公开(公告)号：US12196741B2

公开(公告)日：2025-01-14

申请号：US17425571

申请日：2020-01-27

Applicant: AXION BIOSYSTEMS, INC.

Inventor： Michael Antony Clements ,  Isaac Perry Clements ,  Thomas J. O'Brien ,  James David Ross ,  Daniel Christopher Millard ,  Andrew Willsie ,  Edgar A. Brown ,  Robert Dixon Grier, Jr. ,  Amanda Jervis Preyer ,  Denise Danielle Sullivan

IPC: G01N33/483 ,  G01N21/59 ,  G01N27/02 ,  G01N33/487

Abstract: A scalable, real-time, label-free, electrode- or optical-based cell monitoring system for integration into a cell culture incubator is described herein. An example system includes (1) cell culture consumables with integrated electrodes and/or optics for growing and monitoring cells, (2) incubator trays for consumable organization and recording, and (3) a system console, external to the incubator, for connecting multiple incubator trays. Without perturbing the cell culture, the system is capable of monitoring multiple culture attributes for each cell culture consumable simultaneously. These attributes can include, but are not limited to, cell growth, proliferation, morphology, media pH, or media oxygen. The system can support multiple trays, which permits monitoring dozens to hundreds of consumables simultaneously, including a mixture of consumables of various sizes. In addition to monitoring adherent cells, the disclosed technology can be readily adapted for monitoring of cell suspensions.

公开(公告)号：US20180064931A1

公开(公告)日：2018-03-08

申请号：US15697358

申请日：2017-09-06

Applicant: Axion BioSystems, Inc. ,  Virginia Commonwealth University

Inventor： Isaac Perry Clements ,  Andrew Willsie ,  James David Ross ,  Alex Weidenbach ,  Jonathan Isaacs

IPC: A61N1/05 ,  A61B5/04 ,  A61B5/00 ,  A61N1/36

CPC classification number: A61N1/0556 ,  A61B5/04001 ,  A61B5/6877 ,  A61B5/6882 ,  A61N1/0558 ,  A61N1/36103

Abstract: An example device for repairing a nerve is described herein. The device can include a flexible carrier layer made of a biologic material, and a metallic support member including a plurality of micro-protrusions extending therefrom. The metallic support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the nerve, and the micro-protrusions can be configured to attach to a superficial tissue of the nerve.