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    Systems and methods for generating patient-specific corneal cross-linking treatment patterns
    1.
    发明授权
    Systems and methods for generating patient-specific corneal cross-linking treatment patterns 有权

    公开(公告)号：US12293513B2

    公开(公告)日：2025-05-06

    申请号：US17689515

    申请日：2022-03-08

    Applicant: AVEDRO, INC.

    Inventor： David Usher ,  Mikhail Smirnov ,  Behrouz Tavakol ,  Grace Lytle

    IPC: G06T7/00 ,  A61B3/10 ,  A61P27/02

    Abstract: An automated process receives input tomography data and generates an optimized (customized) treatment pattern for an individual patient without relying on the physician's analysis and judgment. For example, a method for treating a cornea includes receiving tomographic data for a cornea. The method includes identifying a keratoconic defect in the cornea based on the tomographic data. The method includes segmenting the keratoconic defect into treatment zones based on predefined geometric parameters, wherein the treatment zones indicate where a cross-linking agent is to be applied on the cornea and photoactivated to treat the keratoconic defect.

    Systems and methods for eye tracking during eye treatment
    2.
    发明授权
    Systems and methods for eye tracking during eye treatment 有权

    公开(公告)号：US12042433B2

    公开(公告)日：2024-07-23

    申请号：US16978694

    申请日：2019-03-05

    Applicant: Avedro, Inc.

    Inventor： Desmond Christopher Adler ,  David Usher ,  Mikhail Smirnov

    IPC: A61F9/007 ,  A61F9/00

    CPC classification number: A61F9/0079 ,  A61F9/0008

    Abstract: A corneal cross-linking system includes a light source configured to emit a photoactivating light. The system includes a spatial light modulator configured to receive the photoactivating light from the light source and provide a pixelated illumination. The spatial light modulator defines a maximum area for the pixelated illumination. The system includes a controller configured to cause the spatial light modulator to project a first pixelated illumination onto the cornea to photoactivate a cross-linking agent applied to a treatment area. The first pixelated illumination has an area that is smaller than the maximum area defined by the spatial light modulator. The controller is configured to determine movement of the cornea. In response to the movement, the controller controls the spatial light modulator to project a second pixelated illumination to the treatment area based on a translation and/or transformation of the first pixelated illumination to continue photoactivating the cross-linking agent.

    Photoactivation systems and methods for corneal cross-linking treatments
    3.
    发明授权
    Photoactivation systems and methods for corneal cross-linking treatments 有权

    公开(公告)号：US11642244B2

    公开(公告)日：2023-05-09

    申请号：US16987370

    申请日：2020-08-06

    Applicant: Avedro, Inc.

    Inventor： Desmond C. Adler ,  Mikhail Smirnov ,  David Usher ,  Behrouz Tavakol ,  Jason Hill ,  Jie Zhang ,  Amit Mukherjee ,  Alex Yildizyan

    IPC: A61F9/008

    CPC classification number: A61F9/008 ,  A61F2009/00844 ,  A61F2009/00872 ,  A61F2009/00897

    Abstract: A system for treating an eye includes a laser light source providing photoactivating light. The system includes a scanning system to receive the photoactivating light as a laser beam and to move the laser beam over a cornea treated with a cross-linking agent. The system includes a controller that provides control signal(s) to programmatically control the laser light source and the scanning system. The control signal(s) cause the laser beam to visit region(s) of the cornea more than once according to a scan pattern and expose the region(s) to the photoactivating light. The photoactivating light causes the cross-linking agent in the exposed region(s) to react with oxygen to generate cross-linking activity in the exposed region(s). The scan pattern causes a predetermined period of time to pass between visits by the laser beam to the exposed region(s), the predetermined period of time allowing oxygen in the exposed region(s) to replenish.

    PHOTOACTIVATION SYSTEMS AND METHODS FOR CORNEAL CROSS-LINKING TREATMENTS
    4.
    发明申请
    PHOTOACTIVATION SYSTEMS AND METHODS FOR CORNEAL CROSS-LINKING TREATMENTS 有权

    公开(公告)号：US20210038428A1

    公开(公告)日：2021-02-11

    申请号：US16987370

    申请日：2020-08-06

    Applicant: Avedro, Inc.

    Inventor： Desmond C. Adler ,  Mikhail Smirnov ,  David Usher ,  Behrouz Tavakol ,  Jason Hill ,  Jie Zhang ,  Amit Mukherjee ,  Alex Yildizyan

    IPC: A61F9/008

    Abstract: A system for treating an eye includes a laser light source providing photoactivating light. The system includes a scanning system to receive the photoactivating light as a laser beam and to move the laser beam over a cornea treated with a cross-linking agent. The system includes a controller that provides control signal(s) to programmatically control the laser light source and the scanning system. The control signal(s) cause the laser beam to visit region(s) of the cornea more than once according to a scan pattern and expose the region(s) to the photoactivating light. The photoactivating light causes the cross-linking agent in the exposed region(s) to react with oxygen to generate cross-linking activity in the exposed region(s). The scan pattern causes a predetermined period of time to pass between visits by the laser beam to the exposed region(s), the predetermined period of time allowing oxygen in the exposed region(s) to replenish.

    Systems and methods for cross-linking treatments of an eye
    5.
    发明授权
    Systems and methods for cross-linking treatments of an eye 有权

    公开(公告)号：US10350111B2

    公开(公告)日：2019-07-16

    申请号：US15140184

    申请日：2016-04-27

    Applicant: Avedro, Inc.

    Inventor： Marc D. Friedman ,  Pavel Kamaev ,  Mikhail Smirnov

    IPC: A61N5/06 ,  A61F9/007 ,  A61F9/008

    Abstract: A system for corneal treatment includes a light source that activates cross-linking in at least one selected region of a cornea treated with a cross-linking agent. The light source delivers photoactivating light to the at least one selected region of the cornea according to a set of parameters. The system includes a controller that receives input relating to the cross-linking agent and the set of parameters. The controller includes computer-readable storage media storing: (A) program instructions for determining cross-linking resulting from reactions involving ROS including at least peroxides, superoxides, and hydroxyl radicals, and (B) program instructions for determining cross-linking from reactions not involving oxygen. The controller executes the program instructions to output a calculated amount of cross-linking in the at least one selected region of the cornea. In response to the calculated amount of cross-linking, the light source adjusts at least one value in the set of parameters.

    SYSTEMS AND METHODS FOR CROSS-LINKING TREATMENTS OF AN EYE
    6.
    发明申请
    SYSTEMS AND METHODS FOR CROSS-LINKING TREATMENTS OF AN EYE 审中-公开
    用于眼睛交联治疗的系统和方法

    公开(公告)号：US20160310319A1

    公开(公告)日：2016-10-27

    申请号：US15140184

    申请日：2016-04-27

    Applicant: Avedro, Inc.

    Inventor： Marc D. Friedman ,  Pavel Kamaev ,  Mikhail Smirnov

    IPC: A61F9/007 ,  A61F9/008

    CPC classification number: A61F9/0079 ,  A61F9/007 ,  A61F9/008 ,  A61F9/00825 ,  A61F2009/00851 ,  A61F2009/00872 ,  A61F2009/00893

    Abstract: A system for corneal treatment includes a light source that activates cross-linking in at least one selected region of a cornea treated with a cross-linking agent. The light source delivers photoactivating light to the at least one selected region of the cornea according to a set of parameters. The system includes a controller that receives input relating to the cross-linking agent and the set of parameters. The controller includes computer-readable storage media storing: (A) program instructions for determining cross-linking resulting from reactions involving ROS including at least peroxides, superoxides, and hydroxyl radicals, and (B) program instructions for determining cross-linking from reactions not involving oxygen. The controller executes the program instructions to output a calculated amount of cross-linking in the at least one selected region of the cornea. In response to the calculated amount of cross-linking, the light source adjusts at least one value in the set of parameters.

    Abstract translation: 用于角膜治疗的系统包括在用交联剂处理的角膜的至少一个选定区域中激活交联的光源。 光源根据一组参数将光活化光传送到角膜的至少一个选定区域。 该系统包括控制器，其接收与交联代理和该组参数相关的输入。 控制器包括计算机可读存储介质，其存储：（A）用于确定由包含至少过氧化物，超氧化物和羟基自由基的ROS的反应产生的交联的程序指令，和（B）用于确定反应的交联的程序说明 涉及氧气。 所述控制器执行所述程序指令以在所述角膜的所述至少一个选定区域中输出计算出的交联量。 响应于所计算的交联量，光源调整该组参数中的至少一个值。

    Systems and Methods for Cross-Linking Treatments of an Eye
    7.
    发明申请
    Systems and Methods for Cross-Linking Treatments of an Eye 有权

    公开(公告)号：US20220133533A1

    公开(公告)日：2022-05-05

    申请号：US17434275

    申请日：2020-02-26

    Applicant: Avedro, Inc.

    Inventor： Mikhail Smirnov

    IPC: A61F9/007

    Abstract: An example system for corneal treatment includes an illumination system to generate cross-linking in at least one selected region of a cornea treated with a cross-linking agent by delivering photoactivating light according to one or more photoactivation parameters. The system includes a controller to receive input relating to one or more treatment parameters, which include the one or more photoactivation parameters. The controller is configured to output information for adjusting the one or more treatment parameters by (A) determining from the input, a distribution of cross-links for the at least one selected region of the cornea; (B) determining, from the distribution of cross-links, a shape change for the cornea; and (C) determining, from the shape change for the cornea, a change in vision for the subject. Responsive to the output from the controller, the illumination system is configured to adjust at least one of the one or more photoactivation parameters.

    Systems and methods for photoactivating a photosensitizer applied to an eye
    9.
    发明授权
    Systems and methods for photoactivating a photosensitizer applied to an eye 有权

    公开(公告)号：US10258809B2

    公开(公告)日：2019-04-16

    申请号：US15137748

    申请日：2016-04-25

    Applicant: Avedro, Inc.

    Inventor： Marc D. Friedman ,  Mikhail Smirnov ,  Pavel Kamaev

    IPC: A61N5/06 ,  A61F9/02

    Abstract: An antimicrobial treatment system comprises a wearable photoactivation device. The wearable photoactivation device includes a body configured to be positioned on a head of a subject over one or more eyes of the subject. The body includes one or more windows or openings that allow the one or more eyes to see through the body. The body includes one or more photoactivating light sources coupled to the body and configured to direct photoactivating light to the one or more eyes according to illumination parameters. The illumination parameters determine a dose of the photoactivating light that activates, according to photochemical kinetic reactions, a photosensitizer applied to the one or more eyes and generates reactive oxygen species that provide an antimicrobial effect in the one or more eyes, without substantially inducing cross-linking activity that produces biomechanical changes in the one or more eyes.

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