公开(公告)号：US11447451B2

公开(公告)日：2022-09-20

申请号：US16878491

申请日：2020-05-19

申请人： AM Chemicals LLC

发明人： Andrei Pavel Guzaev ,  Vladimir Y. VVedenskiy ,  Khirud Gogoi

IPC分类号： C07D211/22 ,  C07F9/59 ,  C07F9/6561 ,  C07F9/6558 ,  C07F9/568 ,  C07F9/24 ,  C07D205/04 ,  C07D401/12 ,  C07D409/06 ,  C07D491/18 ,  C07D493/10 ,  C07D495/04 ,  C07H1/00 ,  C07H15/26 ,  C07H21/00 ,  C07J43/00

摘要： Novel non-nucleoside solid supports and phosphoramidite building blocks for preparation of synthetic oligonucleotides containing at least one non-nucleosidic moiety conjugated to a ligand of practical interest and synthetic processes for making the same are disclosed. Furthermore, oligomeric compounds are prepared using said solid supports and phosphoramidite building blocks, preferably followed by removal of protecting groups to provide oligonucleotides conjugated to ligands of interest.

公开(公告)号：US20200277260A1

公开(公告)日：2020-09-03

申请号：US16878491

申请日：2020-05-19

申请人： AM Chemicals LLC

发明人： Andrei Pavel Guzaev ,  Vladimir Y. VVedenskiy ,  Khirud Gogoi

IPC分类号： C07D211/22 ,  C07F9/59 ,  C07F9/6561 ,  C07F9/6558 ,  C07F9/568 ,  C07F9/24 ,  C07D205/04 ,  C07D401/12 ,  C07D409/06 ,  C07D491/18 ,  C07D493/10 ,  C07D495/04 ,  C07H1/00 ,  C07H15/26 ,  C07H21/00 ,  C07J43/00

摘要： Novel non-nucleoside solid supports and phosphoramidite building blocks for preparation of synthetic oligonucleotides containing at least one non-nucleosidic moiety conjugated to a ligand of practical interest and synthetic processes for making the same are disclosed. Furthermore, oligomeric compounds are prepared using said solid supports and phosphoramidite building blocks, preferably followed by removal of protecting groups to provide oligonucleotides conjugated to ligands of interest.