公开(公告)号：US20200031766A1

公开(公告)日：2020-01-30

申请号：US16337729

申请日：2017-09-26

Applicant: AMOREPACIFIC CORPORATION

Inventor： Byoung Young WOO ,  Ki-Wha LEE ,  Jihae LEE ,  Chang Soon CHOI ,  Miyoung PARK ,  Young-Ho PARK ,  Sarva JAYAPRAKASH ,  Sridhar REGATI ,  Mamidi SRINIVAS ,  Krushnakant PATEL ,  M. RAMAMOHAN

IPC: C07C311/08 ,  C07C303/44 ,  B01D9/00

Abstract: Disclosed in the present specification is a method capable of preparing N-[4-[(1R)-1-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]ethyl]-2,6-difluorophenyl]-methanesulfonamide (INT028-2) with high optical purity, through the selection of Ellman-chiral auxiliaries and the re-crystallization and separation of optical isomers. According to the above method, high-purity N-[4-[(1R)-1-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]ethyl]-2,6-difluorophenyl]-methanesulfonamide with excellent quality can be produced at room temperature by improving cryogenic process conditions necessary for realizing high optical purity, and thus the trimming due to the process failure rate can be remarkably reduced.

公开(公告)号：US20230095813A1

公开(公告)日：2023-03-30

申请号：US17935949

申请日：2022-09-28

Applicant: AMOREPACIFIC CORPORATION

Inventor： Changyong MOON ,  Su Hwan KIM ,  Jihae LEE ,  Kyoungmi JUNG ,  Wonkyung CHO ,  Wanki KIM ,  Jong Hwa ROH ,  Chan WOONG PARK

IPC: A61K31/197 ,  A61K31/198 ,  A61K31/455 ,  A61P25/00 ,  A61K9/20 ,  A61K9/48 ,  A61K9/14 ,  A61K9/16 ,  A61K9/00 ,  A23L33/15 ,  A23L33/175

Abstract: The present disclosure relates to a composition for improving sleep quality, including γ-aminobutyric acid (GABA) or a salt, hydrate or solvate thereof; and at least one of arginine, niacin, and salts, hydrates and solvates thereof. The composition for improving sleep quality may improve the sleep quality by increasing melatonin secretion. In addition, in another aspect, the present disclosure provides a composition for alleviating stress, including γ-aminobutyric acid (GABA) or a salt, hydrate or solvate thereof; and at least one of arginine, niacin, and salts, hydrates and solvates thereof.