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公开(公告)号：US12178991B2
公开(公告)日：2024-12-31
申请号：US17359825
申请日：2021-06-28
Applicant: AMGEN INC.
Inventor： Ali Nekouzadeh , Jerome Olivas , Joshua Merilos , Matthew Wayne Janke , Justin Harris , Marc Orloff , Edward Stapleford Nielsen , Chitra Nadig , Yasaman Damestani , Guojie Song , Bryton De Guia
Abstract: An adhesive patch for a drug delivery device with a bacteria impermeable sterility margin surrounding an edge surface of the adhesive patch is disclosed, as well as a drug delivery device fixed to such an adhesive patch and a method of assembling a drug delivery device with such an adhesive patch. In some arrangements, the sterility margin is attached to or integral with a lower liner on a lower surface of the adhesive patch. In other arrangements, the sterility margin is attached to or integral with an upper liner on an upper surface of the adhesive patch.
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公开(公告)号：US20190083702A1
公开(公告)日：2019-03-21
申请号：US16049850
申请日：2018-07-31
Applicant: AMGEN INC.
Inventor： Ali Nekouzadeh , Jerome Olivas , Joshua Merilos , Matthew Wayne Janke , Justin Harris , Marc Orloff , Edward Stapleford Nielsen , Chitra Nadig , Yasaman Damestani , Guojie Song , Bryton De Guia
Abstract: An adhesive patch for a drug delivery device with a bacteria impermeable sterility margin surrounding an edge surface of the adhesive patch is disclosed, as well as a drug delivery device fixed to such an adhesive patch and a method of assembling a drug delivery device with such an adhesive patch. In some arrangements, the sterility margin is attached to or integral with a lower liner on a lower surface of the adhesive patch. In other arrangements, the sterility margin is attached to or integral with an upper liner on an upper surface of the adhesive patch.
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公开(公告)号：US12053618B2
公开(公告)日：2024-08-06
申请号：US16761149
申请日：2018-11-06
Applicant: AMGEN INC.
Inventor： Justin Harris , Matthew Wayne Janke , Wael Mismar , Jerome Olivas , Thomas Clark Pearson , Sudeshna Dutta Ray , Ryan M. Agard , Alexis Dechelette , Michael Gammelager , Mads Hansen , Valerio Mazzon , Owen Ryan , Clive Smith
CPC classification number: A61M5/28 , A61M5/1782 , A61M5/24 , A61M5/3134 , A61M2005/2488 , A61M2005/3115
Abstract: Fill-finish assemblies facilitating the manufacture of a drug delivery device are disclosed. The fill-finish assembly may include a container, an insertion mechanism, a fluid pathway connection assembly disposed between the container and the insertion mechanism, and a carrier. The insertion mechanism may include a delivery member and an insertion mechanism housing. The insertion mechanism may be configured to move the delivery member from a retracted position inside the insertion mechanism housing to a deployed position outside the insertion mechanism housing. The fluid pathway connection assembly may be selectively activatable to establish fluid communication between the container and the delivery member. The carrier may have a hollow interior containing at least a portion of each of the container, the insertion mechanism, and the fluid pathway connection assembly. The carrier may be configured to hold the container, the insertion mechanism, and the fluid pathway connection assembly in alignment with each other.
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公开(公告)号：US11464903B2
公开(公告)日：2022-10-11
申请号：US16649058
申请日：2018-08-21
Applicant: AMGEN INC.
Inventor： Justin Harris , Sudeshna Dutta Ray , Jerome Olivas
Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a main housing having an exterior surface releasably attachable to a patient, a container disposed in an enclosed space defined by an interior surface of the main housing, and a drive assembly. The container may include a reservoir containing a drug and a stopper. The drive assembly may include drive housing and a tether which slidably engages and is pulled taut against a guide surface of the drive housing. A first end of the tether may be wound around a capstan which is mounted rotatably relative to the drive housing. A second end of the tether may be operably connected to a stopper biasing member. The tether may initially retain the stopper biasing member in an energized state. When released, the stopper biasing member may expand to move the stopper through the reservoir.
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公开(公告)号：US11103636B2
公开(公告)日：2021-08-31
申请号：US16015568
申请日：2018-06-22
Applicant: AMGEN INC.
Inventor： Jerome Olivas , Justin Harris , Sudeshna Dutta Ray , David Coleman , Eoghan McManus
Abstract: An insertion mechanism for a wearable drug delivery device includes a needle hub, a needle coupled to the needle hub, a flexible boot removably coupled to the needle hub, and a cannula coupled to the flexible boot. The needle hub, the needle, the flexible boot, and the cannula are movable between a first position and a second position. Upon moving the needle hub, the needle, the flexible boot, and the cannula from the first position to the second position, the cannula engages a floor member to restrict movement of the cannula and the flexible movement towards the first position.
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Patent Agency Ranking
公开(公告)号：US20220008652A1
公开(公告)日：2022-01-13
申请号：US17359825
申请日：2021-06-28
Applicant: AMGEN INC.
Inventor： Ali Nekouzadeh , Jerome Olivas , Joshua Merilos , Matthew Wayne Janke , Justin Harris , Marc Orloff , Edward Stapleford Nielsen , Chitra Nadig , Yasaman Damestani , Guojie Song , Bryton De Guia
Abstract: An adhesive patch for a drug delivery device with a bacteria impermeable sterility margin surrounding an edge surface of the adhesive patch is disclosed, as well as a drug delivery device fixed to such an adhesive patch and a method of assembling a drug delivery device with such an adhesive patch. In some arrangements, the sterility margin is attached to or integral with a lower liner on a lower surface of the adhesive patch. In other arrangements, the sterility margin is attached to or integral with an upper liner on an upper surface of the adhesive patch.
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公开(公告)号：US11077246B2
公开(公告)日：2021-08-03
申请号：US16049850
申请日：2018-07-31
Applicant: AMGEN INC.
Inventor： Ali Nekouzadeh , Jerome Olivas , Joshua Merilos , Matthew Wayne Janke , Justin Harris , Marc Orloff , Edward Stapleford Nielsen , Chitra Nadig , Yasaman Damestani , Guojie Song , Bryton De Guia
Abstract: An adhesive patch for a drug delivery device with a bacteria impermeable sterility margin surrounding an edge surface of the adhesive patch is disclosed, as well as a drug delivery device fixed to such an adhesive patch and a method of assembling a drug delivery device with such an adhesive patch. In some arrangements, the sterility margin is attached to or integral with a lower liner on a lower surface of the adhesive patch. In other arrangements, the sterility margin is attached to or integral with an upper liner on an upper surface of the adhesive patch.
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公开(公告)号：US20200338271A1
公开(公告)日：2020-10-29
申请号：US16761149
申请日：2018-11-06
Applicant: AMGEN INC.
Inventor： Justin Harris , Matthew Wayne Janke , Wael Mismar , Jerome Olivas , Thomas Clark Pearson , Sudeshna Dutta Ray , Ryan M. Agard , Alexis Dechelette , Michael Gammelager , Mads Hansen , Valerio Mazzon , Owen Ryan , Clive Smith
Abstract: Fill-finish assemblies facilitating the manufacture of a drug delivery device are disclosed. The fill-finish assembly may include a container, an insertion mechanism, a fluid pathway connection assembly disposed between the container and the insertion mechanism, and a carrier. The insertion mechanism may include a delivery member and an insertion mechanism housing. The insertion mechanism may be configured to move the delivery member from a retracted position inside the insertion mechanism housing to a deployed position outside the insertion mechanism housing. The fluid pathway connection assembly may be selectively activatable to establish fluid communication between the container and the delivery member. The carrier may have a hollow interior containing at least a portion of each of the container, the insertion mechanism, and the fluid pathway connection assembly. The carrier may be configured to hold the container, the insertion mechanism, and the fluid pathway connection assembly in alignment with each other.
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公开(公告)号：US20200289745A1
公开(公告)日：2020-09-17
申请号：US16649058
申请日：2018-08-21
Applicant: AMGEN INC.
Inventor： Justin Harris , Sudeshna Dutta Ray , Jerome Olivas
Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a main housing having an exterior surface releasably attachable to a patient, a container disposed in an enclosed space defined by an interior surface of the main housing, and a drive assembly. The container may include a reservoir containing a drug and a stopper. The drive assembly may include drive housing and a tether which slidably engages and is pulled taut against a guide surface of the drive housing. A first end of the tether may be wound around a capstan which is mounted rotatably relative to the drive housing. A second end of the tether may be operably connected to a stopper biasing member. The tether may initially retain the stopper biasing member in an energized state. When released, the stopper biasing member may expand to move the stopper through the reservoir.
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公开(公告)号：US20190060562A1
公开(公告)日：2019-02-28
申请号：US16015568
申请日：2018-06-22
Applicant: AMGEN INC.
Inventor： Jerome Olivas , Justin Harris , Sudeshna Dutta Ray , David Coleman , Eoghan McManus
Abstract: An insertion mechanism for a wearable drug delivery device includes a needle hub, a needle coupled to the needle hub, a flexible boot removably coupled to the needle hub, and a cannula coupled to the flexible boot. The needle hub, the needle, the flexible boot, and the cannula are movable between a first position and a second position. Upon moving the needle hub, the needle, the flexible boot, and the cannula from the first position to the second position, the cannula engages a floor member to restrict movement of the cannula and the flexible movement towards the first position.
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