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1.发明申请公开(公告)号：US20200229692A1
公开(公告)日：2020-07-23
申请号：US16840317
申请日：2020-04-03
Applicant: Avedro, Inc.
Inventor： Desmond Christopher Adler , Jun Zhang , Mikhail Z. Smirnov , Marc D. Friedman , David Usher , Grace Elizabeth Lytle , David C. Iannetta
Abstract: In a corneal measurement system, an optical element focuses an excitation light to an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to the cornea generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth.
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2.发明申请公开(公告)号：US20180206719A1
公开(公告)日：2018-07-26
申请号：US15868457
申请日：2018-01-11
Applicant: Avedro, Inc.
Inventor： Desmond Christopher Adler , Jun Zhang , Mikhail Z. Smirnov , Marc D. Friedman , David Usher , Grace Elizabeth Lytle , David C. Iannetta
Abstract: In a corneal measurement system, an optical element focuses an excitation light to an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to the cornea generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth.
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公开(公告)号：US11529050B2
公开(公告)日：2022-12-20
申请号：US16840317
申请日：2020-04-03
Applicant: Avedro, Inc.
Inventor： Desmond Christopher Adler , Jun Zhang , Mikhail Z. Smirnov , Marc D. Friedman , David Usher , Grace Elizabeth Lytle , David C. Iannetta
Abstract: In a corneal measurement system, an optical element focuses an excitation light to an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to the cornea generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth.
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Patent Agency Ranking
公开(公告)号：US20200085617A1
公开(公告)日：2020-03-19
申请号：US16575428
申请日：2019-09-19
Applicant: Avedro, Inc.
Inventor： Rajesh K. Rajpal , Grace Elizabeth Lytle
Abstract: To treat corneal ectatic disorders, systems and methods can precisely apply photoactivating light to specified areas of a cornea treated with a cross-linking agent. An example system includes a light source that provides a photoactivating light to photoactivate a cross-linking agent applied to an eye. The system includes optical element(s) that transmit the photoactivating light to the eye according to a pattern defined by a plurality of treatment zones. The treatment zones are delivered to different respective areas on the eye. The plurality of treatment zones includes at least a first treatment zone and a second treatment zone. The first treatment zone provides a first dose of the photoactivating light. The second treatment zone provides a second dose of the photoactivating light. The first dose is greater than the second dose. The first treatment zone is disposed within an inner boundary of the second treatment zone.
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5.发明申请公开(公告)号：US20250166188A1
公开(公告)日：2025-05-22
申请号：US19030228
申请日：2025-01-17
Applicant: Avedro, Inc.
Inventor： David Usher , Mikhail Smirnov , Behrouz Tavakol , Grace Elizabeth Lytle
Abstract: An automated process receives input tomography data and generates an optimized (customized) treatment pattern for an individual patient without relying on the physician's analysis and judgment. For example, a method for treating a cornea includes receiving tomographic data for a cornea. The method includes identifying a keratoconic defect in the cornea based on the tomographic data. The method includes segmenting the keratoconic defect into treatment zones based on predefined geometric parameters, wherein the treatment zones indicate where a cross-linking agent is to be applied on the cornea and photoactivated to treat the keratoconic defect.
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6.发明申请公开(公告)号：US20220284575A1
公开(公告)日：2022-09-08
申请号：US17689515
申请日：2022-03-08
Applicant: AVEDRO, INC.
Inventor： David Usher , Mikhail Smirnov , Behrouz Tavakol , Grace Elizabeth Lytle
Abstract: An automated process receives input tomography data and generates an optimized (customized) treatment pattern for an individual patient without relying on the physician's analysis and judgment. For example, a method for treating a cornea includes receiving tomographic data for a cornea. The method includes identifying a keratoconic defect in the cornea based on the tomographic data. The method includes segmenting the keratoconic defect into treatment zones based on predefined geometric parameters, wherein the treatment zones indicate where a cross-linking agent is to be applied on the cornea and photoactivated to treat the keratoconic defect.
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7.发明公开公开(公告)号：US20240335108A1
公开(公告)日：2024-10-10
申请号：US18738229
申请日：2024-06-10
Applicant: Avedro, Inc.
Inventor： Desmond Christopher Adler , Jun A. Zhang , Mikhail Z. Smirnov , Marc D. Friedman , David Usher , Grace Elizabeth Lytle , David C. Iannetta
CPC classification number: A61B3/107 , A61B3/10 , A61B3/14 , A61B5/0036 , A61F9/0079 , A61N5/062 , A61B5/0071 , A61B5/4848 , A61F2009/00872 , A61N2005/0661
Abstract: In a corneal measurement system, an optical element focuses an excitation light to an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to the cornea generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth.
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公开(公告)号：US12004811B2
公开(公告)日：2024-06-11
申请号：US18078728
申请日：2022-12-09
Applicant: Avedro, Inc.
Inventor： Desmond Christopher Adler , Jun A. Zhang , Mikhail Z. Smirnov , Marc D. Friedman , David Usher , Grace Elizabeth Lytle , David C. Iannetta
CPC classification number: A61B3/107 , A61B3/10 , A61B3/14 , A61B5/0036 , A61F9/0079 , A61N5/062 , A61B5/0071 , A61B5/4848 , A61F2009/00872 , A61N2005/0661
Abstract: In a corneal measurement system, an optical element focuses an excitation light to an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to the cornea generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth.
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