公开(公告)号：US20190247579A1

公开(公告)日：2019-08-15

申请号：US16151720

申请日：2018-10-04

Applicant: AMGEN INC.

Inventor： Yasaman Damestani ,  Bryton De Guia ,  Martin Hering ,  Matthew Wayne Janke ,  Jerome Olivas ,  David Plescia ,  Brendan Smyth ,  Guojie Song

IPC: A61M5/20 ,  A61M5/31

CPC classification number: A61M5/20 ,  A61M5/3129 ,  A61M2005/3142 ,  B29L2031/7544

Abstract: A testing assembly for a drug delivery device is disclosed. The testing assembly can include a pressure vessel having a sealed pressure chamber that is configured to be pressurized to a predetermined pressure. The pressure vessel further defines an injection opening extending from an exterior thereof to the pressure chamber. A pierceable barrier extends over and seals the injection opening. The testing assembly further includes a measurement device disposed within the pressure chamber and a container aligned with the injection opening, such that the container is configured to collect a dose of a drug delivered via a drug delivery device through the pierceable barrier and the measurement device is configured to measure the dose of the drug.

公开(公告)号：US11541183B2

公开(公告)日：2023-01-03

申请号：US16615005

申请日：2018-06-12

Applicant: AMGEN INC.

Inventor： Martin Hering ,  Brendan Smyth

IPC: A61M5/315 ,  A61M5/145 ,  A61M5/31

Abstract: A drug delivery device includes a container for storing a drug having a longitudinal axis. A plunger rod aligned with the longitudinal axis of the container has a first end and a second end, where the second end is disposed within the container. A stopper is disposed in and movable relative to the container for expelling the drug, and a drive mechanism is operatively coupled to the first end of the plunger rod. The drive mechanism is configured to deliver a drive force to move the plunger rod along the longitudinal axis and through the container. A chamber disposed between a plunger rod and the stopper is adapted to oppose the drive force of the drive mechanism.

公开(公告)号：US11385140B2

公开(公告)日：2022-07-12

申请号：US16151720

申请日：2018-10-04

Applicant: AMGEN INC.

Inventor： Yasaman Damestani ,  Bryton De Guia ,  Martin Hering ,  Matthew Wayne Janke ,  Jerome Olivas ,  David Plescia ,  Brendan Smyth ,  Guojie Song

IPC: G01M99/00 ,  G01F25/00 ,  F04B51/00 ,  A61M5/00 ,  G01L25/00 ,  A61M5/20 ,  B29L31/00 ,  A61M5/31 ,  A61M5/142

Abstract: A testing assembly for a drug delivery device is disclosed. The testing assembly can include a pressure vessel having a sealed pressure chamber that is configured to be pressurized to a predetermined pressure. The pressure vessel further defines an injection opening extending from an exterior thereof to the pressure chamber. A pierceable barrier extends over and seals the injection opening. The testing assembly further includes a measurement device disposed within the pressure chamber and a container aligned with the injection opening, such that the container is configured to collect a dose of a drug delivered via a drug delivery device through the pierceable barrier and the measurement device is configured to measure the dose of the drug.