ,  A61K47/64 ,  C12N7/00

摘要： The invention provides an aqueous acidic formulation suitable for use as in the preparation of a pharmaceutically acceptable fluorocarbon-linked peptide formulation, which aqueous formulation comprises a first fluorocarbon-linked peptide, wherein: the peptide linked to the fluorocarbon is at least 20 amino acid residues long, comprises at least 50% hydrophobic amino acid residues and has an isoelectric point greater than or equal to 7; and the fluorocarbon-linked peptide is present in micelles.

公开(公告)号：US20210038710A1

公开(公告)日：2021-02-11

申请号：US16909040

申请日：2020-06-23

申请人： Altimmune UK Limited

发明人： Carlton Bradley Brown ,  Bertrand Victor Gilbert Georges ,  Jean Francois Thaburet

IPC分类号： A61K39/145 ,  A61K39/00 ,  A61K39/385 ,  A61K47/64 ,  A61K39/12 ,  C12N7/00

摘要： The invention provides an aqueous acidic formulation suitable for use as in the preparation of a pharmaceutically acceptable fluorocarbon-linked peptide formulation, which aqueous formulation comprises a first fluorocarbon-linked peptide, wherein: the peptide linked to the fluorocarbon is at least 20 amino acid residues long, comprises at least 50% hydrophobic amino acid residues and has an isoelectric point greater than or equal to 7; and the fluorocarbon-linked peptide is present in micelles.