公开(公告)号：US20220289858A1

公开(公告)日：2022-09-15

申请号：US17496476

申请日：2021-10-07

Applicant: AbbVie Inc.

Inventor： Lorenzo Benatuil ,  Maria A. Argiriadi ,  Bradford L. Mcrae ,  Chung-Ming Hsieh ,  David A. Egan ,  John E. Harlan ,  Russell A. Judge ,  Rui Wang ,  Gillian A. Kingsbury

IPC: C07K16/28 ,  G01N33/566

Abstract: The present invention encompasses antagonist anti-CD40 antibodies and antigen-binding portions thereof. Specifically, the invention relates to humanized anti-CD40 antibodies. In certain embodiments, antibodies of the invention neutralize human CD40 (hCD40) activity. Antibodies, or antibody portions, of the invention are useful for detecting CD40 and for inhibiting CD40 activity, e.g., in a human subject suffering from a disorder in which CD40 activity is detrimental.

公开(公告)号：US20160319026A1

公开(公告)日：2016-11-03

申请号：US15091468

申请日：2016-04-05

Applicant: AbbVie Inc.

Inventor： Tariq Ghayur ,  Junjian Liu ,  Gillian A. Kingsbury ,  Edward B. Reilly ,  Susan E. Morgan-Lappe ,  Jijie Gu

IPC: C07K16/28 ,  G01N33/74 ,  A61K39/395 ,  A61K47/48 ,  A61K45/06

CPC classification number: C07K16/2863 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6879 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/28 ,  C07K16/2809 ,  C07K16/40 ,  C07K16/468 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  G01N33/74 ,  G01N2333/71 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：US20150104452A1

公开(公告)日：2015-04-16

申请号：US14301305

申请日：2014-06-10

Applicant: AbbVie Inc.

Inventor： Tariq Ghayur ,  Edward B. Reilly ,  Andrew Phillips ,  Randy L. Bell ,  Yingchun Li ,  Hua Ying ,  Susan E. Morgan-Lappe ,  Gillian A. Kingsbury ,  Jieyi Wang ,  Suzanne M. Norvell ,  Junjian Liu

IPC: C07K16/46 ,  A61K45/06 ,  G01N33/68 ,  C07K16/28 ,  G01N33/74 ,  A61K39/395 ,  C07K16/22

CPC classification number: C07K16/468 ,  A61K39/39533 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  G01N33/6872 ,  G01N33/74 ,  G01N2333/515 ,  G01N2333/705 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/58 ,  Y10S435/81

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.