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公开(公告)号：US10011649B2
公开(公告)日：2018-07-03
申请号：US14913089
申请日：2014-08-25
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , Christopher Diehnelt , Nidhi Gupta , Valeriy Domenyuk , Zhan-Gong Zhao , Stephen Johnston
IPC分类号： C07K16/28 , A61K38/00 , A61K39/395 , A61K39/00 , G01N33/53 , C07K16/10 , C07K14/11 , C07K14/00 , G01N33/569
CPC分类号： C07K16/1018 , A61K38/00 , C07K14/001 , C07K14/11 , C07K2318/20 , G01N33/56983 , G01N2333/11 , G01N2469/10
摘要： Composition of synbodies that bind influenza. The synbodies are composed of two peptides joined on a scaffold.
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公开(公告)号：US20120065123A1
公开(公告)日：2012-03-15
申请号：US13256500
申请日：2010-03-23
申请人： Stephen A. Johnston , Neal Woodbury , Christopher Diehnelt , Paul Belcher , Nidhi Gupta , Zhan-Gong Zhao , Matthew Greving , Jack Emery , Hao Yan , John Chaput
发明人： Stephen A. Johnston , Neal Woodbury , Christopher Diehnelt , Paul Belcher , Nidhi Gupta , Zhan-Gong Zhao , Matthew Greving , Jack Emery , Hao Yan , John Chaput
CPC分类号： G01N33/6845 , C07K2318/20 , G01N33/6854 , G01N2500/04
摘要： Methods for synthetic antibodies, methods for making synthetic antibodies, methods for identifying ligands, and related methods and reagents.
摘要翻译： 合成抗体的方法，制备合成抗体的方法，鉴别配体的方法以及相关方法和试剂。
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公开(公告)号：US20120021967A1
公开(公告)日：2012-01-26
申请号：US12989156
申请日：2009-04-23
申请人： Stephen A. Johnston , Neal Woodbury , Christopher Diehnelt , Paul Belcher , Nidhi Gupta , Zhan-Gong Zhao , Matthew Greving , Jack Emery
发明人： Stephen A. Johnston , Neal Woodbury , Christopher Diehnelt , Paul Belcher , Nidhi Gupta , Zhan-Gong Zhao , Matthew Greving , Jack Emery
CPC分类号： G01N33/6845 , C07K7/06 , C07K7/08
摘要： The present invention provides methods for synthetic antibodies, methods for making synthetic antibodies, methods for identifying ligands, and related methods and reagents.
摘要翻译： 本发明提供合成抗体的方法，制备合成抗体的方法，鉴定配体的方法以及相关方法和试剂。
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公开(公告)号：US20120220540A1
公开(公告)日：2012-08-30
申请号：US13410162
申请日：2012-03-01
IPC分类号： A61K38/16 , A61P35/00 , C07K14/00 , G01N33/573
CPC分类号： C12Q1/485 , C07K16/30 , C07K16/40 , C07K2318/20 , G01N33/57415 , G01N33/57434 , G01N33/57449
摘要： The present application provides synbodies against AKT1 differing in amino acid sequence, conjugation chemistry, linker/scaffold, or adjunct moiety. The synbodies are useful for diagnosis and treatment of cancer and as research reagents.
摘要翻译： 本申请提供了针对氨基酸序列，缀合化学，接头/支架或辅助部分不同的AKT1的抗体。 合成体可用于诊断和治疗癌症和研究试剂。
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公开(公告)号：US20130224730A1
公开(公告)日：2013-08-29
申请号：US13510161
申请日：2010-11-16
申请人： Stephen A. Johnston , Christopher Diehnelt , Paul Belcher , Charles J. Arntzen , Robert Sutherland
发明人： Stephen A. Johnston , Christopher Diehnelt , Paul Belcher , Charles J. Arntzen , Robert Sutherland
CPC分类号： C12N7/02 , C07K1/22 , C07K7/08 , C12Q1/701 , G01N33/56983 , G01N33/6845 , G01N2333/08
摘要： A method of solid phase selection of peptide ligands for target proteins is presented. 15-20mers or greater are addressed in a microarray, and the target protein and optional competitor bound thereto and binding compared. A specific signal for the target protein indicates that a peptide has strong affinity for the target. Ligands can be coupled to solid supports and used for affinity purification of the target proteins as well as detection and modulation of target proteins. Specific peptide ligands for immuno-purifying norovirus.
摘要翻译： 提出了靶蛋白肽配体的固相选择方法。 15-20mer或更大的在微阵列中被寻址，并且靶蛋白和与其结合的可选择的竞争物并进行结合比较。 靶蛋白的特定信号表明肽对靶具有强亲和力。 配体可以与固体支持物偶联并用于靶蛋白的亲和纯化以及靶蛋白的检测和调节。 用于免疫纯化诺如病毒的特异性肽配体。
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