公开(公告)号：US10166189B2

公开(公告)日：2019-01-01

申请号：US15011229

申请日：2016-01-29

Applicant: AMGEN INC.

Inventor： William J. Callahan ,  Richard L. Remmele, Jr. ,  Gayathri Ratnaswamy ,  Ramil F. Latypov ,  Dingjiang Liu

IPC: A61K39/395 ,  A61K9/19 ,  A61K38/10 ,  A61K38/16 ,  A61K47/22 ,  A61K47/26

Abstract: The present invention provides long-term stable formulations of a lyophilized therapeutic peptibody and methods for making a lyophilized composition comprising a therapeutic peptibody.

公开(公告)号：US12156900B2

公开(公告)日：2024-12-03

申请号：US16764463

申请日：2018-11-16

Applicant: Amgen Inc.

Inventor： Yael Wexler-Cohen ,  William J. Callahan ,  Robert Matthew Fesinmeyer ,  Rahul Rajan Kaushik ,  Sai Chakradhar Padala

IPC: A61K38/18 ,  A61K9/00 ,  A61K47/02 ,  A61K47/14 ,  A61K47/18 ,  A61K47/26 ,  A61K47/34

Abstract: Protein formulations and methods of making and using such formulations are provided herein. The formulation can be an ophthalmic formulation, such as for intravitreal administration. In some embodiments, the formulation comprises a VEGFR-Fc fusion protein, such as aflibercept.

公开(公告)号：US20200024363A1

公开(公告)日：2020-01-23

申请号：US16337325

申请日：2017-10-06

Applicant: AMGEN INC.

Inventor： Alona Teran ,  Qahera Muniam ,  Nazer Khalaf ,  Rahul Rajan Kaushik ,  Christi L. Clogston ,  Twinkle R. Christian ,  William J. Callahan

IPC: C07K16/40 ,  A61K9/19 ,  A61K47/22 ,  A61K47/18 ,  A61K47/24 ,  A61K47/26 ,  A61K47/42

Abstract: Described herein are therapeutic protein formulations comprising N-methyl pyrrolidone (NMP), methods related to reducing viscosity of pharmaceutical formulations and methods related to stabilizing pharmaceutical formulations using NMP.

公开(公告)号：US12247071B2

公开(公告)日：2025-03-11

申请号：US17820958

申请日：2022-08-19

Applicant: Amgen Inc.

Inventor： William J. Callahan ,  Rahul Rajan Kaushik ,  Joy Brennan

IPC: C07K16/24 ,  A61K9/00 ,  A61K9/08 ,  A61K47/10 ,  A61K47/18

Abstract: Stable adalimumab formulations are disclosed.

公开(公告)号：US11459401B2

公开(公告)日：2022-10-04

申请号：US16337325

申请日：2017-10-06

Applicant: AMGEN INC.

Inventor： Alona Teran ,  Qahera Munaim ,  Nazer Khalaf ,  Rahul Rajan Kaushik ,  Christi L. Clogston ,  Twinkle R. Christian ,  William J. Callahan

IPC: A61K39/395 ,  C07K16/40 ,  A61K9/19 ,  A61K47/18 ,  A61K47/22 ,  A61K47/24 ,  A61K47/26 ,  A61K47/42

Abstract: Described herein are therapeutic protein formulations comprising N-methyl pyrrolidone (NMP), methods related to reducing viscosity of pharmaceutical formulations and methods related to stabilizing pharmaceutical formulations using NMP.