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公开(公告)号：US20180305465A1
公开(公告)日：2018-10-25
申请号：US15779325
申请日：2016-11-23
Applicant: AMGEN INC. , XENCOR, INC.
Inventor： Jennitte Leann Stevens , Mercedesz Balazs , Olivier Nolan-Stevaux , Gregory Moore , John Desjarlais , Matthew J. Bernett , Seung Y. Chu , Rumana Rashid , Umesh Muchhal
CPC classification number: C07K16/468 , A61K2039/505 , A61P35/00 , C07K16/2809 , C07K16/40 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2317/92
Abstract: The present invention is directed to heterodimeric antibodies that bind CD3 and CD38.
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公开(公告)号：US20250092108A1
公开(公告)日：2025-03-20
申请号：US18628181
申请日：2024-04-05
Applicant: Xencor, Inc.
Inventor： Matthew Bernett , John Desjarlais , Rajat Varma , Rumana Rashid
IPC: C07K14/55 , A61K38/00 , C07K14/735 , C12N15/85
Abstract: The present invention provides IL-2-Fc fusion proteins comprising IL-2 variants.
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公开(公告)号：US20250011440A1
公开(公告)日：2025-01-09
申请号：US18885442
申请日：2024-09-13
Applicant: Xencor, Inc.
Inventor： Aaron Keith Chamberlain , Bassil Dahiyat , John Desjarlais , Sher Bahadur Karki , Gregory Lazar
Abstract: The present application relates to optimized IgG immunoglobulin variants, engineering methods for their generation, and their application, particularly for therapeutic purposes.
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公开(公告)号：US11932675B2
公开(公告)日：2024-03-19
申请号：US17067508
申请日：2020-10-09
Applicant: Genentech, Inc. , Xencor, Inc.
Inventor： John Desjarlais , Matthew Bernett , Michael Hedvat , Rajat Varma , Suzanne Schubbert , Christine Bonzon , Rumana Rashid , Juan Diaz , Patrick Holder , Christine Huang
CPC classification number: C07K14/5443 , A61P35/00 , C07K16/2818 , A61K38/00 , C07K2319/30
Abstract: The present invention relates to fusion proteins comprising variant IL-15 proteins, fusion proteins comprising variant anti-PD-1 antigen binding domains, and fusion proteins comprising variant IL-15 proteins and variant anti-PD-1 antigen binding domains. The present invention also relates to nucleic acid molecules, expression vectors, host cells and methods for making such fusion proteins and the use of such fusion proteins in the treatment of cancer.
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5.发明公开公开(公告)号：US20240026002A1
公开(公告)日：2024-01-25
申请号：US18452395
申请日：2023-08-18
Applicant: Xencor, Inc.
Inventor： Matthew J. Bernett , Gregory Moore , John Desjarlais , Michael Hedvat , Christine Bonzon
CPC classification number: C07K16/2818 , A61P35/00 , A61P37/06 , C07K16/2803 , C07K16/2827 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/52 , C07K2317/33 , C07K2317/31 , A61K2039/507
Abstract: The present invention is directed to bispecific, heterodimeric immunomodulatory antibodies.
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Patent Agency Ranking
公开(公告)号：US20230220081A1
公开(公告)日：2023-07-13
申请号：US18065462
申请日：2022-12-13
Applicant: Xencor, Inc.
Inventor： Matthew Bernett , Rumana Rashid , John Desjarlais , Rajat Varma , Christine Bonzon
CPC classification number: C07K16/2818 , C07K14/5443 , C07K14/7155 , C12N15/63 , A61P35/00 , C07K2317/24 , C07K2317/524 , A61K2039/505 , C07K2317/94 , C07K2319/30 , C07K2317/73 , C07K2317/526 , C07K2317/35 , C07K2317/92 , C07K2317/31 , C07K2317/53 , C07K2317/565 , C07K2317/55 , C07K2317/622 , C07K2317/74 , A61K38/00 , C07K2319/32
Abstract: The present invention is directed to novel bispecific heterodimeric Fc fusion proteins comprising an IL-15/IL-15Rα Fc-fusion protein and a PD-1 antibody fragment-Fc fusion protein.
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公开(公告)号：US20220380462A1
公开(公告)日：2022-12-01
申请号：US17339774
申请日：2021-06-04
Applicant: Xencor, Inc.
Inventor： Gregory Moore , Matthew Bernett , Rumana Rashid , John Desjarlais
IPC: C07K16/28
Abstract: The present invention is directed to optimized anti-CD3 variable sequences for use in a variety of bispecific formats, including those that utilize scFv components. The invention further relates to nucleic acids encoding for the polypeptide, to vectors comprising the same and to host cells comprising the vector. In another aspect, the invention provides for a pharmaceutical composition comprising the mentioned polypeptide and medical uses of the polypeptide.
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公开(公告)号：US11319355B2
公开(公告)日：2022-05-03
申请号：US16206849
申请日：2018-11-30
Applicant: Xencor, Inc.
Inventor： Matthew Bernett , John Desjarlais , Rajat Varma , Rumana Rashid
IPC: C07K14/55 , C07K14/735 , C12N15/85 , A61K38/00
Abstract: The present invention provides IL-2-Fc fusion proteins comprising IL-2 variants.
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公开(公告)号：US11225528B2
公开(公告)日：2022-01-18
申请号：US16354058
申请日：2019-03-14
Applicant: Xencor, Inc.
Inventor： Matthew J. Bernett , Gregory Moore , John Desjarlais , Seung Chu , Rumana Rashid , Umesh Muchhal , Sung-Hyung Lee
Abstract: The present invention is directed to novel heterodimeric antibodies.
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公开(公告)号：US11111315B2
公开(公告)日：2021-09-07
申请号：US15945681
申请日：2018-04-04
Applicant: Xencor, Inc.
Inventor： Matthew J. Bernett , Gregory Moore , John Desjarlais , Seung Chu , Rumana Rashid , Umesh Muchhal , Sung-Hyung Lee
Abstract: The present invention is directed to novel heterodimeric antibodies.
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