公开(公告)号：US11459401B2

公开(公告)日：2022-10-04

申请号：US16337325

申请日：2017-10-06

申请人： AMGEN INC.

发明人： Alona Teran ,  Qahera Munaim ,  Nazer Khalaf ,  Rahul Rajan Kaushik ,  Christi L. Clogston ,  Twinkle R. Christian ,  William J. Callahan

IPC分类号： A61K39/395 ,  C07K16/40 ,  A61K9/19 ,  A61K47/18 ,  A61K47/22 ,  A61K47/24 ,  A61K47/26 ,  A61K47/42

摘要： Described herein are therapeutic protein formulations comprising N-methyl pyrrolidone (NMP), methods related to reducing viscosity of pharmaceutical formulations and methods related to stabilizing pharmaceutical formulations using NMP.

公开(公告)号：US11241502B2

公开(公告)日：2022-02-08

申请号：US16192469

申请日：2018-11-15

申请人： AMGEN INC.

发明人： Alona Teran ,  William Callahan ,  Qahera Munaim ,  Rahul Kaushik

IPC分类号： A61K47/60 ,  A61K38/07 ,  A61K47/26 ,  A61P35/00 ,  A61K47/02 ,  A61K9/00 ,  A61K47/18 ,  A61K9/19 ,  A61K47/42 ,  A61K47/12 ,  A61K9/08

摘要： The present invention provides stable pharmaceutical compositions of pegylated carfilzomib compounds, methods for preparing the compositions, and uses of the compositions for treating cancer, including hematologic malignancies such as multiple myeloma. The compositions can be stored in frozen form or lyophilized to dry solid form.

公开(公告)号：US20200024363A1

公开(公告)日：2020-01-23

申请号：US16337325

申请日：2017-10-06

申请人： AMGEN INC.

发明人： Alona Teran ,  Qahera Muniam ,  Nazer Khalaf ,  Rahul Rajan Kaushik ,  Christi L. Clogston ,  Twinkle R. Christian ,  William J. Callahan

IPC分类号： C07K16/40 ,  A61K9/19 ,  A61K47/22 ,  A61K47/18 ,  A61K47/24 ,  A61K47/26 ,  A61K47/42

摘要： Described herein are therapeutic protein formulations comprising N-methyl pyrrolidone (NMP), methods related to reducing viscosity of pharmaceutical formulations and methods related to stabilizing pharmaceutical formulations using NMP.