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11 条记录 (耗时 0.028 秒)

    Non-Natural Amino Acid Replication-Dependent Microorganisms and Vaccines
    1.
    发明申请
    Non-Natural Amino Acid Replication-Dependent Microorganisms and Vaccines 有权
    非天然氨基酸复制微生物和疫苗

    公开(公告)号：US20130280301A1

    公开(公告)日：2013-10-24

    申请号：US13936201

    申请日：2013-07-07

    申请人： AMBRX, INC.

    发明人： Feng TIAN ,  Brad HEHLI

    IPC分类号： A61K39/108

    CPC分类号： C12N15/70 ,  A61K39/0258 ,  C12N1/36 ,  C12N9/93

    摘要： Compositions and methods of producing vaccines, including methods wherein whole organism vaccines are provided with limited replication abilities, thereby increasing vaccine safety and efficacy, through the use of non-natural, unnatural, or non-naturally encoded amino acids.

    摘要翻译： 制备疫苗的组合物和方法，包括通过使用非天然的，非天然的或非天然编码的氨基酸使整个生物体疫苗具有有限的复制能力，从而增加疫苗安全性和功效的方法。

    COMPOSITIONS CONTAINING, METHODS AND USES OF ANTIBODY-TLR AGONIST CONJUGATES
    2.
    发明申请
    COMPOSITIONS CONTAINING, METHODS AND USES OF ANTIBODY-TLR AGONIST CONJUGATES 有权

    公开(公告)号：US20220226488A1

    公开(公告)日：2022-07-21

    申请号：US17429911

    申请日：2020-02-12

    申请人： Ambrx, Inc.

    发明人： Sung-Ju MOON ,  Brian LEON ,  Mingchao KANG ,  Nickolas KNUDSEN ,  Jianing WANG ,  Sukumar SAKAMURI ,  Feng TIAN

    IPC分类号： A61K47/68 ,  A61P37/04 ,  A61P35/00 ,  C07D471/04 ,  C07D471/14 ,  C07D473/18 ,  C07D473/34 ,  C07D487/04 ,  C07D487/14 ,  C07D519/00

    摘要： Disclosed herein are Trastuzumab-linked TLR-agonist derivative analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The Trastuzumab-linked TLR-agonist derivative analogs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid Trastuzumab-linked TLR-agonist derivative analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such Trastuzumab-linked TLR-agonist derivative analogs. Typically, the modified Trastuzumab-linked TLR-agonist derivative analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid Trastuzumab-linked TLR-agonist derivative analogs and modified non-natural amino acid Trastuzumab-linked TLR-agonist derivative analogs, including therapeutic, diagnostic, and other biotechnology use.

    Suppressor tRNA Transcription in Vertebrate Cells
    4.
    发明申请
    Suppressor tRNA Transcription in Vertebrate Cells 审中-公开
    抑制子tRNA转录在脊椎动物细胞

    公开(公告)号：US20140045259A1

    公开(公告)日：2014-02-13

    申请号：US13851911

    申请日：2013-03-27

    申请人： AMBRX, INC.

    发明人： Feng TIAN ,  Thea NORMAN ,  Stephanie CHU

    IPC分类号： C12N15/85

    CPC分类号： C12N15/85 ,  C12N9/93 ,  C12N15/11 ,  C12P21/02

    摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided.

    摘要翻译： 本发明提供用于生产翻译成分的组合物和方法，其扩展脊椎动物细胞中遗传编码氨基酸的数目。 组分包括正交tRNA，正交氨酰-tRNA合成酶，tRNA /合成酶和非天然氨基酸的正交对。 还提供了在脊椎动物细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。

    Hybrid Suppressor tRNA for Vertebrate Cells
    6.
    发明申请
    Hybrid Suppressor tRNA for Vertebrate Cells 审中-公开

    公开(公告)号：US20170096696A1

    公开(公告)日：2017-04-06

    申请号：US14820318

    申请日：2015-08-06

    申请人： AMBRX, INC.

    发明人： Feng TIAN ,  Thea NORMAN ,  Stephanie CHU

    IPC分类号： C12P21/02

    CPC分类号： C12P21/02 ,  C12N9/93 ,  C12N15/11

    摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided. The present invention provides vertebrate cells with translation components, e.g., pairs of orthogonal aminoacyl-tRNA synthetases (O-RSs) and orthogonal tRNA's (O-tRNA's) and individual components thereof, that are used in vertebrate protein biosynthetic machinery to incorporate an unnatural amino acid in a growing polypeptide chain, in a vertebrate cell.