公开(公告)号：US11918826B2

公开(公告)日：2024-03-05

申请号：US17225711

申请日：2021-04-08

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Joseph T. Smith ,  Michael Goryll ,  Dixie Kullman ,  Jitendran Muthuswamy ,  Jennifer Blain Christen

IPC: A61N5/06

CPC classification number: A61N5/0622 ,  A61N5/0618 ,  A61N2005/0626 ,  A61N2005/0652 ,  A61N2005/0653 ,  A61N2005/0663

Abstract: A system and method for modulating optogenetic vagus neurons in a noninvasive and transcutaneous manner is disclosed. The system and method comprises a two-dimensional array of organic light emitting diodes (OLEDs), a voltage-generating unit, a control unit, and a feedback loop. The array is placed on a subject's outer ear. Because the array is flexible, it can be closely placed on the skin of the outer ear. The array can deliver optical therapy and monitor heart rate variability (HRV) of the subject simultaneously, and the pixels of the array can be individually addressed. The voltage-generating unit generates pulsed voltage to the OLEDs. The control unit is connected to the array and controls the array and therapeutic patterns. The feedback loop uses the HRV to identify the therapeutic patterns.

公开(公告)号：US20210220668A1

公开(公告)日：2021-07-22

申请号：US17225711

申请日：2021-04-08

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Joseph T. Smith ,  Michael Goryll ,  Dixie Kullman ,  Jitendran Muthuswamy ,  Jennifer Blain Christen

IPC: A61N5/06

Abstract: A system and method for modulating optogenetic vagus neurons in a noninvasive and transcutaneous manner is disclosed. The system and method comprises a two-dimensional array of organic light emitting diodes (OLEDs), a voltage-generating unit, a control unit, and a feedback loop. The array is placed on a subject's outer ear. Because the array is flexible, it can be closely placed on the skin of the outer ear. The array can deliver optical therapy and monitor heart rate variability (HRV) of the subject simultaneously, and the pixels of the array can be individually addressed. The voltage-generating unit generates pulsed voltage to the OLEDs. The control unit is connected to the array and controls the array and therapeutic patterns. The feedback loop uses the HRV to identify the therapeutic patterns.

公开(公告)号：US20160287898A1

公开(公告)日：2016-10-06

申请号：US15086800

申请日：2016-03-31

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Joseph T. Smith ,  Michael Goryll ,  Dixie Kullman ,  Jitendran Muthuswamy ,  Jennifer Blain Christen

IPC: A61N5/06

CPC classification number: A61N5/0622 ,  A61N5/0618 ,  A61N2005/0626 ,  A61N2005/0652 ,  A61N2005/0653 ,  A61N2005/0663

Abstract: A system and method for modulating optogenetic vagus neurons in a noninvasive and transcutaneous manner is disclosed. The system and method comprises a two-dimensional array of organic light emitting diodes (OLEDs), a voltage-generating unit, a control unit, and a feedback loop. The array is placed on a subject's outer ear. Because the array is flexible, it can be closely placed on the skin of the outer ear. The array can deliver optical therapy and monitor heart rate variability (HRV) of the subject simultaneously, and the pixels of the array can be individually addressed. The voltage-generating unit generates pulsed voltage to the OLEDs. The control unit is connected to the array and controls the array and therapeutic patterns. The feedback loop uses the HRV to identify the therapeutic patterns.

Abstract translation: 公开了一种用于以非侵入性和经皮方式调节视神经迷走神经元的系统和方法。 该系统和方法包括有机发光二极管（OLED），电压产生单元，控制单元和反馈回路的二维阵列。 将阵列放置在受试者的外耳上。 因为阵列是灵活的，它可以紧密地放置在外耳的皮肤上。 阵列可以同时提供光学治疗和监测受试者的心率变异性（HRV），阵列的像素可以单独寻址。 电压产生单元向OLED产生脉冲电压。 控制单元连接到阵列并控制阵列和治疗方式。 反馈回路使用HRV来识别治疗模式。

公开(公告)号：US10974065B2

公开(公告)日：2021-04-13

申请号：US15086800

申请日：2016-03-31

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Joseph T. Smith ,  Michael Goryll ,  Dixie Kullman ,  Jitendran Muthuswamy ,  Jennifer Blain Christen

IPC: A61N5/06

Abstract: A system and method for modulating optogenetic vagus neurons in a noninvasive and transcutaneous manner is disclosed. The system and method comprises a two-dimensional array of organic light emitting diodes (OLEDs), a voltage-generating unit, a control unit, and a feedback loop. The array is placed on a subject's outer ear. Because the array is flexible, it can be closely placed on the skin of the outer ear. The array can deliver optical therapy and monitor heart rate variability (HRV) of the subject simultaneously, and the pixels of the array can be individually addressed. The voltage-generating unit generates pulsed voltage to the OLEDs. The control unit is connected to the array and controls the array and therapeutic patterns. The feedback loop uses the HRV to identify the therapeutic patterns.

公开(公告)号：US10589124B2

公开(公告)日：2020-03-17

申请号：US15111952

申请日：2015-01-13

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Joseph Smith ,  Barry O'Brien ,  Yong-Kyun Lee ,  Edward Bawolek ,  Jennifer Blain Christen ,  Michael Goryll ,  Jitendran Muthuswamy ,  George R. Kunnen ,  David Allee

IPC: A61N5/06 ,  A61B5/04

Abstract: Systems and methods for stimulating neural tissue are disclosed. An array of optically emissive pixels is configured to deliver light to the neural tissue of a subject. Individual pixels within the array can be addressed to selectively illuminate a portion of the neural tissue when a neurological event occurs. The system can also include an array of microelectrodes in electrical communication with the array of pixels and a power source. A biocompatible substrate can be used to support the microelectrodes pixels, and the power source. A microelectrode circuit and a pixel circuit can also be supported by the biocompatible substrate.

公开(公告)号：US20160345846A1

公开(公告)日：2016-12-01

申请号：US15161481

申请日：2016-05-23

Applicant: Arizona Board of Regents on Behalf of Arizona State University

Inventor： Joseph T. Smith ,  Edward J. Bawolek ,  Michael Goryll

IPC: A61B5/024 ,  H01L27/32 ,  H05B33/08

CPC classification number: A61B5/02427 ,  A61B5/02416 ,  A61B2562/0238 ,  A61B2562/046 ,  A61B2562/12 ,  A61B2562/164 ,  H01L27/3227 ,  H01L2227/326 ,  H01L2251/5338 ,  H05B33/0896

Abstract: A wearable biomedical device manufactured with a flat-panel display technology is provided. The device comprises flexible thin-film layers and a flexible substrate. The layers are laid on the substrate and contain a flexible two-dimensional array of organic light emitting diodes (OLEDs) and photodiodes. This array is connected to an external controller wirelessly or by wire, and the controller controls the pattern of activated OLEDs and photodiodes.

Abstract translation: 提供了一种使用平板显示技术制造的可佩戴的生物医学装置。 该装置包括柔性薄膜层和柔性基底。 这些层铺设在基板上并且包含有机发光二极管（OLED）和光电二极管的柔性二维阵列。 该阵列通过无线或有线连接到外部控制器，并且控制器控制激活的OLED和光电二极管的图案。