公开(公告)号：US20080058924A1

公开(公告)日：2008-03-06

申请号：US11514624

申请日：2006-09-01

申请人： Aaron Ingle ,  Vaso Adzich

发明人： Aaron Ingle ,  Vaso Adzich

IPC分类号： A61F2/24

CPC分类号： A61F2/2448 ,  A61F2002/30199 ,  A61F2230/0063

摘要： A mitral annuloplasty ring that has a saddle shape with an upward bow in both an anterior segment and a posterior portion, with the upward bow being more pronounced in the anterior segment. The ring defines a closed ring body with a rounded isosceles triangular shape and the anterior segment along a long side. The posterior portion bulges outward to create a minor-major axis dimension ratio of between about 3.3:4 to 4:4. An inner ring body is made of a generally rigid material such as titanium that will substantially resist distortion when subjected to the stress imparted thereon after implantation in the mitral valve annulus of an operating human heart. The outward and upward posterior bow of the annuloplasty ring corrects for pathologies associated with mitral valve prolapse, as seen with Barlow's syndrome for instance, in which the leaflets tend to be elongated or floppy. The anterior segment has an enhanced upward bow to conform to systolic mitral annulus shapes, and the upward posterior bow is somewhat lower, for example between 1-2 mm lower, to help reduce the chance of suture pull-out, or dehiscence.

摘要翻译： 二尖瓣环成形术环，其具有在前段和后部中具有向上弓的马鞍形状，其中向上弓在前段更明显。 环限定了具有圆形等腰三角形形状的封闭环体，并且沿长边形成前部。 后部向外凸出以产生约3.3：4至4：4之间的次长轴尺寸比。 内环主体由大致刚性的材料制成，例如钛，其在植入在操作的人心脏的二尖瓣环中之后受到施加于其上的应力时将基本上抵抗变形。 瓣膜成形术环的向外和向后的后弓修正与二尖瓣脱垂相关的病变，如Barlow综合征所见，其中小叶倾向于伸长或软化。 前段具有增强的向上弓，以符合收缩期二尖瓣环形状，并且向上后弓稍低，例如在1-2mm以下之间，以帮助减少缝合线拔出或开裂的机会。

公开(公告)号：US20070156234A1

公开(公告)日：2007-07-05

申请号：US11515466

申请日：2006-09-01

申请人： Vaso Adzich ,  Aaron Ingle ,  Matthew Winston

发明人： Vaso Adzich ,  Aaron Ingle ,  Matthew Winston

IPC分类号： A61F2/24

CPC分类号： A61F2/2445 ,  A61B2017/00243 ,  A61F2/2448 ,  A61F2/2466

摘要： An annuloplasty ring and ring holder combination includes a generally triangular-shaped ring and a generally T-shaped holder. The ring holder has a base portion forming the top of the T shape and engaging against a first segment of the ring, with a radial arm extending from the base portion and forming the post of the T. The radial arm engages against a junction between two segments of the ring. The invention includes placements of suture holes and cutting wells which, in combination with the improved ring holder shape, afford the user improved access and visibility to the surgical site, the ring, and to the suture that is used to retain the annuloplasty ring to the holder.

摘要翻译： 环形成形术环和环保持器组合包括大致三角形的环和大致T形的保持器。 环形支架具有形成T形的顶部的基部，并且与基部的第一部分接合，其中径向臂从基部延伸并形成T的柱。径向臂接合两个 环的段。 本发明包括缝合孔和切割井的布置，其与改进的环保持器形状相结合，使得使用者改进了对手术部位，环以及用于将瓣环成形术环保持在缝合处的缝合线的可见性。 持有人

公开(公告)号：US07842085B2

公开(公告)日：2010-11-30

申请号：US11515466

申请日：2006-09-01

申请人： Vaso Adzich ,  Aaron Ingle ,  Matthew Winston

发明人： Vaso Adzich ,  Aaron Ingle ,  Matthew Winston

IPC分类号： A61F2/24

CPC分类号： A61F2/2445 ,  A61B2017/00243 ,  A61F2/2448 ,  A61F2/2466

摘要： An annuloplasty ring and ring holder combination includes a generally triangular-shaped ring and a generally T-shaped holder. The ring holder has a base portion forming the top of the T shape and engaging against a first segment of the ring, with a radial arm extending from the base portion and forming the post of the T. The radial arm engages against a junction between two segments of the ring. The invention includes placements of suture holes and cutting wells which, in combination with the improved ring holder shape, afford the user improved access and visibility to the surgical site, the ring, and to the suture that is used to retain the annuloplasty ring to the holder.

摘要翻译： 环形成形术环和环保持器组合包括大致三角形的环和大致T形的保持器。 环形支架具有形成T形的顶部的基部，并且与基部的第一部分接合，其中径向臂从基部延伸并形成T的柱。径向臂接合两个 环的段。 本发明包括缝合孔和切割井的布置，其与改进的环保持器形状相结合，使得使用者改进了对手术部位，环以及用于将瓣环成形术环保持在缝合处的缝合线的可见性。 持有人

公开(公告)号：US08685083B2

公开(公告)日：2014-04-01

申请号：US11474740

申请日：2006-06-26

申请人： Patrick Perier ,  Vaso Adzich

发明人： Patrick Perier ,  Vaso Adzich

IPC分类号： A61F2/24

CPC分类号： A61B17/02 ,  A61B17/0469 ,  A61B2017/00243 ,  A61B2017/06057 ,  A61F2/2457 ,  A61F2/2466

摘要： The invention is an apparatus, system, and method for repairing heart valves. A suture line is secured to a papillary muscle, and then passed through a portion of a heart valve leaflet. A reference element is provided at a desired distance from a plane defined by the heart valve annulus. The suture line is secured to the heart valve leaflet at a position adjacent the reference element. The reference element may part of a device configured for placement on or in a heart valve annulus. The reference element may be slidingly secured to the device so that the distance of the reference element from the main body of the device can be varied by a surgeon or other user. The reference element may be a line of suture, which may be pre-installed during manufacture of the device or may be installed by the surgeon or other user.

摘要翻译： 本发明是用于修复心脏瓣膜的装置，系统和方法。 缝合线固定到乳头肌，然后穿过心脏瓣膜小叶的一部分。 参考元件设置在距离由心脏瓣膜环定义的平面所需的距离处。 缝合线在与参考元件相邻的位置处固定到心脏瓣膜小叶上。 参考元件可以被配置为放置在心脏瓣膜环上或心脏瓣膜环中的装置的一部分。 参考元件可以滑动地固定到设备，使得参考元件与设备的主体的距离可以由外科医生或其他用户改变。 参考元件可以是缝合线，其可以在装置的制造期间预先安装，或者可由外科医生或其他用户安装。

公开(公告)号：US20110224786A1

公开(公告)日：2011-09-15

申请号：US13111820

申请日：2011-05-19

申请人： Alain F. Carpentier ,  David H. Adams ,  Vaso Adzich

发明人： Alain F. Carpentier ,  David H. Adams ,  Vaso Adzich

IPC分类号： A61F2/24 ,  B23P17/04

CPC分类号： A61F2/2448 ,  A61F2/24 ,  A61F2/2409 ,  A61F2/2445 ,  A61F2230/0034 ,  A61F2230/0065 ,  A61F2250/0018 ,  A61F2250/0037 ,  Y10T29/49

摘要： Annuloplasty rings optimally sized to take into account more of the common degenerative valve pathologies. Each ring has a structural ring body with a shape that complies with predicted shapes of degenerative valvular diseases, such as fibroelastic deficiency (FED), Marfan's or Barlow's. The predicted shapes are obtained through careful echocardiographic and intraoperative measurements, and often differ for different annulus orifice sizes. For instance, in mitral rings the larger rings have larger minor axis and oblique axis dimensions relative to their major axis dimensions, and are more circular as opposed to D-shaped. The rings may also be three-dimensional and the relative heights around the rings may change for different sized rings. A mitral ring may have a higher anterior saddle relative to a posterior saddle, with the relative heights varying across the ring sizes. The ring may have varying flexibility around the ring periphery which also changes for different ring sizes. A bulge on the sewing cuff forms a step on the outflow side for ease of suturing, which may be indicated by a suture line.

摘要翻译： 瓣膜成形术环最优化以考虑更多的常见的退行性瓣膜病变。 每个环具有结构环体，其形状符合退化性瓣膜疾病的预测形状，例如纤维弹性不足（FED），Marfan's或Barlow's。 通过仔细的超声心动图和术中测量获得预测的形状，并且对于不同的环形孔尺寸通常是不同的。 例如，在二尖瓣环中，较大的环相对于其长轴尺寸具有较大的短轴和倾斜轴尺寸，并且与D形相反更圆。 环也可以是三维的，并且围绕环的相对高度可以针对不同尺寸的环而改变。 二尖瓣环可能具有相对于后鞍座的较高的前鞍座，相对高度在环尺寸之间变化。 环可能围绕环周围具有不同的柔性，这也适用于不同的环尺寸。 缝合套管上的凸起在流出侧形成一个便于缝合的步骤，这可以由缝合线表示。

公开(公告)号：US20090093877A1

公开(公告)日：2009-04-09

申请号：US12206604

申请日：2008-09-08

申请人： Yaron Keidar ,  Vaso Adzich ,  Dan Rottenberg ,  Boaz Manash ,  Alon Nahshon

发明人： Yaron Keidar ,  Vaso Adzich ,  Dan Rottenberg ,  Boaz Manash ,  Alon Nahshon

IPC分类号： A61F2/24

CPC分类号： A61F2/2466 ,  A61F2/2427 ,  A61F2/2448

摘要： An active annuloplasty ring holder having a template that can be folded or pivoted to the side allowing the template to align longitudinally with the handle and enter the patient's chest through a small incision. The holder may include a mechanism to remotely detach sutures fastening the ring to the holder, thereby detaching the ring while avoiding the risk associated with introducing a scalpel into the operating field. A detachment mechanism may include a movable pin actuated by a pull wire that releases a plurality of holding sutures, or a hot wire, knives, or pull wire that severs the sutures. The holder may have a built-in light source for better visualization of the ring inside the heart. The holder may also have an optical means of visualizing the inside of the heart from the proximal end of the handle.

摘要翻译： 活动的瓣膜成形术环形支架具有可以折叠或枢转到侧面的模板，允许模板与手柄纵向对准并通过小切口进入患者的胸部。 保持器可以包括用于将紧固环的缝合线远程地分离到保持器的机构，从而分离环，同时避免与将手术刀引入操作区域相关联的风险。 脱离机构可以包括由释放多个保持缝合线的拉线致动的可动销，或者切断缝线的热丝，刀或拉丝。 保持器可以具有内置的光源，用于更好地可视化心脏内的环。 保持器还可以具有从手柄的近端可视化心脏内部的光学装置。

公开(公告)号：US08734526B2

公开(公告)日：2014-05-27

申请号：US13302134

申请日：2011-11-22

申请人： Vaso Adzich ,  Stephen Graham Bell ,  Giuseppe Amato

发明人： Vaso Adzich ,  Stephen Graham Bell ,  Giuseppe Amato

IPC分类号： A61F2/02

CPC分类号： A61F2/0063

摘要： A mesh to repair a hole in a muscle wall includes a resilient mesh body and fortifying structure such as mesh portions of thicker weave than other portions, or strengthening members that can be engaged with the mesh and then removed from the mesh once the mesh is placed over the hole. The same principles can be applied to a plug that is engaged with the mesh for filling the hole.

摘要翻译： 用于修复肌肉壁中的孔的网眼包括弹性网状体和强化结构，例如比其他部分更厚的织物的网状部分，或者可以与网状物接合，然后一旦放置网状物从网状物中移除， 在洞上 相同的原理可以应用于与网孔接合以填充孔的插塞。

公开(公告)号：US20120215304A1

公开(公告)日：2012-08-23

申请号：US13422706

申请日：2012-03-16

申请人： Alain F. Carpentier ,  David H. Adams ,  Vaso Adzich

发明人： Alain F. Carpentier ,  David H. Adams ,  Vaso Adzich

IPC分类号： A61F2/24

CPC分类号： A61F2/2448 ,  A61F2/24 ,  A61F2/2409 ,  A61F2/2445 ,  A61F2230/0034 ,  A61F2230/0065 ,  A61F2250/0018 ,  A61F2250/0037 ,  Y10T29/49

摘要： Annuloplasty rings optimally sized to take into account more of the common degenerative valve pathologies. Each ring has a structural ring body with a shape that complies with predicted shapes of degenerative valvular diseases. The predicted shapes are obtained through careful echocardiographic and intraoperative measurements, and often differ for different annulus orifice sizes. For instance, in mitral rings the larger rings have larger minor axis and oblique axis dimensions relative to their major axis dimensions, and are more circular as opposed to D-shaped. The rings may also be three-dimensional and the relative heights around the rings may change for different sized rings. A mitral ring may have a higher anterior saddle relative to a posterior saddle, with the relative heights varying across the ring sizes. The ring may have varying flexibility around the ring periphery which also changes for different ring sizes.

摘要翻译： 瓣膜成形术环最优化以考虑更多的常见的退行性瓣膜病变。 每个环具有结构环体，其形状符合退化性瓣膜疾病的预测形状。 通过仔细的超声心动图和术中测量获得预测的形状，并且对于不同的环形孔尺寸通常是不同的。 例如，在二尖瓣环中，较大的环相对于其长轴尺寸具有较大的短轴和倾斜轴尺寸，并且与D形相反更圆。 环也可以是三维的，并且围绕环的相对高度可以针对不同尺寸的环而改变。 二尖瓣环可能具有相对于后鞍座的较高的前鞍座，相对高度在环尺寸之间变化。 环可能围绕环周围具有不同的柔性，这也适用于不同的环尺寸。

公开(公告)号：US20120053602A1

公开(公告)日：2012-03-01

申请号：US13291535

申请日：2011-11-08

申请人： Vaso Adzich ,  Stephen Graham Bell ,  Giuseppe Amato

发明人： Vaso Adzich ,  Stephen Graham Bell ,  Giuseppe Amato

IPC分类号： A61F13/36 ,  A61B17/08

CPC分类号： A61F2/0063

摘要： A mesh to repair a hole in a muscle wall includes a resilient mesh body and fortifying structure such as mesh portions of thicker weave than other portions, or strengthening members that can be engaged with the mesh and then removed from the mesh once the mesh is place over the hole. The same principles can be applied to a plug that is engaged with the mesh for filling the hole.

摘要翻译： 用于修复肌肉壁中的孔的网格包括弹性网状体和强化结构，例如比其他部分更厚的织物的网状部分，或者可以与网状物接合，然后一旦网格放置，则从网状物中移除的加强构件 在洞上 相同的原理可以应用于与网孔接合以填充孔的插塞。

公开(公告)号：US20090192530A1

公开(公告)日：2009-07-30

申请号：US12361148

申请日：2009-01-28

申请人： Vaso Adzich ,  Stephen Graham Bell ,  Giuseppe Amato

发明人： Vaso Adzich ,  Stephen Graham Bell ,  Giuseppe Amato

IPC分类号： A61B17/03

CPC分类号： A61F2/0063

摘要： A mesh to repair a hole in a muscle wall includes a resilient mesh body and fortifying structure such as mesh portions of thicker weave than other portions, or strengthening members that can be engaged with the mesh and then removed from the mesh once the mesh is place over the hole. The same principles can be applied to a plug that is engaged with the mesh for filling the hole.

摘要翻译： 用于修复肌肉壁中的孔的网格包括弹性网状体和强化结构，例如比其他部分更厚的织物的网状部分，或者可以与网状物接合，然后一旦网格放置，则从网状物中移除的加强构件 在洞上 相同的原理可以应用于与网孔接合以填充孔的插塞。