公开(公告)号：US20170342027A1

公开(公告)日：2017-11-30

申请号：US15325349

申请日：2016-02-15

Applicant: AMOREPACIFIC CORPORATION

Inventor： Byoung Young WOO ,  Ki-Wha LEE ,  Kwang-Hyun SHIN ,  Miyoung PARK ,  Kyoungmi JUNG ,  Joonho CHOI ,  Gyeyoung CHOI ,  Wonkyung CHO ,  Young-Ho PARK

IPC: C07C303/42 ,  C07C63/06 ,  C07B57/00 ,  C07C311/08 ,  C07C303/36

CPC classification number: C07C303/42 ,  C07B57/00 ,  C07B2200/07 ,  C07C63/06 ,  C07C303/36 ,  C07C303/44 ,  C07C311/08 ,  C07D213/56

Abstract: The present specification relates to a chiral resolution method of a stereoisomer mixture, comprising a step of mixing a stereoisomer mixture of compounds, in which an amine group is bound to an asymmetric carbon atom, with a chiral auxiliary and salt-forming auxiliary compound, wherein the chiral auxiliary is an O,O′-diacyltartaric acid derivative, more specifically, a 2,3-dibenzoyl-tartaric acid or O,O′-di-p-toluoyl tartaric acid, the salt-forming auxiliary compound is mandelic acid or camphorsulfonic acid, and an optical isomer having a high level of optical purity can be obtained by using the method. Therefore, according to one aspect of the present invention, the method can be useful in pharmaceutical or cosmetic field when preparing an optical isomer having a high optical purity.

公开(公告)号：US20200031766A1

公开(公告)日：2020-01-30

申请号：US16337729

申请日：2017-09-26

Applicant: AMOREPACIFIC CORPORATION

Inventor： Byoung Young WOO ,  Ki-Wha LEE ,  Jihae LEE ,  Chang Soon CHOI ,  Miyoung PARK ,  Young-Ho PARK ,  Sarva JAYAPRAKASH ,  Sridhar REGATI ,  Mamidi SRINIVAS ,  Krushnakant PATEL ,  M. RAMAMOHAN

IPC: C07C311/08 ,  C07C303/44 ,  B01D9/00

Abstract: Disclosed in the present specification is a method capable of preparing N-[4-[(1R)-1-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]ethyl]-2,6-difluorophenyl]-methanesulfonamide (INT028-2) with high optical purity, through the selection of Ellman-chiral auxiliaries and the re-crystallization and separation of optical isomers. According to the above method, high-purity N-[4-[(1R)-1-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]ethyl]-2,6-difluorophenyl]-methanesulfonamide with excellent quality can be produced at room temperature by improving cryogenic process conditions necessary for realizing high optical purity, and thus the trimming due to the process failure rate can be remarkably reduced.

公开(公告)号：US20220125709A1

公开(公告)日：2022-04-28

申请号：US17512381

申请日：2021-10-27

Applicant: AMOREPACIFIC CORPORATION

Inventor： Byoung Young WOO ,  Hyungmin KIM ,  Sejun PARK ,  Somi LEE ,  Yong Deog HONG

IPC: A61K8/9789 ,  A61Q19/00

Abstract: The present disclosure relates to a ginseng powder, a cosmetic composition containing the same and a method for preparing the same. The present disclosure provides a ginseng powder with superior dissolution rate of active ingredients even at relatively low temperature. Therefore, the present disclosure provides an effect that the active ingredients contained in ginseng can be utilized effectively.

公开(公告)号：US20170283347A1

公开(公告)日：2017-10-05

申请号：US15506972

申请日：2015-08-24

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup JOO ,  Song Seok SHIN ,  Byoung Young WOO ,  Heung Soo BAEK ,  Yong Deog HONG ,  Hong-Ju SHIN ,  Yeon Su JEONG ,  Jon Hwan LEE

IPC: C07C13/615 ,  C07C233/57 ,  C07C15/04

Abstract: Disclosed is a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. Also disclosed is a method for preparing a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. The novel adamantane derivative compound or the like has an excellent anti-androgenic effect.

公开(公告)号：US20220125692A1

公开(公告)日：2022-04-28

申请号：US17512347

申请日：2021-10-27

Applicant: AMOREPACIFIC CORPORATION

Inventor： Byoung Young WOO ,  Yong Deog HONG ,  Joonyoung HWANG

IPC: A61K8/06 ,  A61K8/9789 ,  A61K8/92

Abstract: The present disclosure relates to a nanoemulsion cosmetic composition including an oil phase and an aqueous phase, wherein the oil phase contains a ginseng nanopowder and an oil swollen by the ginseng nanopowder, the composition does not contain an additional surfactant, and the ginseng nanopowder is distributed uniformly in the composition. According to the present disclosure, there is provided a nanoemulsion cosmetic composition which contains a natural substance by containing a ginseng nanopowder and an oil swollen by the ginseng nanopowder in an oil phase and provides beneficial effect to skin.

公开(公告)号：US20220000775A1

公开(公告)日：2022-01-06

申请号：US17289382

申请日：2019-10-16

Applicant: Amorepacific Corporation

Inventor： Wonkyung CHO ,  Kwanghyun SHIN ,  Joonho CHOI ,  Kiwha LEE ,  Jong Hwa ROH ,  Miyoung PARK ,  Youngho PARK ,  Eunsil PARK ,  Jaehong PARK ,  Byoung Young WOO ,  Min Soo KIM ,  Eun Sol HA

IPC: A61K9/06 ,  A61K31/44 ,  A61K47/10 ,  A61K47/32 ,  A61K47/38 ,  A61K47/26

Abstract: One aspect of the present disclosure relates to a sol-gel composition enabling reversible sol-gel transition and, more specifically, to a sol-gel composition of which the viscosity changes by external physical force so that reversible sol-gel transition is performed.

公开(公告)号：US20200215040A1

公开(公告)日：2020-07-09

申请号：US16638038

申请日：2018-08-10

Applicant: AMOREPACIFIC CORPORATION

Inventor： Joon Ho CHOI ,  Won Kyung CHO ,  Kwang-Hyun SHIN ,  Byoung Young WOO ,  Ki-Wha LEE ,  Min-Soo KIM ,  Jong Hwa ROH ,  Mi Young PARK ,  Young-Ho PARK ,  Eun Sil PARK ,  Jae Hong PARK

IPC: A61K31/44 ,  A61K47/38 ,  A61K9/00

Abstract: One aspect of the present disclosure is a pharmaceutical composition which includes (R)—N-[1-(3,5-difluoro-4-methansulfonylamino-phenyl)-ethyl]-3-(2-propyl-6-trifluoromethyl-pyridin-3-yl)-acrylamide as a first component and a cellulosic polymer as a second component, wherein the composition of one aspect of the present disclosure has a formulation characteristic in which crystal formation is delayed for a long time.