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公开(公告)号：US20220362375A1
公开(公告)日：2022-11-17
申请号：US17743058
申请日：2022-05-12
Inventor： Yung Chang , Sidney Hecht , Joseph Leal , Viswanath Arutla , Xiaowei Liu , Sriram Sokalingam
IPC: A61K39/385 , C07D401/14 , G16B15/00 , G16B20/00 , A61K47/64 , G01N33/94 , A61K39/00 , G16B15/30 , G16B20/30
Abstract: Provided herein are methods for rational design of nicotine haptens. More particularly, provided herein are methods for designing, selecting, and synthesizing nicotine haptens and nicotine hapten conjugates. Also provided herein are novel nicotine haptens and methods for using nicotine haptens to treat nicotine addiction.
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公开(公告)号：US10745366B2
公开(公告)日：2020-08-18
申请号：US16327284
申请日：2017-08-24
Inventor： Sidney Hecht , Omar Khdour , Sandipan Roy Chowdhury , Nishant P Visavadiya
IPC: C07D279/18 , A61K31/5415 , A61P39/06 , C07D279/14 , A61P25/28 , A61P9/00 , A61P3/10 , A61P35/00
Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3, R4, subscipt m and n, have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US10364227B2
公开(公告)日：2019-07-30
申请号：US15550273
申请日：2016-02-17
Inventor： Sidney Hecht , Omar Khdour , Mohammad Alam , Sriloy Dey , Yana Chen , Arnaud Chevalier
IPC: A61P3/04 , A61P9/00 , A61P9/04 , A61P9/10 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/28 , A61P35/00 , C07D239/47 , C07D239/52 , C07D401/04 , C07D403/04
Abstract: Compounds of formula (I) and salts are disclosed. Also disclosed are isotopes of compounds of formula I of the salts thereof. Pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using a compound of formula I are disclosed.
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公开(公告)号：US20160375131A1
公开(公告)日：2016-12-29
申请号：US15189930
申请日：2016-06-22
Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Yung Chang , Sidney Hecht , Joseph Leal , Viswanath Arutla , Xiaowei Liu , Sriram Sokalingam , Paul Pentel
IPC: A61K39/385 , G01N33/94 , G06F19/16 , G06F19/18 , C07D401/14 , A61K47/48
CPC classification number: A61K39/385 , A61K39/0013 , A61K47/646 , A61K2039/6012 , C07D401/14 , G01N33/946 , G06F19/16 , G06F19/18
Abstract: Provided herein are methods for rational design of nicotine haptens. More particularly, provided herein are methods for designing, selecting, and synthesizing nicotine haptens and nicotine hapten conjugates. Also provided herein are novel nicotine haptens and methods for using nicotine haptens to treat nicotine addiction.
Abstract translation: 本文提供了尼古丁半抗原合理设计的方法。 更具体地，本文提供了用于设计，选择和合成尼古丁半抗原和尼古丁半抗原共轭物的方法。 本文还提供了新型尼古丁半抗原以及使用尼古丁半抗原来治疗尼古丁成瘾的方法。
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公开(公告)号：US11560360B2
公开(公告)日：2023-01-24
申请号：US16924763
申请日：2020-07-09
Inventor： Sidney Hecht , Omar Khdour , Sandipan Roy Chowdhury , Nishant P. Visavadiya
IPC: C07D279/18 , C07D279/14 , A61P39/06 , A61P35/00 , A61P3/10 , A61P9/00 , A61P25/28 , A61K31/5415
Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3, R4, subscript m and n, have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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Patent Agency Ranking
公开(公告)号：US09957214B2
公开(公告)日：2018-05-01
申请号：US14434725
申请日：2013-10-10
Inventor： Manikandadas Mathilakathu Madathil , Omar Khdour , Sidney Hecht
IPC: C07C46/02 , C07C49/753 , C07C225/06 , C07C225/20 , C07D225/06 , A61K9/00 , A61K9/08 , A61K9/20 , A61K9/48 , C07C229/10
CPC classification number: C07C49/753 , A61K9/0019 , A61K9/008 , A61K9/08 , A61K9/2018 , A61K9/2054 , A61K9/4858 , C07C46/02 , C07C225/20 , C07C229/10 , C07D225/06 , C07C50/28
Abstract: The invention provides a compound of formula (I): [insert formula (I)] wherein X, Y, and R1-R4 have any of the values defined in the specification, and salts thereof, as well as compositions comprising the compounds or salts. The compounds are useful for treating diseases associated with impaired mitochondrial function in an animal.
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公开(公告)号：US10532109B2
公开(公告)日：2020-01-14
申请号：US16301888
申请日：2017-05-08
Inventor： Shengxi Chen , Yanmin Zhang , Sidney Hecht
Abstract: Provided herein are therapeutic agents having specificity for having inhibitory activity against cancer cells that overexpress human epidermal growth factor receptor (HER) genes, including therapeutic agents comprising one or more HER-targeting peptides, pharmaceutical compositions comprising such therapeutic agents, and methods of using such compositions to treat or prevent a cancer or other disease condition associated with HER overexpression.
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公开(公告)号：US10472340B2
公开(公告)日：2019-11-12
申请号：US15550282
申请日：2016-02-17
Inventor： Sidney Hecht , Omar Khdour , Sandipan Roy Chowdhury , Indrajit Bandyopadhyay
IPC: A61K31/5415 , C07D279/18 , C07D279/20 , C07D417/04 , C07D417/14
Abstract: The present disclosure provides phenothiazine derivative compounds and salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
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公开(公告)号：US11357848B2
公开(公告)日：2022-06-14
申请号：US15863118
申请日：2018-01-05
Inventor： Yung Chang , Sidney Hecht , Joseph Leal , Viswanath Arutla , Xiaowei Liu , Sriram Sokalingam
IPC: A61K39/385 , C07D401/14 , G16B15/00 , G16B20/00 , A61K47/64 , G01N33/94 , A61K39/00 , G16B15/30 , G16B20/30
Abstract: Provided herein are methods for rational design of nicotine haptens. More particularly, provided herein are methods for designing, selecting, and synthesizing nicotine haptens and nicotine hapten conjugates. Also provided herein are novel nicotine haptens and methods for using nicotine haptens to treat nicotine addiction.
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公开(公告)号：US11034662B2
公开(公告)日：2021-06-15
申请号：US16659308
申请日：2019-10-21
Inventor： Sidney Hecht , Omar Khdour , Sandipan Roy Chowdhury , Indrajit Bandyopadhyay
IPC: C07D279/18 , C07D279/20 , C07D417/04 , C07D417/14
Abstract: The invention provides compounds formula (I) and salts thereof: wherein R1, R2, R3, R6 and Y have any of the values defined in the specification. The compounds are useful for treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
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