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公开(公告)号：US11773184B2
公开(公告)日：2023-10-03
申请号：US16799601
申请日：2020-02-24
Applicant: AMGEN INC.
Inventor： Twinkle R. Christian , Christi L. Clogston , Timothy David Osslund
IPC: C07K16/40 , A61K39/395
CPC classification number: C07K16/40 , A61K39/39591 , C07K2317/565
Abstract: Described herein are anti-PCSK9 antibody crystals, methods of making such antibody crystals and formulations comprising the antibody crystals.
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公开(公告)号：US11459401B2
公开(公告)日：2022-10-04
申请号：US16337325
申请日：2017-10-06
Applicant: AMGEN INC.
Inventor： Alona Teran , Qahera Munaim , Nazer Khalaf , Rahul Rajan Kaushik , Christi L. Clogston , Twinkle R. Christian , William J. Callahan
Abstract: Described herein are therapeutic protein formulations comprising N-methyl pyrrolidone (NMP), methods related to reducing viscosity of pharmaceutical formulations and methods related to stabilizing pharmaceutical formulations using NMP.
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Patent Agency Ranking
公开(公告)号：US20200024363A1
公开(公告)日：2020-01-23
申请号：US16337325
申请日：2017-10-06
Applicant: AMGEN INC.
Inventor： Alona Teran , Qahera Muniam , Nazer Khalaf , Rahul Rajan Kaushik , Christi L. Clogston , Twinkle R. Christian , William J. Callahan
Abstract: Described herein are therapeutic protein formulations comprising N-methyl pyrrolidone (NMP), methods related to reducing viscosity of pharmaceutical formulations and methods related to stabilizing pharmaceutical formulations using NMP.
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公开(公告)号：US20160083460A1
公开(公告)日：2016-03-24
申请号：US14832268
申请日：2015-08-21
Applicant: AMGEN INC.
Inventor： Christi L. Clogston , Twinkle R. Christian , Timothy D. Osslund , Elisabeth Freeman
IPC: C07K16/18
CPC classification number: C07K16/18 , A61K39/39591 , A61K2039/505 , C07K16/22 , C07K2317/56 , C07K2317/76
Abstract: Described herein are anti-sclerostin antibody crystals, methods of making such antibody crystals and formulations comprising the antibody crystals.
Abstract translation: 本文描述了抗硬化蛋白抗体结晶，制备这种抗体结晶的方法和包含抗体晶体的制剂。
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公开(公告)号：US20210047434A1
公开(公告)日：2021-02-18
申请号：US17011433
申请日：2020-09-03
Applicant: Amgen Inc.
Inventor： Joyce Chi Yee Chan , John P. Gibbs , Clapton S. Dias , Scott Wasserman , Robert Andrew Donald Scott , Christi L. Clogston , Timothy David Osslund , Evan A. Stein
IPC: C07K16/40 , A61K39/395
Abstract: The present invention relates to methods of treating or preventing cholesterol related disorders, such as hypercholesterolemia, hyperlipidemia or dyslipidemia, using antibodies against proprotein convertase subtilisin/kexin type 9 (PCSK9). Formulations and methods of producing said formulations are also described.
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公开(公告)号：US09617333B2
公开(公告)日：2017-04-11
申请号：US14832268
申请日：2015-08-21
Applicant: AMGEN INC.
Inventor： Christi L. Clogston , Twinkle R. Christian , Timothy D. Osslund , Elisabeth Freeman
IPC: C07K16/18 , A61K39/35 , C07K16/22 , A61K39/395 , A61K39/00
CPC classification number: C07K16/18 , A61K39/39591 , A61K2039/505 , C07K16/22 , C07K2317/56 , C07K2317/76
Abstract: Described herein are anti-sclerostin antibody crystals, methods of making such antibody crystals and formulations comprising the antibody crystals.
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公开(公告)号：US20140030270A1
公开(公告)日：2014-01-30
申请号：US13886180
申请日：2013-05-02
Applicant: Amgen Inc.
Inventor： Christi L. Clogston , Timothy David Osslund
IPC: C07K16/40
CPC classification number: C07K16/40 , A61K2039/505 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: The present invention relates to methods of treating or preventing cholesterol related disorders, such as hypercholesterolemia, hyperlipidemia or dyslipidemia, using antibodies against proprotein convertase subtilisin/kexin type 9 (PCSK9). Formulations and methods of producing said formulations are also described.
Abstract translation: 本发明涉及使用抗前驱蛋白转化酶枯草杆菌蛋白酶/ 9型（KKK）的抗体来治疗或预防胆固醇相关疾病如高胆固醇血症，高脂血症或血脂异常的方法。 还描述了制备所述制剂的制剂和方法。
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