公开(公告)号：US11642244B2

公开(公告)日：2023-05-09

申请号：US16987370

申请日：2020-08-06

Applicant: Avedro, Inc.

Inventor： Desmond C. Adler ,  Mikhail Smirnov ,  David Usher ,  Behrouz Tavakol ,  Jason Hill ,  Jie Zhang ,  Amit Mukherjee ,  Alex Yildizyan

IPC: A61F9/008

CPC classification number: A61F9/008 ,  A61F2009/00844 ,  A61F2009/00872 ,  A61F2009/00897

Abstract: A system for treating an eye includes a laser light source providing photoactivating light. The system includes a scanning system to receive the photoactivating light as a laser beam and to move the laser beam over a cornea treated with a cross-linking agent. The system includes a controller that provides control signal(s) to programmatically control the laser light source and the scanning system. The control signal(s) cause the laser beam to visit region(s) of the cornea more than once according to a scan pattern and expose the region(s) to the photoactivating light. The photoactivating light causes the cross-linking agent in the exposed region(s) to react with oxygen to generate cross-linking activity in the exposed region(s). The scan pattern causes a predetermined period of time to pass between visits by the laser beam to the exposed region(s), the predetermined period of time allowing oxygen in the exposed region(s) to replenish.

公开(公告)号：US20210038428A1

公开(公告)日：2021-02-11

申请号：US16987370

申请日：2020-08-06

Applicant: Avedro, Inc.

Inventor： Desmond C. Adler ,  Mikhail Smirnov ,  David Usher ,  Behrouz Tavakol ,  Jason Hill ,  Jie Zhang ,  Amit Mukherjee ,  Alex Yildizyan

IPC: A61F9/008

Abstract: A system for treating an eye includes a laser light source providing photoactivating light. The system includes a scanning system to receive the photoactivating light as a laser beam and to move the laser beam over a cornea treated with a cross-linking agent. The system includes a controller that provides control signal(s) to programmatically control the laser light source and the scanning system. The control signal(s) cause the laser beam to visit region(s) of the cornea more than once according to a scan pattern and expose the region(s) to the photoactivating light. The photoactivating light causes the cross-linking agent in the exposed region(s) to react with oxygen to generate cross-linking activity in the exposed region(s). The scan pattern causes a predetermined period of time to pass between visits by the laser beam to the exposed region(s), the predetermined period of time allowing oxygen in the exposed region(s) to replenish.

公开(公告)号：US12293513B2

公开(公告)日：2025-05-06

申请号：US17689515

申请日：2022-03-08

Applicant: AVEDRO, INC.

Inventor： David Usher ,  Mikhail Smirnov ,  Behrouz Tavakol ,  Grace Lytle

IPC: G06T7/00 ,  A61B3/10 ,  A61P27/02

Abstract: An automated process receives input tomography data and generates an optimized (customized) treatment pattern for an individual patient without relying on the physician's analysis and judgment. For example, a method for treating a cornea includes receiving tomographic data for a cornea. The method includes identifying a keratoconic defect in the cornea based on the tomographic data. The method includes segmenting the keratoconic defect into treatment zones based on predefined geometric parameters, wherein the treatment zones indicate where a cross-linking agent is to be applied on the cornea and photoactivated to treat the keratoconic defect.

公开(公告)号：US20250161114A1

公开(公告)日：2025-05-22

申请号：US19030052

申请日：2025-01-17

Applicant: Avedro, Inc.

Inventor： Desmond C. Adler ,  Mikhail Smirnov ,  David Usher ,  Behrouz Tavakol ,  Jason Hill ,  Jie Zhang ,  Amit Mukherjee ,  Alex Yildizyan

IPC: A61F9/008

Abstract: A system for treating an eye includes a laser light source providing photoactivating light. The system includes a scanning system to receive the photoactivating light as a laser beam and to move the laser beam over a cornea treated with a cross-linking agent. The system includes a controller that provides control signal(s) to programmatically control the laser light source and the scanning system. The control signal(s) cause the laser beam to visit region(s) of the cornea more than once according to a scan pattern and expose the region(s) to the photoactivating light. The photoactivating light causes the cross-linking agent in the exposed region(s) to react with oxygen to generate cross-linking activity in the exposed region(s). The scan pattern causes a predetermined period of time to pass between visits by the laser beam to the exposed region(s), the predetermined period of time allowing oxygen in the exposed region(s) to replenish.

公开(公告)号：US20250166188A1

公开(公告)日：2025-05-22

申请号：US19030228

申请日：2025-01-17

Applicant: Avedro, Inc.

Inventor： David Usher ,  Mikhail Smirnov ,  Behrouz Tavakol ,  Grace Elizabeth Lytle

IPC: G06T7/00 ,  A61B3/10 ,  A61P27/02

Abstract: An automated process receives input tomography data and generates an optimized (customized) treatment pattern for an individual patient without relying on the physician's analysis and judgment. For example, a method for treating a cornea includes receiving tomographic data for a cornea. The method includes identifying a keratoconic defect in the cornea based on the tomographic data. The method includes segmenting the keratoconic defect into treatment zones based on predefined geometric parameters, wherein the treatment zones indicate where a cross-linking agent is to be applied on the cornea and photoactivated to treat the keratoconic defect.

公开(公告)号：US20230346601A1

公开(公告)日：2023-11-02

申请号：US18313078

申请日：2023-05-05

Applicant: Avedro, Inc.

Inventor： Desmond C. Adler ,  Mikhail Smirnov ,  David Usher ,  Behrouz Tavakol ,  Jason Hill ,  Jie Zhang ,  Amit Mukherjee ,  Alex Yildizyan

IPC: A61F9/008

CPC classification number: A61F9/008 ,  A61F2009/00844 ,  A61F2009/00897 ,  A61F2009/00872

Abstract: A system for treating an eye includes a laser light source providing photoactivating light. The system includes a scanning system to receive the photoactivating light as a laser beam and to move the laser beam over a cornea treated with a cross-linking agent. The system includes a controller that provides control signal(s) to programmatically control the laser light source and the scanning system. The control signal(s) cause the laser beam to visit region(s) of the cornea more than once according to a scan pattern and expose the region(s) to the photoactivating light. The photoactivating light causes the cross-linking agent in the exposed region(s) to react with oxygen to generate cross-linking activity in the exposed region(s). The scan pattern causes a predetermined period of time to pass between visits by the laser beam to the exposed region(s), the predetermined period of time allowing oxygen in the exposed region(s) to replenish.

公开(公告)号：US20220284575A1

公开(公告)日：2022-09-08

申请号：US17689515

申请日：2022-03-08

Applicant: AVEDRO, INC.

Inventor： David Usher ,  Mikhail Smirnov ,  Behrouz Tavakol ,  Grace Elizabeth Lytle

IPC: G06T7/00 ,  A61B3/10

Abstract: An automated process receives input tomography data and generates an optimized (customized) treatment pattern for an individual patient without relying on the physician's analysis and judgment. For example, a method for treating a cornea includes receiving tomographic data for a cornea. The method includes identifying a keratoconic defect in the cornea based on the tomographic data. The method includes segmenting the keratoconic defect into treatment zones based on predefined geometric parameters, wherein the treatment zones indicate where a cross-linking agent is to be applied on the cornea and photoactivated to treat the keratoconic defect.