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公开(公告)号：US10166189B2
公开(公告)日：2019-01-01
申请号：US15011229
申请日：2016-01-29
申请人： AMGEN INC.
发明人： William J. Callahan , Richard L. Remmele, Jr. , Gayathri Ratnaswamy , Ramil F. Latypov , Dingjiang Liu
摘要： The present invention provides long-term stable formulations of a lyophilized therapeutic peptibody and methods for making a lyophilized composition comprising a therapeutic peptibody.
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公开(公告)号：US11459401B2
公开(公告)日：2022-10-04
申请号：US16337325
申请日：2017-10-06
申请人： AMGEN INC.
发明人： Alona Teran , Qahera Munaim , Nazer Khalaf , Rahul Rajan Kaushik , Christi L. Clogston , Twinkle R. Christian , William J. Callahan
IPC分类号： A61K39/395 , C07K16/40 , A61K9/19 , A61K47/18 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/42
摘要： Described herein are therapeutic protein formulations comprising N-methyl pyrrolidone (NMP), methods related to reducing viscosity of pharmaceutical formulations and methods related to stabilizing pharmaceutical formulations using NMP.
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公开(公告)号：US20200024363A1
公开(公告)日：2020-01-23
申请号：US16337325
申请日：2017-10-06
申请人： AMGEN INC.
发明人： Alona Teran , Qahera Muniam , Nazer Khalaf , Rahul Rajan Kaushik , Christi L. Clogston , Twinkle R. Christian , William J. Callahan
摘要： Described herein are therapeutic protein formulations comprising N-methyl pyrrolidone (NMP), methods related to reducing viscosity of pharmaceutical formulations and methods related to stabilizing pharmaceutical formulations using NMP.
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