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公开(公告)号：US20220033392A1
公开(公告)日：2022-02-03
申请号：US17226531
申请日：2021-04-09
发明人： Nicholas E. Bencivenga , David C. Dalgarno , Joseph M. Gozgit , Wei-Sheng Huang , Anna Kohlmann , Feng Li , Jiwei Qi , William C. Shakespeare , Ranny M. Thomas , Yihan Wang , Xiaotian Zhu
IPC分类号： C07D417/12 , C07D417/04 , C07D277/46
摘要： The invention relates to c-Kit inhibitors useful in the treatment of cancers, and other serine-threonine kinase mediated diseases, having the Formula: wherein A, L, R1, R2, R3, and n are described herein.
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公开(公告)号：US20170253594A1
公开(公告)日：2017-09-07
申请号：US15600023
申请日：2017-05-19
发明人： Wei-Sheng Huang , Yongjin Gong , Feng Li , Nicholas E. Bencivenga , David C. Delgamo , Anna Kohlmann , William C. Shakespeare , Ranny M. Thomas , Xiaotian Zhu , Angela V. West , Willmen Youngsaye , Yun Zhang , Tianjun Zhou
IPC分类号： C07D471/04 , C07D403/04 , C07D401/14 , C07D405/12 , C07F9/6558
CPC分类号： C07D471/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14 , C07F9/65583
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.
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公开(公告)号：US11117883B2
公开(公告)日：2021-09-14
申请号：US16469535
申请日：2017-12-14
发明人： Nicholas E. Bencivenga , David C. Dalgarno , Joseph M. Gozgit , Wei-Sheng Huang , Anna Kohlmann , Feng Li , Jiwei Qi , William C. Shakespeare , Ranny M. Thomas , Yihan Wang , Yun Zhang , Xiaotian Zhu
IPC分类号： A61K31/4184 , A61K31/4178 , A61K31/4439 , A61K31/4427 , C07D403/14 , C07D403/12 , C07D403/04 , C07D401/14 , C07D401/12 , C07D413/14 , C07D405/14
摘要： The invention relates to c-Kit inhibitors useful in the treatment of cancers, and other serine-threonine kinase mediated diseases, having the Formula: (I) where A, L, R1, R2, R3, and n are described herein.
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公开(公告)号：US11001580B2
公开(公告)日：2021-05-11
申请号：US16469517
申请日：2017-12-14
发明人： Nicholas E. Bencivenga , David C. Dalgarno , Joseph M. Gozgit , Wei-Sheng Huang , Anna Kohlmann , Feng Li , Jiwei Qi , William C. Shakespeare , Ranny M. Thomas , Yihan Wang , Xiaotian Zhu
IPC分类号： C07D417/14 , C07D417/12
摘要： The invention relates to c-Kit inhibitors useful in the treatment of cancers, and other-threonine kinase mediated diseases, having the Formula: (I) wherein A, L, R1, R2, R3, and n are described herein.
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公开(公告)号：US20190218212A1
公开(公告)日：2019-07-18
申请号：US16257577
申请日：2019-01-25
发明人： Wei-Sheng Huang , Yongjin Gong , Feng Li , Nicholas E. Bencivenga , David C. Dalgarno , Anna Kohlmann , William C. Shakespeare , Ranny M. Thomas , Xiaotian Zhu , Angela V. West , Willmen Youngsaye , Yun Zhang , Tianjun Zhou
IPC分类号： C07D471/04 , C07F9/6558 , C07D405/12 , C07D403/04 , C07D403/14 , C07D405/14 , C07D401/14 , C07D401/04
CPC分类号： C07D471/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14 , C07F9/65583
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.
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公开(公告)号：US09573934B2
公开(公告)日：2017-02-21
申请号：US14607831
申请日：2015-01-28
发明人： Feng Li , Yihan Wang
IPC分类号： C07D211/60 , C07C51/06 , C07C209/08 , C07C231/02 , C07C235/34 , C07D205/04 , C07D319/06 , C07D401/12 , C07D319/04 , C07B53/00 , C07C209/62 , C07C209/74 , C07C231/18
CPC分类号： C07D401/12 , C07B53/00 , C07B2200/07 , C07C51/06 , C07C209/08 , C07C209/62 , C07C209/74 , C07C231/02 , C07C231/18 , C07C235/34 , C07D205/04 , C07D211/60 , C07D319/04 , C07D319/06 , C07C211/15 , C07C211/13 , C07C235/20 , C07C59/64
摘要： The invention features methods and compositions for the synthesis of multimerizing agents.
摘要翻译： 本发明的特征在于用于合成多聚化剂的方法和组合物。
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公开(公告)号：US20150148543A1
公开(公告)日：2015-05-28
申请号：US14607831
申请日：2015-01-28
发明人： Feng Li , Yihan Wang
IPC分类号： C07D401/12 , C07D205/04 , C07C231/02 , C07C51/06 , C07C209/08 , C07D319/06 , C07C235/34
CPC分类号： C07D401/12 , C07B53/00 , C07B2200/07 , C07C51/06 , C07C209/08 , C07C209/62 , C07C209/74 , C07C231/02 , C07C231/18 , C07C235/34 , C07D205/04 , C07D211/60 , C07D319/04 , C07D319/06 , C07C211/15 , C07C211/13 , C07C235/20 , C07C59/64
摘要： The invention features methods and compositions for the synthesis of multimerizing agents.
摘要翻译： 本发明的特征在于用于合成多聚化剂的方法和组合物。
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公开(公告)号：US11753404B2
公开(公告)日：2023-09-12
申请号：US17226531
申请日：2021-04-09
发明人： Nicholas E. Bencivenga , David C. Dalgarno , Joseph M. Gozgit , Wei-Sheng Huang , Anna Kohlmann , Feng Li , Jiwei Qi , William C. Shakespeare , Ranny M. Thomas , Yihan Wang , Xiaotian Zhu
IPC分类号： C07D417/14 , C07D417/12 , C07D277/46 , C07D417/04
CPC分类号： C07D417/14 , C07D277/46 , C07D417/04 , C07D417/12
摘要： The invention relates to c-Kit inhibitors useful in the treatment of cancers, and other serine-threonine kinase mediated diseases, having the Formula:
wherein A, L, R1, R2, R3, and n are described herein.-
公开(公告)号：US10227342B2
公开(公告)日：2019-03-12
申请号：US15319637
申请日：2015-05-13
发明人： Wei-Sheng Huang , Yongjin Gong , Feng Li , Nicholas E. Bencivenga , David C. Dalgarno , Anna Kohlmann , William C. Shakespeare , Ranny M. Thomas , Xiaotian Zhu , Angela West , Willmen Youngsaye , Yun Zhang , Tianjun Zhou
IPC分类号： C07D403/14 , A61K31/506 , C07D471/04 , C07D405/12 , C07D403/04 , C07D401/14 , C07F9/6558
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.
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公开(公告)号：US09834521B2
公开(公告)日：2017-12-05
申请号：US14774359
申请日：2014-03-13
发明人： Stephan G. Zech , Anna Kohlmann , Feng Li , Yihan Wang , Tianjun Zhou , David C. Dalgarno , William C. Shakespeare , Xiaotian Zhu
IPC分类号： C07D243/08 , A61K31/551 , C07D401/10 , C07D403/10 , C07D417/10 , C07D245/02 , C07D401/14 , C07D403/14 , C07D413/10 , C07D413/14 , C07F9/645
CPC分类号： C07D243/08 , A61K31/551 , C07D245/02 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07F9/645
摘要： This invention relates to compounds of the general formula (I): in which the variable groups are as identified herein, and to preparation and use of the compounds.
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