公开(公告)号：US11617837B2

公开(公告)日：2023-04-04

申请号：US16624706

申请日：2018-07-11

Applicant: AMGEN INC.

Inventor： Jerome Olivas ,  Guojie Song ,  Sudeshna Dutta Ray

IPC: A61M5/315 ,  A61M5/24 ,  A61M5/145

Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a main housing having an interior surface defining an enclosed space, and an exterior surface releasably attachable to a patient. A container may be disposed in the enclosed space and include a reservoir containing a drug and a stopper. A drive assembly may also be disposed in the enclosed space and configured to move the stopper through the reservoir to expel the drug from the reservoir. The drive assembly may include a rotational power source and a gear module. The gear module may include a mounting plate and a plurality of gears rotatably connected to the mounting plate. Furthermore, the mounting plate may be separate from the main housing.

公开(公告)号：US20220008652A1

公开(公告)日：2022-01-13

申请号：US17359825

申请日：2021-06-28

Applicant: AMGEN INC.

Inventor： Ali Nekouzadeh ,  Jerome Olivas ,  Joshua Merilos ,  Matthew Wayne Janke ,  Justin Harris ,  Marc Orloff ,  Edward Stapleford Nielsen ,  Chitra Nadig ,  Yasaman Damestani ,  Guojie Song ,  Bryton De Guia

IPC: A61M5/142 ,  A61M5/20

Abstract: An adhesive patch for a drug delivery device with a bacteria impermeable sterility margin surrounding an edge surface of the adhesive patch is disclosed, as well as a drug delivery device fixed to such an adhesive patch and a method of assembling a drug delivery device with such an adhesive patch. In some arrangements, the sterility margin is attached to or integral with a lower liner on a lower surface of the adhesive patch. In other arrangements, the sterility margin is attached to or integral with an upper liner on an upper surface of the adhesive patch.

公开(公告)号：US11077246B2

公开(公告)日：2021-08-03

申请号：US16049850

申请日：2018-07-31

Applicant: AMGEN INC.

Inventor： Ali Nekouzadeh ,  Jerome Olivas ,  Joshua Merilos ,  Matthew Wayne Janke ,  Justin Harris ,  Marc Orloff ,  Edward Stapleford Nielsen ,  Chitra Nadig ,  Yasaman Damestani ,  Guojie Song ,  Bryton De Guia

IPC: A61M5/142 ,  A61M5/20

Abstract: An adhesive patch for a drug delivery device with a bacteria impermeable sterility margin surrounding an edge surface of the adhesive patch is disclosed, as well as a drug delivery device fixed to such an adhesive patch and a method of assembling a drug delivery device with such an adhesive patch. In some arrangements, the sterility margin is attached to or integral with a lower liner on a lower surface of the adhesive patch. In other arrangements, the sterility margin is attached to or integral with an upper liner on an upper surface of the adhesive patch.

公开(公告)号：US11385140B2

公开(公告)日：2022-07-12

申请号：US16151720

申请日：2018-10-04

Applicant: AMGEN INC.

Inventor： Yasaman Damestani ,  Bryton De Guia ,  Martin Hering ,  Matthew Wayne Janke ,  Jerome Olivas ,  David Plescia ,  Brendan Smyth ,  Guojie Song

IPC: G01M99/00 ,  G01F25/00 ,  F04B51/00 ,  A61M5/00 ,  G01L25/00 ,  A61M5/20 ,  B29L31/00 ,  A61M5/31 ,  A61M5/142

Abstract: A testing assembly for a drug delivery device is disclosed. The testing assembly can include a pressure vessel having a sealed pressure chamber that is configured to be pressurized to a predetermined pressure. The pressure vessel further defines an injection opening extending from an exterior thereof to the pressure chamber. A pierceable barrier extends over and seals the injection opening. The testing assembly further includes a measurement device disposed within the pressure chamber and a container aligned with the injection opening, such that the container is configured to collect a dose of a drug delivered via a drug delivery device through the pierceable barrier and the measurement device is configured to measure the dose of the drug.

公开(公告)号：US20190083702A1

公开(公告)日：2019-03-21

申请号：US16049850

申请日：2018-07-31

Applicant: AMGEN INC.

Inventor： Ali Nekouzadeh ,  Jerome Olivas ,  Joshua Merilos ,  Matthew Wayne Janke ,  Justin Harris ,  Marc Orloff ,  Edward Stapleford Nielsen ,  Chitra Nadig ,  Yasaman Damestani ,  Guojie Song ,  Bryton De Guia

IPC: A61M5/142 ,  A61M5/20

Abstract: An adhesive patch for a drug delivery device with a bacteria impermeable sterility margin surrounding an edge surface of the adhesive patch is disclosed, as well as a drug delivery device fixed to such an adhesive patch and a method of assembling a drug delivery device with such an adhesive patch. In some arrangements, the sterility margin is attached to or integral with a lower liner on a lower surface of the adhesive patch. In other arrangements, the sterility margin is attached to or integral with an upper liner on an upper surface of the adhesive patch.

公开(公告)号：US12178991B2

公开(公告)日：2024-12-31

申请号：US17359825

申请日：2021-06-28

Applicant: AMGEN INC.

Inventor： Ali Nekouzadeh ,  Jerome Olivas ,  Joshua Merilos ,  Matthew Wayne Janke ,  Justin Harris ,  Marc Orloff ,  Edward Stapleford Nielsen ,  Chitra Nadig ,  Yasaman Damestani ,  Guojie Song ,  Bryton De Guia

IPC: A61M5/142 ,  A61M5/20

Abstract: An adhesive patch for a drug delivery device with a bacteria impermeable sterility margin surrounding an edge surface of the adhesive patch is disclosed, as well as a drug delivery device fixed to such an adhesive patch and a method of assembling a drug delivery device with such an adhesive patch. In some arrangements, the sterility margin is attached to or integral with a lower liner on a lower surface of the adhesive patch. In other arrangements, the sterility margin is attached to or integral with an upper liner on an upper surface of the adhesive patch.

公开(公告)号：US20230241321A1

公开(公告)日：2023-08-03

申请号：US18118881

申请日：2023-03-08

Applicant: AMGEN INC.

Inventor： Jerome Olivas ,  Guojie Song ,  Sudeshna Dutta Ray

IPC: A61M5/315 ,  A61M5/24

CPC classification number: A61M5/31511 ,  A61M5/24 ,  A61M5/31575 ,  A61M2005/3152 ,  A61M2005/14506

Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a main housing having an interior surface defining an enclosed space, and an exterior surface releasably attachable to a patient. A container may be disposed in the enclosed space and include a reservoir containing a drug and a stopper. A drive assembly may also be disposed in the enclosed space and configured to move the stopper through the reservoir to expel the drug from the reservoir. The drive assembly may include a rotational power source and a gear module. The gear module may include a mounting plate and a plurality of gears rotatably connected to the mounting plate. Furthermore, the mounting plate may be separate from the main housing.

公开(公告)号：US20210154410A1

公开(公告)日：2021-05-27

申请号：US16624706

申请日：2018-07-11

Applicant: AMGEN INC.

Inventor： Jerome Olivas ,  Guojie Song ,  Sudeshna Dutta Ray

IPC: A61M5/315 ,  A61M5/24

Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a main housing having an interior surface defining an enclosed space, and an exterior surface releasably attachable to a patient. A container may be disposed in the enclosed space and include a reservoir containing a drug and a stopper. A drive assembly may also be disposed in the enclosed space and configured to move the stopper through the reservoir to expel the drug from the reservoir. The drive assembly may include a rotational power source and a gear module. The gear module may include a mounting plate and a plurality of gears rotatably connected to the mounting plate. Furthermore, the mounting plate may be separate from the main housing.

公开(公告)号：US20190247579A1

公开(公告)日：2019-08-15

申请号：US16151720

申请日：2018-10-04

Applicant: AMGEN INC.

Inventor： Yasaman Damestani ,  Bryton De Guia ,  Martin Hering ,  Matthew Wayne Janke ,  Jerome Olivas ,  David Plescia ,  Brendan Smyth ,  Guojie Song

IPC: A61M5/20 ,  A61M5/31

CPC classification number: A61M5/20 ,  A61M5/3129 ,  A61M2005/3142 ,  B29L2031/7544

Abstract: A testing assembly for a drug delivery device is disclosed. The testing assembly can include a pressure vessel having a sealed pressure chamber that is configured to be pressurized to a predetermined pressure. The pressure vessel further defines an injection opening extending from an exterior thereof to the pressure chamber. A pierceable barrier extends over and seals the injection opening. The testing assembly further includes a measurement device disposed within the pressure chamber and a container aligned with the injection opening, such that the container is configured to collect a dose of a drug delivered via a drug delivery device through the pierceable barrier and the measurement device is configured to measure the dose of the drug.