公开(公告)号：US20180291029A1

公开(公告)日：2018-10-11

申请号：US15806104

申请日：2017-11-07

Applicant: AbbVie Inc.

Inventor： Neil WISHART ,  Maria A. Argiriadi ,  David J. Calderwood ,  Anna M. Ericsson ,  Bryan R. Fiamengo ,  Kristine E. Frank ,  Michael M. Friedman ,  Dawn M. George ,  Eric R. Goedken ,  Nathan S. Josephsohn ,  Biqin C. Li ,  Michael J. Morytko ,  Kent D. Stewart ,  Jeffrey W. Voss ,  Grier A. Wallace ,  Lu Wang ,  Kevin R. Woller

IPC: C07D487/14 ,  C07D513/14 ,  C07D498/14

Abstract: The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

公开(公告)号：US20160326181A1

公开(公告)日：2016-11-10

申请号：US15152823

申请日：2016-05-12

Applicant: AbbVie Inc.

Inventor： Neil Wishart ,  Maria A. Argiriadi ,  David J. Calderwood ,  Anna M. Ericsson ,  Bryan R. Fiamengo ,  Kristine E. Frank ,  Michael M. Friedman ,  Dawn M. George ,  Eric R. Goedken ,  Nathan S. Josephsohn ,  Biqin C. Li ,  Michael J. Morytko ,  Kent D. Stewart ,  Jeffrey W. Voss ,  Grier A. Wallace ,  Lu Wang ,  Kevin R. Woller

IPC: C07D487/14

CPC classification number: C07D487/14 ,  C07D498/14 ,  C07D513/14

Abstract: The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract translation: 药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。

公开(公告)号：US08642776B2

公开(公告)日：2014-02-04

申请号：US13627753

申请日：2012-09-26

Applicant: AbbVie Inc.

Inventor： Yujia Dai ,  Steven K. Davidsen ,  Anna M. Ericsson ,  Kresna Hartandi ,  Zhiqin Ji ,  Michael R. Michaelides

IPC: C07D275/04

CPC classification number: C07D231/56 ,  C07D261/20 ,  C07D275/04 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D409/04 ,  C07D409/10 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract translation: 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。

公开(公告)号：US09365579B2

公开(公告)日：2016-06-14

申请号：US14610119

申请日：2015-01-30

Applicant: AbbVie Inc.

Inventor： Neil Wishart ,  Maria A. Argiriadi ,  David J. Calderwood ,  Anna M. Ericsson ,  Bryan A. Fiamengo ,  Kristine E. Frank ,  Michael M. Friedman ,  Dawn M. George ,  Eric R. Goedken ,  Nathan S. Josephsohn ,  Biqin C. Li ,  Michael J. Morytko ,  Kent D. Stewart ,  Jeffrey W. Voss ,  Grier A. Wallace ,  Lu Wang ,  Kevin R. Woller

IPC: C07D487/14 ,  C07D498/14 ,  C07D513/14

CPC classification number: C07D487/14 ,  C07D498/14 ,  C07D513/14

Abstract: The invention provide a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomer and isomer thereof wherein the variable are defined herein. The compound of the invention are useful for treating immunological and oncological conditions.

Abstract translation: 本发明提供式（I）化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫和肿瘤病症。

公开(公告)号：US20230082167A1

公开(公告)日：2023-03-16

申请号：US17575731

申请日：2022-01-14

Applicant: AbbVie Inc.

Inventor： Neil WISHART ,  Maria A. ARGIRIADI ,  David J. CALDERWOOD ,  Anna M. Ericsson ,  Bryan A. FIAMENGO ,  Kristine E. FRANK ,  Michael M. FRIEDMAN ,  Dawn M. GEORGE ,  Eric R. GOEDKEN ,  Nathan S. JOSEPHSOHN ,  Biqin C. LI ,  Michael J. MORYTKO ,  Kent D. STEWART ,  Jeffrey W. VOSS ,  Grier A. WALLACE ,  Lu WANG ,  Kevin R. WOLLER

IPC: C07D487/14 ,  C07D498/14 ,  C07D513/14

Abstract: The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

公开(公告)号：US20160222020A1

公开(公告)日：2016-08-04

申请号：US15017802

申请日：2016-02-08

Applicant: AbbVie Inc.

Inventor： Neil Wishart ,  Maria A. Argiriadi ,  David J. Calderwood ,  Anna M. Ericsson ,  Bryan A. Fiamengo ,  Kristine E. Frank ,  Michael M. Friedman ,  Dawn M. George ,  Eric R. Goedken ,  Nathan S. Josephsohn ,  Biqin C. Li ,  Michael J. Morytko ,  Kent D. Stewart ,  Jeffrey W. Voss ,  Grier A. Wallace ,  Lu Wang ,  Kevin R. Woller

IPC: C07D487/14 ,  A61K31/437 ,  C07D471/14 ,  A61K31/4985 ,  A61K45/06

CPC classification number: C07D487/14 ,  A61K31/437 ,  A61K31/4985 ,  A61K45/06 ,  C07D471/14 ,  C07D498/14 ,  C07D513/14

Abstract: The invention provides compounds of Formula (I) and Formula (II) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

公开(公告)号：US20150210708A1

公开(公告)日：2015-07-30

申请号：US14610119

申请日：2015-01-30

Applicant: AbbVie Inc.

Inventor： Neil Wishart ,  Maria A. Argiriadi ,  David J. Calderwood ,  Anna M. Ericsson ,  Bryan A. Fiamengo ,  Kristine E. Frank ,  Michael M. Friedman ,  Dawn M. George ,  Eric R. Goedken ,  Nathan S. Josephsohn ,  Biqin C. Li ,  Michael J. Morytko ,  Kent D. Stewart ,  Jeffrey W. Voss ,  Grier A. Wallace ,  Lu Wang ,  Kevin R. Woller

IPC: C07D487/14

CPC classification number: C07D487/14 ,  C07D498/14 ,  C07D513/14

Abstract: The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract translation: 本发明提供式（I）化合物的药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。

公开(公告)号：US08940778B2

公开(公告)日：2015-01-27

申请号：US13886448

申请日：2013-05-03

Applicant: AbbVie Inc.

Inventor： Yujia Dai ,  Steven K Davidsen ,  Anna M. Ericsson ,  Kresna Hartandi ,  Zhiqin Ji ,  Michael R. Michaelides

IPC: C07D291/00 ,  C07D409/10 ,  C07D409/04 ,  C07D401/12 ,  C07D261/20 ,  C07D409/12 ,  C07D403/12 ,  C07D409/14 ,  C07D275/04 ,  C07D401/04 ,  C07D401/10 ,  C07D413/12 ,  C07D403/14 ,  C07D231/56

CPC classification number: C07D231/56 ,  C07D261/20 ,  C07D275/04 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D409/04 ,  C07D409/10 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.