公开(公告)号：US08530512B2

公开(公告)日：2013-09-10

申请号：US12973078

申请日：2010-12-20

申请人： Aaron P. Monte ,  M. Shahjahan Kabir ,  Marc A. Rott ,  William R. Schwan ,  James M. Cook, III ,  Jennifer A. Miskowski ,  Ranjit Verma ,  Leah Defoe

发明人： Aaron P. Monte ,  M. Shahjahan Kabir ,  Marc A. Rott ,  William R. Schwan ,  James M. Cook, III ,  Jennifer A. Miskowski ,  Ranjit Verma ,  Leah Defoe

IPC分类号： A61K31/38 ,  A61K31/34 ,  A61K31/404

CPC分类号： C07D213/30 ,  A61K31/085 ,  A61K31/381 ,  A61K36/185 ,  C07C43/23 ,  C07D213/64 ,  C07D213/65 ,  C07D213/68 ,  C07D333/16 ,  C07D333/56 ,  C07D333/62 ,  C07D333/64

摘要： The present invention provides compounds and methods of using of the compounds as anti-infective and anthelminitc agents. In a preferred embodiment, the present invention provides the following compound of Formula III: wherein: R1 is not H when R2 is H and R2 is not H when R1 is H, further wherein R1 is OH or CH(2n+1)O, wherein n is 1-10; R2 is OH or CH(2n+1)O, where n is 1-10; W is alkyl, phenyl, halophenyl, pyridyl, piperidyl, or a substituted or unsubstituted aryl group, including unsubstituted and substituted aromatic heterocycles; and L is an optional linker or linking group selected from O, S, NH, CF2, or CH2, and x=0 or 1, i.e., if x=0, no linking group is present and when x=0, W is not phenyl.

摘要翻译： 本发明提供了化合物和使用该化合物作为抗感染和抗栓剂的方法。 在优选的实施方案中，本发明提供以下式III化合物：其中：当R 1为H时，R 1不为H，且R 1为H时R 2不为H，此外，R 1为OH或CH（2n + 1）O， 其中n为1-10; R2是OH或CH（2n + 1）O，其中n是1-10; W是烷基，苯基，卤代苯基，吡啶基，哌啶基或取代或未取代的芳基，包括未取代和取代的芳族杂环; 并且L是选自O，S，NH，CF 2或CH 2，x = 0或1的任选的接头或连接基团，即，如果x = 0，则不存在连接基团，并且当x = 0时，W不是 苯基。

公开(公告)号：US20110092578A1

公开(公告)日：2011-04-21

申请号：US12973078

申请日：2010-12-20

申请人： Aaron P. Monte ,  M. Shahjahan Kabir ,  Marc A. Rott ,  William R. Schwan ,  James M. Cook, III ,  Jennifer A. Miskowski

发明人： Aaron P. Monte ,  M. Shahjahan Kabir ,  Marc A. Rott ,  William R. Schwan ,  James M. Cook, III ,  Jennifer A. Miskowski

IPC分类号： A61K31/381 ,  C07D333/56 ,  C07D333/64 ,  C07D333/62 ,  C07D333/16 ,  C07C43/23 ,  C07C323/18 ,  C07C323/16 ,  A61K31/085 ,  A61K31/10 ,  A01N43/12 ,  A01N43/10 ,  A01N31/14 ,  A01N31/08 ,  A61P31/00 ,  A61P31/04 ,  A61P33/10 ,  A01P5/00 ,  A01P1/00

CPC分类号： C07D213/30 ,  A61K31/085 ,  A61K31/381 ,  A61K36/185 ,  C07C43/23 ,  C07D213/64 ,  C07D213/65 ,  C07D213/68 ,  C07D333/16 ,  C07D333/56 ,  C07D333/62 ,  C07D333/64

摘要： The present invention provides compounds and methods of using of the compounds as anti-infective and anthelminitc agents. In a preferred embodiment, the present invention provides the following compound of Formula III: wherein: R1 is not H when R2 is H and R2 is not H when R1 is H, further wherein R1 is OH or CH(2n+1)O, wherein n is 1-10; R2 is OH or CH(2n+1)O, where n is 1-10; W is alkyl, phenyl, halophenyl, pyridyl, piperidyl, or a substituted or unsubstituted aryl group, including unsubstituted and substituted aromatic heterocycles; and L is an optional linker or linking group selected from O, S, NH, CF2, or CH2, and x=0 or 1, i.e., if x=0, no linking group is present.

摘要翻译： 本发明提供了化合物和使用该化合物作为抗感染和抗栓剂的方法。 在优选的实施方案中，本发明提供以下式III化合物：其中：当R 1为H时，R 1不为H，且R 1为H时R 2不为H，此外，R 1为OH或CH（2n + 1）O， 其中n为1-10; R2是OH或CH（2n + 1）O，其中n是1-10; W是烷基，苯基，卤代苯基，吡啶基，哌啶基或取代或未取代的芳基，包括未取代和取代的芳族杂环; 并且L是选自O，S，NH，CF 2或CH 2，x = 0或1的任选的接头或连接基团，即如果x = 0，则不存在连接基团。

公开(公告)号：US3948190A

公开(公告)日：1976-04-06

申请号：US512140

申请日：1974-10-04

申请人： James M. Cook, III ,  Edward K. Tazzia

发明人： James M. Cook, III ,  Edward K. Tazzia

IPC分类号： B65D19/00 ,  B65D19/44 ,  B65D19/24

CPC分类号： B65D19/004 ,  B65D19/44 ,  B65D2519/00034 ,  B65D2519/00069 ,  B65D2519/00268 ,  B65D2519/00288 ,  B65D2519/00318 ,  B65D2519/00333 ,  B65D2519/00338 ,  B65D2519/00407 ,  B65D2519/0094

摘要： An industrial load-carrying pallet comprising an integral sheet of material formed with strengthening ribs extending thereacross, three centrally disposed pedestals extending downwardly at the center line and generally W-shaped pedestals disposed adjacent the side extremities. Grooves extend downwardly from the upper surface and are disposed along the circumference of four circles for receiving the bottom rims of four drums. The pedestals have recesses therein disposed on the circumference of four circles whereby the pedestals may rest upon and engage the top rims of four drums. The area of the top surface within each circle for receiving the bottom rim of a drum is spherically concave. The side pedestals have spaced converging walls in a downward direction which are joined at the lower extremities by a bottom base. Empty pallets may be stacked by placing the pedestals within one another. However, there is included anti-locking means in the form of shoulders extending inwardly from the side walls of the side pedestals to engage bottom base of a like pedestal of another pallet to prevent stacked pallets from being wedged into binding engagement with one another.

摘要翻译： 一种工业承载托盘，其包括整体的材料片材，其形成有在其上延伸的加强肋，在中心线向下延伸的三个中心布置的基座以及邻近所述侧端布置的大体上为W形的基座。 槽从上表面向下延伸，并且沿着四个圆的圆周设置以接收四个鼓的底部边缘。 基座在四个圆周的圆周上具有凹槽，由此基座可以搁置在四个滚筒的顶部边缘上并与其接合。 用于接收鼓的底部边缘的每个圆中的顶部表面的面积是球形的。 侧基座具有向下方向的间隔的会聚壁，其在下端通过底部底座连接。 可以通过将基座放置在彼此中来堆叠空托盘。 然而，包括从侧座的侧壁向内延伸的肩部形式的防抱死装置，以接合另一个托盘的类似基座的底部基座，以防止堆叠的托盘楔入彼此的结合接合。

公开(公告)号：US4254873A

公开(公告)日：1981-03-10

申请号：US943436

申请日：1978-09-18

申请人： James M. Cook, III ,  Dennis M. Foy ,  Lyle H. Shuert

发明人： James M. Cook, III ,  Dennis M. Foy ,  Lyle H. Shuert

IPC分类号： B65D19/00

CPC分类号： B65D19/00

摘要： A pallet system including two embodiments of a pallet having a deck including four sides and providing a load-supporting surface. A plurality of spaced hollow legs project from the opposite side of the deck and a plurality of hollow reinforcing ribs project from the opposite surface to define channels in the load-supporting surface. A hollow ridge projects from the opposite surface and extends along the sides at the periphery of the deck to define a groove in the load-supporting surface for receiving the bottom edge of a wall. There is at least one transverse rib projecting from the opposite surface and extending between opposite sides of the deck to define a transverse groove in the load-supporting surface for receiving the bottom edge of a transverse wall whereby walls may extend upwardly from the deck to divide and separate the load-supporting surface into discrete areas. The channels defined by the reinforcing ribs have a larger dimension than do the grooves defined by the ridges for receiving the edges of walls. The reinforcing ribs include a first plurality of ribs extending between corner legs and parallel to opposite sides with a second plurality of ribs extending perpendicular to the first plurality of ribs and having ends terminating short of the first plurality of ribs so as to be spaced therefrom.

摘要翻译： 一种托盘系统，包括托盘的两个实施例，该托盘具有包括四个侧面并且提供承载表面的甲板。 多个间隔开的中空腿从甲板的相对侧突出，并且多个中空的加强肋从相对的表面伸出以限定负载支撑表面中的通道。 中空的脊从相对的表面突出并且沿着甲板的周边的侧面延伸，以在负载支撑表面中限定一个用于接收壁的底部边缘的凹槽。 至少有一个横向肋条从相对表面突出并在甲板的相对侧面之间延伸，以在承载支承表面中限定横向槽，用于接收横向壁的底部边缘，从而壁可以从甲板向上延伸以分开 并将负载支撑表面分离成离散区域。 由加强筋限定的通道具有比用于接收壁边缘的脊限定的凹槽更大的尺寸。 所述加强肋包括在拐角腿之间延伸并且平行于相对侧的第一多个肋，所述第二多个肋具有垂直于所述第一多个肋延伸的第二多个肋，并且具有不超过所述第一多个肋的端部，以便与其间隔开。