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    3D microelectrode device for live tissue applications
    2.
    发明授权
    3D microelectrode device for live tissue applications 有权
    用于活组织应用的3D微电极装置

    公开(公告)号：US09248273B2

    公开(公告)日：2016-02-02

    申请号：US13919013

    申请日：2013-06-17

    Applicant: Axion Biosystems, Inc. ,  Georgia Institute of Technology

    Inventor： Gareth S. Guvanasen ,  Swaminathan Rajaraman ,  Ricardo Aguilar, Jr. ,  Liang Guo ,  T. Richard Nichols ,  Stephen P. DeWeerth

    IPC: A61N1/05 ,  A61B5/04 ,  A61B5/0492 ,  H05K1/09 ,  H05K1/02

    CPC classification number: A61N1/0502 ,  A61B5/04001 ,  A61B5/0492 ,  A61B2562/0209 ,  A61B2562/125 ,  A61B2562/164 ,  A61N1/0551 ,  H05K1/0283 ,  H05K1/095 ,  H05K2201/0245 ,  H05K2201/10318

    Abstract: A 3D microelectrode device includes a flexible substrate containing poly-dimethyl siloxane (PDMS). The device may be fabricated in a miniature form factor suitable for attachment to a small organ such as a lateral gastrocnemius muscle of a live rat. In addition to providing a miniaturized, conformable attachment, the device provides an anchoring action via one or more microelectrodes, each having an insertable tip particularly shaped to provide the anchoring action. Furthermore, a base portion of each of the microelectrodes is embedded inside conductive poly-dimethyl siloxane (cPDMS). The cPDMS is contained in a pad that is coupled to a conductive track embedded in the flexible substrate. Embedding of the base portion inside the cPDMS material not only allows the microelectrode to bend in various directions, but also provides good electrical conductivity while eliminating the need for attachment processes using solder or epoxy adhesives.

    Abstract translation: 3D微电极装置包括含有聚二甲基硅氧烷（PDMS）的柔性基材。 该装置可以以适于附着到活体大鼠的腓肠肌外侧的小器官的微型形状来制造。 除了提供小型化，顺应性附件之外，该装置通过一个或多个微电极提供锚定作用，每个微电极具有特别成形以提供锚定作用的可插入尖端。 此外，每个微电极的基底部分嵌入导电性聚二甲基硅氧烷（cPDMS）内部。 cPDMS包含在耦合到嵌入在柔性基板中的导电轨道的焊盘中。 在cPDMS材料内部嵌入基部不仅允许微电极在各个方向上弯曲，而且还提供良好的导电性，同时不需要使用焊料或环氧树脂粘合剂的连接工艺。

    DEVICES, SYSTEMS AND METHODS FOR HIGH-THROUGHPUT ELECTROPHYSIOLOGY
    5.
    发明申请
    DEVICES, SYSTEMS AND METHODS FOR HIGH-THROUGHPUT ELECTROPHYSIOLOGY 有权
    高通量电生理学的设备，系统和方法

    公开(公告)号：US20150301026A1

    公开(公告)日：2015-10-22

    申请号：US14744513

    申请日：2015-06-19

    Applicant: AXION BIOSYSTEMS, INC.

    Inventor： Swaminathan Rajaraman ,  James D Ross ,  Amanda Preyer

    IPC: G01N33/50

    CPC classification number: G01N33/5014 ,  B01L3/5085 ,  B01L2200/025 ,  B01L2300/0645 ,  B01L2300/0829 ,  C12M23/12 ,  G01N33/4836

    Abstract: Electrophysiology culture plates are provided and are formed from a transparent micro-electrode array (MEA) plate. The MEA plate comprises a substrate, a first layer and a first insulating layer. The substrate has a plurality of vias extending from an upper to a lower surface, each via being in electrical contact with each of a plurality of contact pads disposed on the lower surface. The first layer is disposed on the upper surface of the substrate and has a plurality of MEA arrays in in electrical communication with at least a first routing layer. Each MEA array comprises a plurality of reference electrodes and a plurality of microelectrodes and the first routing layer is in electrical communication with a select number of the plurality of vias. A first insulating layer is disposed on the first layer. The MEA plate is joined to a biologic culture plate having a plurality of culture wells such that each culture well defines an interior cavity having a bottom surface that is at least partially transparent and in positioned in registration with a select optical port. The MEA plate is coupled to the biologic culture well plate such that each MEA array is operatively coupled to one culture well wherein each microelectrode and each reference electrode are in electrical communication with the interior cavity through the bottom surface of the culture well.

    Abstract translation: 提供电生理培养板并由透明微电极阵列（MEA）板形成。 MEA板包括基底，第一层和第一绝缘层。 衬底具有从上表面延伸到下表面的多个通孔，每个通孔与设置在下表面上的多个接触焊盘中的每一个电接触。 第一层设置在衬底的上表面上并且具有与至少第一路由层电通信的多个MEA阵列。 每个MEA阵列包括多个参考电极和多个微电极，并且第一路由层与选择数量的多个通孔电连通。 第一绝缘层设置在第一层上。 将MEA板连接到具有多个培养孔的生物培养板，使得每个培养井定义具有至少部分透明的底表面并定位成与选择光学端口对准的内部空腔。 将MEA板耦合到生物培养孔板，使得每个MEA阵列可操作地偶联到一个培养孔，其中每个微电极和每个参比电极通过培养孔的底表面与内腔电连通。

    DEVICES, SYSTEMS, AND METHODS FOR TARGETED PLATING OF MATERIALS IN HIGH-THROUGHPUT CULTURE PLATES
    6.
    发明申请
    DEVICES, SYSTEMS, AND METHODS FOR TARGETED PLATING OF MATERIALS IN HIGH-THROUGHPUT CULTURE PLATES 有权
    用于高精度培养板材料的定向涂层的装置，系统和方法

    公开(公告)号：US20150125942A1

    公开(公告)日：2015-05-07

    申请号：US14533373

    申请日：2014-11-05

    Applicant: AXION BIOSYSTEMS, INC.

    Inventor： Robert Dixon Grier, JR. ,  Anthony Michael Nicolini ,  Colin Michael Arrowood ,  Swaminathan Rajaraman

    IPC: C12M1/00 ,  C12M1/32 ,  G01N33/487

    CPC classification number: C12M23/38 ,  C12M23/00 ,  C12M23/12 ,  C12M33/04 ,  C12M35/02 ,  C12M41/12 ,  C12M41/26 ,  C12M41/32 ,  C12M41/36 ,  C12M41/46 ,  C12M41/48 ,  G01N33/48728

    Abstract: Devices, systems, and methods for facilitating placement of cells and materials in culture plates configured for high-throughput applications are provided. A culture system is provided with a culture plate having a lid for guiding placement of cells and materials in each individual culture well of a culture plate. The lid may provide for coupling to an electrophysiology culture plate comprising a biosensor plate and a biologic culture plate, where the biosensor plate underlies and is coupled to the culture well plate such that each biosensor is operatively coupled to one culture well of the plurality of culture wells. A containment device that physically influences the positioning of fluid received in the culture plate is also provided herein.

    Abstract translation: 提供了用于促进细胞和材料在配置用于高通量应用的培养板中的放置的装置，系统和方法。 培养系统具有培养板，该培养板具有用于引导将细胞和材料放置在培养板的各个培养孔中的盖子。 盖子可以提供与包括生物传感器板和生物培养板的电生理学培养板的耦合，其中生物传感器板位于培养皿板下并且连接到培养皿板，使得每个生物传感器可操作地偶联到多个培养物的一个培养物 井。 本文还提供了物理地影响接收在培养板中的流体定位的容纳装置。

    SYSTEMS AND METHODS FOR ASSESSING DATA COLLECTED FROM AN ELECTRICALLY ACTIVE CELL CULTURE
    7.
    发明申请
    SYSTEMS AND METHODS FOR ASSESSING DATA COLLECTED FROM AN ELECTRICALLY ACTIVE CELL CULTURE 审中-公开

    公开(公告)号：US20180292389A1

    公开(公告)日：2018-10-11

    申请号：US15964139

    申请日：2018-04-27

    Applicant: Axion BioSystems, Inc.

    Inventor： Stacie Ann Chvatal ,  Daniel Christopher Millard ,  James David Ross

    IPC: G01N33/50 ,  H04L29/08 ,  A61B5/04 ,  A61B5/0464

    Abstract: Disclosed herein are systems and methods for assessing electrically active cell cultures. Optionally, the data can be collected using a microelectrode array (MEA). For example, electrically active cells, such as cardiomyocytes, are cultured such that they are in electrical communication with at least a portion of the electrodes of a well of the MEA. The assessments derived from the disclosed methods may be used to reduce the effects of confounding variables in data obtained from an electrically active cell culture. The methods may also be used to determine a quantitative measure of arrhythmia burden. The methods may also be used to decide if a particular culture or set of data is suitable for inclusion in scientific and characterization studies. Also disclosed is a method of finding the global conduction velocity of an electrically active cell culture.

    Cell-based biosensor array and associated methods for manufacturing the same
    8.
    发明授权
    Cell-based biosensor array and associated methods for manufacturing the same 有权

    公开(公告)号：US10067117B2

    公开(公告)日：2018-09-04

    申请号：US14825140

    申请日：2015-08-12

    Applicant: Axion BioSystems, Inc.

    Inventor： Phillip Edward Tyler ,  Swaminathan Rajaraman ,  Amanda Jervis Preyer

    IPC: G01N33/483 ,  B01L3/00

    Abstract: A cell-based biosensor array includes a base plate having a plurality of substantially transparent areas. The cell-based biosensor array also includes a flexible substrate coupled to the base plate and having disposed thereon a plurality of electrode sets, a plurality of terminal contacts, and a plurality of conductive traces. Each electrode set is disposed proximate a respective one of the substantially transparent areas, and each electrode set includes at least one electrode configured to detect an electric signal. Each terminal contact is associated with a respective one of the at least one electrode and disposed proximate a perimeter of the flexible substrate. Each conductive trace is electrically coupling a respective at least one electrode to the corresponding terminal contact. A first portion of flexible substrate including the electrode sets is disposed on a first surface of the base plate. A second portion of the flexible substrate including the terminal contacts is disposed on a second surface of the base plate.

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