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    Pyrazolo (3, 4-B) pyridine derivatives as phosphodiesterase inhibitors
    6.
    发明授权
    Pyrazolo (3, 4-B) pyridine derivatives as phosphodiesterase inhibitors 有权
    吡唑并（3,4-B）吡啶衍生物作为磷酸二酯酶抑制剂

    公开(公告)号：US08420666B2

    公开(公告)日：2013-04-16

    申请号：US12531043

    申请日：2008-03-14

    申请人： Sonali Rudra ,  Nidhi Gupta ,  Lalit Kumar Baregama ,  Ritu Agarwal ,  Vinayak Vasantrao Khairnar ,  Mandadapu Raghu Ramaiah ,  Venkata P. Palle ,  Sarala Balachandran ,  Atul Kondaskar ,  Manohar Salla ,  Abhijit Ray ,  Sunanda G. Dastidar ,  Lalitha Vijaykrishnan

    发明人： Sonali Rudra ,  Nidhi Gupta ,  Lalit Kumar Baregama ,  Ritu Agarwal ,  Vinayak Vasantrao Khairnar ,  Mandadapu Raghu Ramaiah ,  Venkata P. Palle ,  Sarala Balachandran ,  Atul Kondaskar ,  Manohar Salla ,  Abhijit Ray ,  Sunanda G. Dastidar ,  Lalitha Vijaykrishnan

    IPC分类号： C07D513/02 ,  C07D515/02 ,  A01N43/42 ,  A61K31/44

    CPC分类号： C07D471/04 ,  C07D519/00

    摘要： The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors. Compounds disclosed herein having the structure of Formula 1: can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affecting the immune system, including AIDS, rejection of transplant, auto-immune disorders such as T-cell related diseases, for example, rheumatoid arthritis; inflammatory diseases such as respiratory inflammation diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic rhinitis, adult respiratory distress syndrome (ARDS) and other inflammatory diseases including but not limited to psoriasis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis; gastrointestinal inflammation diseases such as Crohn's disease, colitis, pancreatitis as well as different types of cancers including leukaemia; especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type 4, PDE type 7 and dual PDE type 4/PDE type 7 inhibitors are provided.

    摘要翻译： 本发明涉及磷酸二酯酶（PDE）4型，磷酸二酯酶（PDE）7型和双重PDE型4 / PDE型7型抑制剂。 本文公开的具有式1结构的化合物可用于治疗，预防，抑制或抑制CNS疾病，例如多发性硬化; 各种病理状况如影响免疫系统的疾病，包括艾滋病，移植排斥反应，自身免疫性疾病如T细胞相关疾病，例如类风湿性关节炎; 炎性疾病如呼吸道炎症疾病，包括慢性阻塞性肺疾病（COPD），哮喘，支气管炎，过敏性鼻炎，成人呼吸窘迫综合征（ARDS）和其他炎性疾病，包括但不限于银屑病，休克，特应性皮炎，嗜酸性肉芽肿，过敏性 结膜炎，骨关节炎; 胃肠道炎症性疾病如克罗恩病，结肠炎，胰腺炎以及不同类型的癌症，包括白血病; 特别是在人类。 提供了制备所公开的化合物的方法，含有所公开的化合物的药物组合物及其作为PDE 4型，PDE型7和双重PDE型4 / PDE 7型抑制剂的用途。

    System for assisting creation of messages by automatically recommending data to be included therein
    9.
    发明授权
    System for assisting creation of messages by automatically recommending data to be included therein 有权
    用于通过自动推荐要包括在其中的数据来辅助创建消息的系统

    公开(公告)号：US09117178B1

    公开(公告)日：2015-08-25

    申请号：US13652378

    申请日：2012-10-15

    申请人： Kwan-Min Chiu ,  Daniel-Augustin Grad ,  Nidhi Gupta

    发明人： Kwan-Min Chiu ,  Daniel-Augustin Grad ,  Nidhi Gupta

    IPC分类号： G06F15/18 ,  G06F17/30 ,  G06N99/00 ,  G06F17/18

    CPC分类号： G06N99/005 ,  G06F15/18 ,  G06F17/18 ,  G06F17/30 ,  G06Q10/00

    摘要： Embodiments of the present invention are directed to a system for assisting creation of messages, by automatically recommending data to be included therein. The system includes an application configured to accept a set of user inputs of a first classification to determine and provide a group of suggested data relevant to the set of user inputs of the first classification. The group of data is chosen from an evolving collection of data of a second classification. The user is able to select any or all from the group of suggested data to adopt as the user's own and/or to provide additional or different data, which are of the second classification. The user inputs and the user's selection(s) are values collected for use in subsequent determinations.

    摘要翻译： 本发明的实施例涉及一种通过自动推荐要包括在其中的数据来辅助消息产生的系统。 该系统包括被配置为接受第一分类的一组用户输入的应用以确定并提供与第一类别的用户输入集相关的一组建议数据。 数据组是从不断变化的第二分类数据集中选出的。 用户能够从建议数据组中选择任何一个或全部，以作为用户自己和/或提供附加或不同的数据，这是第二类。 用户输入和用户的选择是收集的值，用于后续确定。

    System for assisting creation of messages by providing selectable templates
    10.
    发明授权
    System for assisting creation of messages by providing selectable templates 有权
    通过提供可选择的模板来协助创建消息的系统

    公开(公告)号：US09529788B1

    公开(公告)日：2016-12-27

    申请号：US13652357

    申请日：2012-10-15

    申请人： Nidhi Gupta ,  Jeff Ligh ,  Song SunMin Sunny

    发明人： Nidhi Gupta ,  Jeff Ligh ,  Song SunMin Sunny

    IPC分类号： G06F17/00 ,  G06F17/21 ,  G06F17/24

    CPC分类号： G06F17/243 ,  G06F17/212 ,  G06F17/248

    摘要： Embodiments of the present invention are directed to a system for assisting creation of messages by providing selectable templates. The system includes an application configured to provide a form which receives information. The form is configured based on a template, such as a default template or an alternate template. A user is able to switch between templates any time during the process of completing the form. The templates share one or more common fields. The application is configured to persist user data associated with at least one of the one or more common fields. The application is also configured to refresh/update the form with relevant fields and editable content associated with a template, and any persisted user data upon selection of that template. In some embodiments, the alternate templates include templates based on posts previously completed by the user and/or canned templates which are category-specific.

    摘要翻译： 本发明的实施例涉及一种通过提供可选模板来辅助消息创建的系统。 该系统包括被配置为提供接收信息的表单的应用。 该表单是基于模板配置的，例如默认模板或备用模板。 在完成表单的过程中，用户可以随时在模板之间切换。 模板共享一个或多个常见字段。 该应用被配置为持续与一个或多个公共字段中的至少一个相关联的用户数据。 该应用还被配置为刷新/更新与相关字段和与模板相关联的可编辑内容的表单，以及在选择该模板时的任何持久化的用户数据。 在一些实施例中，替代模板包括基于先前由用户完成的帖子和/或类别特定的模板。