公开(公告)号：US20190247579A1

公开(公告)日：2019-08-15

申请号：US16151720

申请日：2018-10-04

Applicant: AMGEN INC.

Inventor： Yasaman Damestani ,  Bryton De Guia ,  Martin Hering ,  Matthew Wayne Janke ,  Jerome Olivas ,  David Plescia ,  Brendan Smyth ,  Guojie Song

IPC: A61M5/20 ,  A61M5/31

CPC classification number: A61M5/20 ,  A61M5/3129 ,  A61M2005/3142 ,  B29L2031/7544

Abstract: A testing assembly for a drug delivery device is disclosed. The testing assembly can include a pressure vessel having a sealed pressure chamber that is configured to be pressurized to a predetermined pressure. The pressure vessel further defines an injection opening extending from an exterior thereof to the pressure chamber. A pierceable barrier extends over and seals the injection opening. The testing assembly further includes a measurement device disposed within the pressure chamber and a container aligned with the injection opening, such that the container is configured to collect a dose of a drug delivered via a drug delivery device through the pierceable barrier and the measurement device is configured to measure the dose of the drug.

公开(公告)号：US20200254172A1

公开(公告)日：2020-08-13

申请号：US16753711

申请日：2018-10-01

Applicant: AMGEN INC.

Inventor： Ronald Forster ,  Gregory Gordon ,  Martin Hering ,  Matthew Wayne Janke ,  Andrew N. King ,  Wael Mismar

IPC: A61M5/145 ,  A61M5/315 ,  A61M5/142

Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a housing, a container, a trigger member, and an interlock assembly. The trigger member may be selectively moveable relative to the housing to activate operation of at least one activatable element of the drug delivery device. The interlock assembly may include a lever mounted rotatably relative to the housing, a proximity sensor moveable between a first position extending beyond an exterior surface of the housing and a second position retracted toward the housing, and a rotational biasing member operably connected to the proximity sensor via the lever. When the proximity sensor is in the first position, the interlock assembly may limit movement of the trigger member relative to the housing. The rotational biasing member may be configured to exert a torque biasing the proximity sensor toward the first sensor position.

公开(公告)号：US20200206429A1

公开(公告)日：2020-07-02

申请号：US16615005

申请日：2017-12-06

Applicant: AMGEN INC

Inventor： Martin Hering ,  Brendan SMYTH

IPC: A61M5/315 ,  A61M5/145

Abstract: A drug delivery device includes a container for storing a drug having a longitudinal axis. A plunger rod aligned with the longitudinal axis of the container has a first end and a second end, where the second end is disposed within the container. A stopper is disposed in and movable relative to the container for expelling the drug, and a drive mechanism is operatively coupled to the first end of the plunger rod. The drive mechanism is configured to deliver a drive force to move the plunger rod along the longitudinal axis and through the container. A chamber disposed between a plunger rod and the stopper is adapted to oppose the drive force of the drive mechanism.

公开(公告)号：US11813426B2

公开(公告)日：2023-11-14

申请号：US16753711

申请日：2018-10-01

Applicant: AMGEN INC.

Inventor： Ronald Forster ,  Gregory Gordon ,  Martin Hering ,  Matthew Wayne Janke ,  Andrew N. King ,  Wael Mismar

IPC: A61M5/142 ,  A61M5/145 ,  A61M5/315 ,  A61M5/158

CPC classification number: A61M5/14248 ,  A61M5/1456 ,  A61M5/31571 ,  A61M2005/14256 ,  A61M2005/14506 ,  A61M2005/1585 ,  A61M2005/3154 ,  A61M2205/583

Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a housing, a container, a trigger member, and an interlock assembly. The trigger member may be selectively moveable relative to the housing to activate operation of at least one activatable element of the drug delivery device. The interlock assembly may include a lever mounted rotatably relative to the housing, a proximity sensor moveable between a first position extending beyond an exterior surface of the housing and a second position retracted toward the housing, and a rotational biasing member operably connected to the proximity sensor via the lever. When the proximity sensor is in the first position, the interlock assembly may limit movement of the trigger member relative to the housing. The rotational biasing member may be configured to exert a torque biasing the proximity sensor toward the first sensor position.

公开(公告)号：US11541183B2

公开(公告)日：2023-01-03

申请号：US16615005

申请日：2018-06-12

Applicant: AMGEN INC.

Inventor： Martin Hering ,  Brendan Smyth

IPC: A61M5/315 ,  A61M5/145 ,  A61M5/31

Abstract: A drug delivery device includes a container for storing a drug having a longitudinal axis. A plunger rod aligned with the longitudinal axis of the container has a first end and a second end, where the second end is disposed within the container. A stopper is disposed in and movable relative to the container for expelling the drug, and a drive mechanism is operatively coupled to the first end of the plunger rod. The drive mechanism is configured to deliver a drive force to move the plunger rod along the longitudinal axis and through the container. A chamber disposed between a plunger rod and the stopper is adapted to oppose the drive force of the drive mechanism.

公开(公告)号：US11385140B2

公开(公告)日：2022-07-12

申请号：US16151720

申请日：2018-10-04

Applicant: AMGEN INC.

Inventor： Yasaman Damestani ,  Bryton De Guia ,  Martin Hering ,  Matthew Wayne Janke ,  Jerome Olivas ,  David Plescia ,  Brendan Smyth ,  Guojie Song

IPC: G01M99/00 ,  G01F25/00 ,  F04B51/00 ,  A61M5/00 ,  G01L25/00 ,  A61M5/20 ,  B29L31/00 ,  A61M5/31 ,  A61M5/142

Abstract: A testing assembly for a drug delivery device is disclosed. The testing assembly can include a pressure vessel having a sealed pressure chamber that is configured to be pressurized to a predetermined pressure. The pressure vessel further defines an injection opening extending from an exterior thereof to the pressure chamber. A pierceable barrier extends over and seals the injection opening. The testing assembly further includes a measurement device disposed within the pressure chamber and a container aligned with the injection opening, such that the container is configured to collect a dose of a drug delivered via a drug delivery device through the pierceable barrier and the measurement device is configured to measure the dose of the drug.