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公开(公告)号：US20180305465A1
公开(公告)日：2018-10-25
申请号：US15779325
申请日：2016-11-23
申请人： AMGEN INC. , XENCOR, INC.
发明人： Jennitte Leann Stevens , Mercedesz Balazs , Olivier Nolan-Stevaux , Gregory Moore , John Desjarlais , Matthew J. Bernett , Seung Y. Chu , Rumana Rashid , Umesh Muchhal
CPC分类号： C07K16/468 , A61K2039/505 , A61P35/00 , C07K16/2809 , C07K16/40 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2317/92
摘要： The present invention is directed to heterodimeric antibodies that bind CD3 and CD38.
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公开(公告)号：US09617348B2
公开(公告)日：2017-04-11
申请号：US13860500
申请日：2013-04-10
申请人： Xencor, Inc.
IPC分类号： A61K39/395 , C07K16/42 , C07K16/46
CPC分类号： C07K16/4291 , A61K2039/505 , A61P37/08 , C07K16/464 , C07K2317/24 , C07K2317/52 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to immunoglobulins that bind IgE and FcγRIIb with high affinity, said compositions being capable of inhibiting cells that express membrane-anchored IgE. Such compositions are useful for treating IgE-mediated disorders, including allergies and asthma.
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公开(公告)号：US09540451B2
公开(公告)日：2017-01-10
申请号：US13860484
申请日：2013-04-10
申请人： Xencor, Inc.
CPC分类号： C07K16/4291 , A61K2039/505 , A61P37/08 , C07K16/464 , C07K2317/24 , C07K2317/52 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to immunoglobulins that bind IgE and FcγRIIb with high affinity, said compositions being capable of inhibiting cells that express membrane-anchored IgE. Such compositions are useful for treating IgE-mediated disorders, including allergies and asthma.
摘要翻译： 本发明涉及以高亲和力结合IgE和FcγRIIb的免疫球蛋白，所述组合物能够抑制表达膜锚定的IgE的细胞。 这样的组合物可用于治疗IgE介导的病症，包括过敏和哮喘。
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公开(公告)号：US09266966B2
公开(公告)日：2016-02-23
申请号：US14510054
申请日：2014-10-08
申请人： Xencor, Inc.
IPC分类号： A61K39/395 , C07K16/42 , C07K16/46
CPC分类号： C07K16/4291 , A61K2039/505 , A61P37/08 , C07K16/464 , C07K2317/24 , C07K2317/52 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to immunoglobulins that bind IgE and FcγRIIb with high affinity, said compositions being capable of inhibiting cells that express membrane-anchored IgE. Such compositions are useful for treating IgE-mediated disorders, including allergies and asthma.
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公开(公告)号：US09221916B2
公开(公告)日：2015-12-29
申请号：US14510037
申请日：2014-10-08
申请人： Xencor, Inc.
IPC分类号： A61K39/395 , C07K16/42 , C07K16/46
CPC分类号： C07K16/4291 , A61K2039/505 , A61P37/08 , C07K16/464 , C07K2317/24 , C07K2317/52 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to immunoglobulins that bind IgE and FcγRIIb with high affinity, said compositions being capable of inhibiting cells that express membrane-anchored IgE. Such compositions are useful for treating IgE-mediated disorders, including allergies and asthma.
摘要翻译： 本发明涉及以高亲和力结合IgE和FcγRIIb的免疫球蛋白，所述组合物能够抑制表达膜锚定的IgE的细胞。 这样的组合物可用于治疗IgE介导的病症，包括过敏和哮喘。
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公开(公告)号：US11739144B2
公开(公告)日：2023-08-29
申请号：US17690702
申请日：2022-03-09
申请人： Xencor, Inc.
发明人： Matthew S. Faber , Sung-Hyung Lee , Yoon Kyung Kim , Jing Qi , Kendra N. Avery , Seung Y. Chu , Alex Nisthal , Matthew J. Bernett , John R. Desjarlais , Chad Borchert
CPC分类号： C07K16/28 , A61P35/00 , C07K16/2809 , C07K16/468 , C12N15/63
摘要： Provided herein are novel CLDN6 binding domains, and anti-CLDN6×anti-CD3 antibodies that include such CLDN6 binding domains. Also provided herein are methods of using such antibodies for the treatment of CLDN6-associated cancers.
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公开(公告)号：US11566080B2
公开(公告)日：2023-01-31
申请号：US16783032
申请日：2020-02-05
申请人： Xencor, Inc.
摘要： The present invention relates to immunoglobulins that bind IgE and FcγRIIb with high affinity, said compositions being capable of inhibiting cells that express membrane-anchored IgE. Such compositions are useful for treating IgE-mediated disorders, including allergies and asthma.
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公开(公告)号：US11352442B2
公开(公告)日：2022-06-07
申请号：US16660415
申请日：2019-10-22
申请人： XENCOR, INC.
发明人： Matthew J. Bernett , Gregory Moore , John Desjarlais , Seung Y. Chu , Rumana Rashid , Umesh Muchhal
摘要： The present invention is directed to heterodimeric antibodies that bind CD3 and CD38.
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公开(公告)号：US20180094079A1
公开(公告)日：2018-04-05
申请号：US15786252
申请日：2017-10-17
申请人： XENCOR, INC.
CPC分类号： C07K16/468 , C07K16/2809 , C07K16/2896 , C07K16/30 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要： The invention provides novel heterodimeric proteins including heterodimeric antibodies.
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公开(公告)号：US20240228608A9
公开(公告)日：2024-07-11
申请号：US18348244
申请日：2023-07-06
申请人： Xencor, Inc.
发明人： Matthew S. Faber , Sung-Hyung Lee , Yoon Kyung Kim , Jing Qi , Kendra N. Avery , Seung Y. Chu , Alex Nisthal , Matthew J. Bernett , John R. Desjarlais , Chad Borchert
CPC分类号： C07K16/28 , A61P35/00 , C07K16/2809 , C07K16/468 , C12N15/63
摘要： Provided herein are novel CLDN6 binding domains, and anti-CLDN6×anti-CD3 antibodies that include such CLDN6 binding domains. Also provided herein are methods of using such antibodies for the treatment of CLDN6-associated cancers.
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