公开(公告)号：US20200031766A1

公开(公告)日：2020-01-30

申请号：US16337729

申请日：2017-09-26

Applicant: AMOREPACIFIC CORPORATION

Inventor： Byoung Young WOO ,  Ki-Wha LEE ,  Jihae LEE ,  Chang Soon CHOI ,  Miyoung PARK ,  Young-Ho PARK ,  Sarva JAYAPRAKASH ,  Sridhar REGATI ,  Mamidi SRINIVAS ,  Krushnakant PATEL ,  M. RAMAMOHAN

IPC: C07C311/08 ,  C07C303/44 ,  B01D9/00

Abstract: Disclosed in the present specification is a method capable of preparing N-[4-[(1R)-1-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]ethyl]-2,6-difluorophenyl]-methanesulfonamide (INT028-2) with high optical purity, through the selection of Ellman-chiral auxiliaries and the re-crystallization and separation of optical isomers. According to the above method, high-purity N-[4-[(1R)-1-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]ethyl]-2,6-difluorophenyl]-methanesulfonamide with excellent quality can be produced at room temperature by improving cryogenic process conditions necessary for realizing high optical purity, and thus the trimming due to the process failure rate can be remarkably reduced.

公开(公告)号：US20240180993A1

公开(公告)日：2024-06-06

申请号：US18442847

申请日：2024-02-15

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyunjin NAM ,  Juewon KIM ,  Miyoung PARK ,  Kyoungmi JUNG ,  Jinoh CHUNG ,  Gyeyoung CHOI ,  Wanki KIM

IPC: A61K36/82 ,  A23L2/52 ,  A23L33/00 ,  A23L33/105 ,  A61K9/00 ,  A61K31/353 ,  A61P7/00 ,  A61P11/16

CPC classification number: A61K36/82 ,  A23L2/52 ,  A23L33/105 ,  A23L33/40 ,  A61K9/0056 ,  A61K31/353 ,  A61P7/00 ,  A61P11/16 ,  A23V2002/00 ,  A61K2236/33 ,  A61K2236/331 ,  A61K2236/333

Abstract: An aspect of the present disclosure relates to a composition for improving respiratory health exposed to particulate matter, which contains a green tea extract, a green tea polysaccharide and a green tea flavonol as active ingredients. The composition provided in an aspect of the present disclosure can improve respiratory health damaged by exposure to particulate matter by enhancing the effect of preventing adsorption of particulate matter to bronchial epithelial cells and activating the cilia of bronchial epithelial cells. The composition provided in an aspect of the present disclosure may decrease blood heavy metal level.

公开(公告)号：US20210379136A1

公开(公告)日：2021-12-09

申请号：US17341868

申请日：2021-06-08

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyunjin NAM ,  Juewon KIM ,  Miyoung PARK ,  Kyoungmi JUNG ,  Jinoh CHUNG ,  Gyeyoung CHOI ,  Wanki KIM

IPC: A61K36/82 ,  A61P11/16 ,  A61P7/00 ,  A61K31/353 ,  A61K9/00 ,  A23L33/00 ,  A23L33/105 ,  A23L2/52

Abstract: An aspect of the present disclosure relates to a composition for improving respiratory health exposed to particulate matter, which contains a green tea extract, a green tea polysaccharide and a green tea flavonol as active ingredients. The composition provided in an aspect of the present disclosure can improve respiratory health damaged by exposure to particulate matter by enhancing the effect of preventing adsorption of particulate matter to bronchial epithelial cells and activating the cilia of bronchial epithelial cells. The composition provided in an aspect of the present disclosure may decrease blood heavy metal level.

公开(公告)号：US20240091296A1

公开(公告)日：2024-03-21

申请号：US18520281

申请日：2023-11-27

Applicant: AMOREPACIFIC CORPORATION

Inventor： Juewon KIM ,  Si Young CHO ,  Hyungsu KIM ,  Wonseok PARK ,  Joonho CHOI ,  Dong Hyun KIM ,  Jaewon YOU ,  Miyoung PARK

IPC: A61K36/82 ,  A23L33/105 ,  A61K8/97 ,  A61Q19/02 ,  A61Q19/08

CPC classification number: A61K36/82 ,  A23L33/105 ,  A61K8/97 ,  A61Q19/02 ,  A61Q19/08 ,  A61K2800/782

Abstract: Disclosed is to provide a composition for skin-whitening or preventing or improving skin wrinkles, comprising a green tea extract which has modified amounts of ingredients. More specifically, the extract and composition according to one aspect of the present disclosure are derived from natural plants that cause less irritation to the skin and are eco-friendly, thus they are safe, and thereby the extract and composition can exhibit excellent effects of effectively inhibiting melanin production and tyrosinase activity and preventing or improving skin whitening, and can exhibit excellent effects of effectively inhibiting the expression of MMP-1 and preventing or improving skin wrinkles.

公开(公告)号：US20220000775A1

公开(公告)日：2022-01-06

申请号：US17289382

申请日：2019-10-16

Applicant: Amorepacific Corporation

Inventor： Wonkyung CHO ,  Kwanghyun SHIN ,  Joonho CHOI ,  Kiwha LEE ,  Jong Hwa ROH ,  Miyoung PARK ,  Youngho PARK ,  Eunsil PARK ,  Jaehong PARK ,  Byoung Young WOO ,  Min Soo KIM ,  Eun Sol HA

IPC: A61K9/06 ,  A61K31/44 ,  A61K47/10 ,  A61K47/32 ,  A61K47/38 ,  A61K47/26

Abstract: One aspect of the present disclosure relates to a sol-gel composition enabling reversible sol-gel transition and, more specifically, to a sol-gel composition of which the viscosity changes by external physical force so that reversible sol-gel transition is performed.

公开(公告)号：US20220218778A1

公开(公告)日：2022-07-14

申请号：US17570765

申请日：2022-01-07

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyun Woo JEONG ,  Si Young CHO ,  Yong Deog HONG ,  Wanki KIM ,  Miyoung PARK

IPC: A61K36/82 ,  A61K31/352 ,  A61K9/20 ,  A61K9/16 ,  A61K9/00 ,  A61P3/04

Abstract: The present disclosure relates to a composition for reducing body fat, which contains a green tea extract containing 4 wt % or more of gallocatechin gallate based on the total weight of the extract as an active ingredient, and a method for preparing the same. The composition according to the present disclosure provides a superior effect of reducing body fat as the green tea extract containing gallocatechin gallate is contained as an active ingredient. Accordingly, it can provide substances effective for treating obesity through various researches.

公开(公告)号：US20200222488A1

公开(公告)日：2020-07-16

申请号：US16742812

申请日：2020-01-14

Applicant: AMOREPACIFIC CORPORATION

Inventor： Juewon KIM ,  Si Young CHO ,  Hyungsu KIM ,  Wonseok PARK ,  Joonho CHOI ,  Dong Hyun KIM ,  Jaewon YOU ,  Miyoung PARK

IPC: A61K36/82 ,  A23L33/105 ,  A61Q19/08 ,  A61K8/97 ,  A61Q19/02

Abstract: Disclosed is to provide a composition for skin-whitening or preventing or improving skin wrinkles, comprising a green tea extract which has modified amounts of ingredients. More specifically, the extract and composition according to one aspect of the present disclosure are derived from natural plants that cause less irritation to the skin and are eco-friendly, thus they are safe, and thereby the extract and composition can exhibit excellent effects of effectively inhibiting melanin production and tyrosinase activity and preventing or improving skin whitening, and can exhibit excellent effects of effectively inhibiting the expression of MMP-1 and preventing or improving skin wrinkles.

公开(公告)号：US20170342027A1

公开(公告)日：2017-11-30

申请号：US15325349

申请日：2016-02-15

Applicant: AMOREPACIFIC CORPORATION

Inventor： Byoung Young WOO ,  Ki-Wha LEE ,  Kwang-Hyun SHIN ,  Miyoung PARK ,  Kyoungmi JUNG ,  Joonho CHOI ,  Gyeyoung CHOI ,  Wonkyung CHO ,  Young-Ho PARK

IPC: C07C303/42 ,  C07C63/06 ,  C07B57/00 ,  C07C311/08 ,  C07C303/36

CPC classification number: C07C303/42 ,  C07B57/00 ,  C07B2200/07 ,  C07C63/06 ,  C07C303/36 ,  C07C303/44 ,  C07C311/08 ,  C07D213/56

Abstract: The present specification relates to a chiral resolution method of a stereoisomer mixture, comprising a step of mixing a stereoisomer mixture of compounds, in which an amine group is bound to an asymmetric carbon atom, with a chiral auxiliary and salt-forming auxiliary compound, wherein the chiral auxiliary is an O,O′-diacyltartaric acid derivative, more specifically, a 2,3-dibenzoyl-tartaric acid or O,O′-di-p-toluoyl tartaric acid, the salt-forming auxiliary compound is mandelic acid or camphorsulfonic acid, and an optical isomer having a high level of optical purity can be obtained by using the method. Therefore, according to one aspect of the present invention, the method can be useful in pharmaceutical or cosmetic field when preparing an optical isomer having a high optical purity.