公开(公告)号：US11981618B2

公开(公告)日：2024-05-14

申请号：US17262129

申请日：2019-07-24

申请人： AUTOTAC INC.

发明人： Yong Tae Kwon ,  Chang Hoon Ji ,  Srinivasrao Ganipisetti ,  Hee Yeon Kim ,  Su Ran Mun ,  Chan Hoon Jung ,  Eui Jung Jung ,  Ki Woon Sung

IPC分类号： C07C217/58 ,  A23L33/10 ,  A61K31/05 ,  A61K31/12 ,  A61K31/138 ,  A61K31/166 ,  A61K31/192 ,  A61K31/277 ,  A61K31/336 ,  A61K31/355 ,  A61K31/4015 ,  A61K31/4155 ,  A61K31/4184 ,  A61K31/421 ,  A61K31/428 ,  A61K31/4535 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/50 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/5415 ,  A61K31/551 ,  A61K31/565 ,  A61K39/395 ,  A61K47/54 ,  A61K47/55 ,  A61K47/68 ,  A61P25/28 ,  C07C43/23 ,  C07C47/575 ,  C07C235/06 ,  C07C237/06 ,  C07C275/24 ,  C07C279/12 ,  C07D303/18

CPC分类号： C07C217/58 ,  A23L33/10 ,  A61K31/05 ,  A61K31/12 ,  A61K31/138 ,  A61K31/166 ,  A61K31/192 ,  A61K31/277 ,  A61K31/336 ,  A61K31/355 ,  A61K31/4015 ,  A61K31/4155 ,  A61K31/4184 ,  A61K31/421 ,  A61K31/428 ,  A61K31/4535 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/50 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/5415 ,  A61K31/551 ,  A61K31/565 ,  A61K39/3955 ,  A61K47/54 ,  A61K47/55 ,  A61K47/6803 ,  A61K47/6849 ,  A61P25/28 ,  C07C43/23 ,  C07C47/575 ,  C07C235/06 ,  C07C237/06 ,  C07C275/24 ,  C07C279/12 ,  C07D303/18 ,  C07B2200/07

摘要： The present invention relates to a novel p62 ligand compound, a stereoisomer, hydrate, solvate or prodrug thereof, and a pharmaceutical or food composition for preventing or treating proteinopathies comprising the same as an active ingredient. The p62 ligand compound according to the present invention can be usefully used as a pharmaceutical composition for the prevention, amelioration or treatment of various proteinopathies by activating autophagy in cells and thus selectively eliminating in vivo proteins, organelles and aggregates.

公开(公告)号：US12129218B2

公开(公告)日：2024-10-29

申请号：US17262157

申请日：2019-07-24

申请人： AUTOTAC INC.

发明人： Yong Tae Kwon ,  Chang Hoon Ji ,  Srinivasrao Ganipisetti ,  Hee Yeon Kim ,  Su Ran Mun ,  Chan Hoon Jung ,  Eui Jung Jung ,  Ki Woon Sung

IPC分类号： A61K39/395 ,  A23L33/10 ,  A61K31/05 ,  A61K31/12 ,  A61K31/138 ,  A61K31/166 ,  A61K31/192 ,  A61K31/277 ,  A61K31/336 ,  A61K31/355 ,  A61K31/4015 ,  A61K31/4155 ,  A61K31/4184 ,  A61K31/421 ,  A61K31/428 ,  A61K31/4535 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/50 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/5415 ,  A61K31/551 ,  A61K31/565 ,  A61K47/54 ,  A61K47/55 ,  A61K47/68 ,  A61P25/28 ,  C07C43/23 ,  C07C47/575 ,  C07C217/58 ,  C07C235/06 ,  C07C237/06 ,  C07C275/24 ,  C07C279/12 ,  C07D303/18

CPC分类号： C07C217/58 ,  A23L33/10 ,  A61K31/05 ,  A61K31/12 ,  A61K31/138 ,  A61K31/166 ,  A61K31/192 ,  A61K31/277 ,  A61K31/336 ,  A61K31/355 ,  A61K31/4015 ,  A61K31/4155 ,  A61K31/4184 ,  A61K31/421 ,  A61K31/428 ,  A61K31/4535 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/50 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/5415 ,  A61K31/551 ,  A61K31/565 ,  A61K39/3955 ,  A61K47/54 ,  A61K47/55 ,  A61K47/6803 ,  A61K47/6849 ,  A61P25/28 ,  C07C43/23 ,  C07C47/575 ,  C07C235/06 ,  C07C237/06 ,  C07C275/24 ,  C07C279/12 ,  C07D303/18 ,  C07B2200/07

摘要： The present invention relates to a novel AUTOTAC chimeric compound in which a new p62 ligand and a target-binding ligand are connected by a linker, a stereoisomer, hydrate, solvate or prodrug thereof, and a pharmaceutical or food composition for the prevention or treatment of diseases by degrading the target protein including the same as an active ingredient. They can target specific proteins to adjust their concentrations, and can also deliver drugs and other small molecule compounds to lysosomes. The AUTOTAC chimeric compound according to the present invention can be usefully used as a pharmaceutical composition for the prevention, amelioration or treatment of various diseases by selectively eliminating specific proteins.

公开(公告)号：US20230190938A1

公开(公告)日：2023-06-22

申请号：US18169734

申请日：2023-02-15

申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  PROTECH CO., LTD. ,  AUTOTAC INC.

发明人： Yong Tae Kwon ,  Chang Hoon Ji ,  Srinivasrao Ganipisetti ,  Hee Yeon Kim ,  Su Ran Mun ,  Chan Hoon Jung ,  Eui Jung Jung ,  Ki Woon Sung ,  Hyun Tae Kim ,  Jeong Eun Na ,  Eun Hye Jeong ,  Ji Eun Lee ,  Min Ju Lee ,  Chang Min Park ,  Su Jin Kim

IPC分类号： A61K47/54 ,  A61K47/55

CPC分类号： A61K47/545 ,  A61K47/55

摘要： One aspect of the disclosure relates to a cargo delivery system comprising an autophagy targeting ligand and a target-binding ligand. In one aspect of the disclosure, by comprising an autophagy targeting ligand, cargo, which is a target-binding ligand that specifically binds to a target, is delivered to the p62 protein and autophagy is activated, so that depending on the type of target-binding ligand used, a target to be degraded can be selectively and directly removed. Accordingly, the cargo delivery system according to an aspect of the disclosure may be used in pharmaceutical compositions or food compositions for preventing, alimerating, and treating various diseases.