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公开(公告)号：US09493426B2
公开(公告)日：2016-11-15
申请号：US14787089
申请日：2014-04-25
发明人： Patrick René Angibaud , Olivier Alexis Georges Querolle , Isabelle Noëlle Constance Pilatte , Lieven Meerpoel , Virginie Sophie Poncelet
IPC分类号： C07D239/91 , A61K45/06 , A61K31/517 , C07D403/12 , C07D401/14 , C07D405/04 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14
CPC分类号： C07D239/91 , A61K31/517 , A61K45/06 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14
摘要： The invention relates to new quinazolinone derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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![Substituted pyrido[2,3-b]pyrazines as FGFR kinase inhibitors](/abs-image/US/2018/08/14/US10045982B2/abs.jpg.150x150.jpg)
公开(公告)号：US10045982B2
公开(公告)日：2018-08-14
申请号：US15019563
申请日：2016-02-09
发明人： Valerio Berdini , Gordon Saxty , Patrick Rene Angibaud , Olivier Alexis Georges Querolle , Virginie Sophie Poncelet , Bruno Roux , Lieven Meerpoel
IPC分类号： C07D471/04 , A61K31/4985 , A61K31/506 , A61K31/5377
CPC分类号： A61K31/4985 , A61K31/506 , A61K31/5377 , C07D471/04
摘要： The invention relates to new pyridopyrazine derivative compounds of formula (I-A) or formula (I-B): to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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公开(公告)号：US20150239883A1
公开(公告)日：2015-08-27
申请号：US14404188
申请日：2013-05-30
IPC分类号： C07D471/04 , A61K45/06 , A61K31/5377 , A61K31/5025 , A61K31/4375
CPC分类号： A61K31/5377 , A61K31/4375 , A61K31/4985 , A61K31/5025 , A61K45/06 , C07D403/04 , C07D471/04
摘要： The invention relates to new pyridopyrazine and naphthyridine derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译： 本发明涉及新的吡啶并吡嗪衍生物化合物，包含所述化合物的药物组合物，用于制备所述化合物的方法以及所述化合物在治疗疾病中的用途。 癌症。
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公开(公告)号：US20150031669A1
公开(公告)日：2015-01-29
申请号：US14354636
申请日：2012-10-26
发明人： Steven John Woodhead , Christopher William Murray , Valerio Berdini , Gordon Saxty , Gilbert Ebai Besong , Lieven Meerpoel , Olivier Alexis Georges Querolle , Virginie Sophie Poncelet
IPC分类号： C07D471/04 , A61K31/4985 , C07D403/04 , C07D405/14 , A61K45/06 , C07D241/42 , C07D413/04 , A61K31/506 , C07D405/04 , C07D417/04 , C07D401/04 , C07D401/14
CPC分类号： A61K31/498 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D241/42 , C07D241/44 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/14 , C07D407/04 , C07D407/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D471/04
摘要： The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译： 本发明涉及新的喹喔啉衍生物化合物，包含所述化合物的药物组合物，用于制备所述化合物的方法和所述化合物在治疗疾病中的用途。 癌症。
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![Substituted pyrido[2,3-b]pyrazines as FGFR kinase inhibitors](/abs-image/US/2016/04/12/US09309242B2/abs.jpg.150x150.jpg)
公开(公告)号：US09309242B2
公开(公告)日：2016-04-12
申请号：US14354832
申请日：2012-10-26
发明人： Valerio Berdini , Gordon Saxty , Patrick Rene Angibaud , Olivier Alexis Georges Querolle , Virginie Sophie Poncelet , Bruno Roux , Lieven Meerpoel
IPC分类号： A61K31/4985 , C07D241/36 , C07D471/04 , A61K31/506 , A61K31/5377
CPC分类号： A61K31/4985 , A61K31/506 , A61K31/5377 , C07D471/04
摘要： The invention relates to new pyridopyrazine derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译： 本发明涉及新的吡啶并吡嗪衍生物化合物，包含所述化合物的药物组合物，用于制备所述化合物的方法以及所述化合物在治疗疾病中的用途。 癌症。
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公开(公告)号：US20140288053A1
公开(公告)日：2014-09-25
申请号：US14354832
申请日：2012-10-26
发明人： Valerio Berdini , Gordon Saxty , Patrick Rene Angibaud , Olivier Alexis Georges Querolle , Virginie Sophie Poncelet , Bruno Roux , Lieven Meerpoel
IPC分类号： C07D471/04 , A61K31/506 , A61K31/5377 , A61K31/4985
CPC分类号： A61K31/4985 , A61K31/506 , A61K31/5377 , C07D471/04
摘要： The invention relates to new pyridopyrazine derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译： 本发明涉及新的吡啶并吡嗪衍生物化合物，包含所述化合物的药物组合物，用于制备所述化合物的方法以及所述化合物在治疗疾病中的用途。 癌症。
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公开(公告)号：US10272087B2
公开(公告)日：2019-04-30
申请号：US15203424
申请日：2016-07-06
发明人： Gordon Saxty , Christopher Charles Frederick Hamlett , Valerio Berdini , Christopher William Murray , Patrick René Angibaud , Olivier Alexis Georges Querolle , Virginie Sophie Poncelet
IPC分类号： C07D475/00 , A61K31/519 , A61K45/06
摘要： The invention relates to new pteridine derivative compounds, of formula (I), to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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公开(公告)号：US10052320B2
公开(公告)日：2018-08-21
申请号：US15014156
申请日：2016-02-03
发明人： Steven John Woodhead , Christopher William Murray , Valerio Berdini , Gordon Saxty , Gilbert Ebai Besong , Lieven Meerpoel , Olivier Alexis Georges Querolle , Virginie Sophie Poncelet
IPC分类号： A61K31/498 , C07D241/40 , C07D403/12 , C07D401/14 , C07D413/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D407/04 , C07D407/14 , C07D413/04 , C07D417/04 , C07D241/42 , C07D241/44 , C07D417/12 , C07D471/04 , A61K31/4985 , A61K31/506 , A61K45/06 , C07D405/04 , C07D405/14 , A61K31/5377
CPC分类号： A61K31/498 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D241/42 , C07D241/44 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/14 , C07D407/04 , C07D407/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D471/04
摘要： The invention relates to new quinoxaline derivative compounds of formula (I), to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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公开(公告)号：US09737544B2
公开(公告)日：2017-08-22
申请号：US15000304
申请日：2016-01-19
IPC分类号： A61K31/5377 , A61K31/4375 , A61K31/5025 , A61K31/4985 , C07D403/04 , A61K45/06 , C07D471/04
CPC分类号： A61K31/5377 , A61K31/4375 , A61K31/4985 , A61K31/5025 , A61K45/06 , C07D403/04 , C07D471/04
摘要： The invention relates to new pyridopyrazine and naphthyridine derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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公开(公告)号：US09303029B2
公开(公告)日：2016-04-05
申请号：US14354636
申请日：2012-10-26
发明人： Steven John Woodhead , Christopher William Murray , Valerio Berdini , Gordon Saxty , Gilbert Ebai Besong , Lieven Meerpoel , Olivier Alexis Georges Querolle , Virginie Sophie Poncelet
IPC分类号： A61K31/498 , C07D241/42 , C07D471/04 , C07D403/12 , C07D401/14 , C07D413/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D407/04 , C07D407/14 , C07D413/04 , C07D417/04 , C07D241/44 , C07D417/12 , A61K31/4985 , A61K31/506 , A61K45/06 , C07D405/04 , C07D405/14
CPC分类号： A61K31/498 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D241/42 , C07D241/44 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/14 , C07D407/04 , C07D407/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D471/04
摘要： The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译： 本发明涉及新的喹喔啉衍生物化合物，包含所述化合物的药物组合物，用于制备所述化合物的方法和所述化合物在治疗疾病中的用途。 癌症。
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