公开(公告)号：US11241502B2

公开(公告)日：2022-02-08

申请号：US16192469

申请日：2018-11-15

Applicant: AMGEN INC.

Inventor： Alona Teran ,  William Callahan ,  Qahera Munaim ,  Rahul Kaushik

IPC: A61K47/60 ,  A61K38/07 ,  A61K47/26 ,  A61P35/00 ,  A61K47/02 ,  A61K9/00 ,  A61K47/18 ,  A61K9/19 ,  A61K47/42 ,  A61K47/12 ,  A61K9/08

Abstract: The present invention provides stable pharmaceutical compositions of pegylated carfilzomib compounds, methods for preparing the compositions, and uses of the compositions for treating cancer, including hematologic malignancies such as multiple myeloma. The compositions can be stored in frozen form or lyophilized to dry solid form.

公开(公告)号：US20210163531A1

公开(公告)日：2021-06-03

申请号：US17046662

申请日：2019-03-28

Applicant: AMGEN INC.

Inventor： William Callahan ,  Lorenzo Desantiago ,  Clea Talley ,  Yael Wexler-Cohen ,  Jeffrey Abel ,  Rahul Kaushik ,  Nitya Mariam Jacob ,  Carson Tran ,  Nicole Ball ,  Monica Goss

IPC: C07K1/36 ,  C07K1/34 ,  C07K1/18 ,  C07K1/16 ,  C07K16/28 ,  C07K16/30 ,  C07K14/535 ,  C07K14/505 ,  C07K14/71 ,  C07K14/715 ,  C07K16/40 ,  C07K16/32 ,  C07K16/22 ,  C07K16/18

Abstract: The invention relates to methods for preparing stable buffered and buffer-free protein compositions. The invention also relates to methods of purifying proteins from one or more impurities.