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公开(公告)号：US10532109B2
公开(公告)日：2020-01-14
申请号：US16301888
申请日：2017-05-08
Inventor： Shengxi Chen , Yanmin Zhang , Sidney Hecht
Abstract: Provided herein are therapeutic agents having specificity for having inhibitory activity against cancer cells that overexpress human epidermal growth factor receptor (HER) genes, including therapeutic agents comprising one or more HER-targeting peptides, pharmaceutical compositions comprising such therapeutic agents, and methods of using such compositions to treat or prevent a cancer or other disease condition associated with HER overexpression.
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公开(公告)号：US20190106396A1
公开(公告)日：2019-04-11
申请号：US16155525
申请日：2018-10-09
Inventor： Shengxi Chen
IPC: C07D295/30 , C07D211/98 , A61P35/00
CPC classification number: C07D295/30 , A61P35/00 , C07D211/98
Abstract: A series of double-component, bis O2-aryl diazeniumdiolate derivatives are provided, of which each molecule can release up to four nitric oxide molecules. These compounds show cytotoxic activities to cancer cells, such as human leukemia, breast cancer and lung cancer. Among them, the compound 3 showed the highest specific activity against human leukemia cells.
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3.发明授权公开(公告)号：US11529257B2
公开(公告)日：2022-12-20
申请号：US17092855
申请日：2020-11-09
Inventor： Shengxi Chen
IPC: A61F5/41 , A61F6/04 , A61K31/7056 , A61K33/00 , A61K9/00 , B32B27/04 , C08K3/20 , B32B27/40 , A61K9/70
Abstract: A condom apparatus including at least one of a condom containing a compound of Formula 1 wherein the condom is configured to deliver one or more active ingredients selected from the group consisting of arginine, a vasodilator, nitrates, an ergot alkaloid, a long acting alpha-adrenoceptor blocker, a short acting alpha-adrenoceptor blocker, an anti-hypertensive, a prostaglandin, and a phosphodiesterase inhibitor is disclosed.
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Patent Agency Ranking
4.发明授权公开(公告)号：US11534333B2
公开(公告)日：2022-12-27
申请号：US17090543
申请日：2020-11-05
Inventor： Shengxi Chen
IPC: A61F5/41 , A61F6/04 , A61K31/7056 , A61K33/00 , A61K9/00 , B32B27/04 , C08K3/20 , B32B27/40 , A61K9/70
Abstract: A method to enhance a male erection or female arousal in a mammal includes topically administering a compound of Formula 1 to the mammal.
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5.发明申请公开(公告)号：US20220265838A1
公开(公告)日：2022-08-25
申请号：US17630994
申请日：2020-07-22
Inventor： Sidney Hecht , Shengxi Chen
Abstract: Provided herein are therapeutic agents having specificity for having inhibitory activity against cancer cells that overexpress human epidermal growth factor receptor (HER) genes, including therapeutic agents comprising one or more HER-targeting peptides, pharmaceutical compositions comprising such therapeutic agents, and methods of using such compositions to treat or prevent a cancer or other disease condition associated with HER overexpression.
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公开(公告)号：US20210403983A1
公开(公告)日：2021-12-30
申请号：US17370859
申请日：2021-07-08
Inventor： Shengxi Chen , Sidney Hecht , Mingxuan Gao
IPC: C12Q1/6806 , C12Q1/70 , C12Q1/686 , C12Q1/6818 , C12Q1/682
Abstract: Described herein are compositions that may be used to detect viral nucleic acid. For example, these compositions may comprise a DNA-nanostructure, a capture oligonucleotide and a protector oligonucleotide, wherein the components are designed based on a duo-toehold-mediated displacement reaction (duo-TMDR) strategy. In this strategy, a first TMDR can switch off a Faster resonance energy transfer (FRET) process and a second TMDR can release the target viral nucleic acid and amplify the signal. Methods of using such compositions are also provided herein.
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公开(公告)号：US10556875B2
公开(公告)日：2020-02-11
申请号：US16155525
申请日：2018-10-09
Inventor： Shengxi Chen
IPC: A61K31/496 , C07D295/30 , C07D211/98 , A61P35/00
Abstract: A series of double-component, bis O2-aryl diazeniumdiolate derivatives are provided, of which each molecule can release up to four nitric oxide molecules. These compounds show cytotoxic activities to cancer cells, such as human leukemia, breast cancer and lung cancer. Among them, the compound 3 showed the highest specific activity against human leukemia cells.
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公开(公告)号：US20180371526A1
公开(公告)日：2018-12-27
申请号：US16016086
申请日：2018-06-22
Inventor： Shengxi Chen , Sidney Hecht , Mingxuan Gao
IPC: C12Q1/6806 , C12Q1/686 , C12Q1/70
Abstract: Described herein are compositions that may be used to detect viral nucleic acid. For example, these compositions may comprise a DNA-nanostructure, a capture oligonucleotide and a protector oligonucleotide, wherein the components are designed based on a duo-toehold-mediated displacement reaction (duo-TMDR) strategy. In this strategy, a first TMDR can switch off a Foster resonance energy transfer (FRET) process and a second TMDR can release the target viral nucleic acid and amplify the signal. Methods of using such compositions are also provided herein.
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