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公开(公告)号:US20140287992A1
公开(公告)日:2014-09-25
申请号:US14299095
申请日:2014-06-09
Applicant: Enanta Pharmaceuticals, Inc. , AbbVie, Inc.
Inventor: Hui-Ju Chen , Keith F. McDaniel , Brian E. Green , Jason P. Shanley , Albert W. Kruger , Jorge Gandarilla , Dennie S. Welch , Russell D. Cink , Steven C. Cullen , Yonghua Gai , Guoqiang Wang , Yat Sun Or
IPC: C07K5/083
CPC classification number: C07K5/081 , C07D487/04
Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
Abstract translation: 本发明涉及新的大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐,酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。
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公开(公告)号:US20130303547A1
公开(公告)日:2013-11-14
申请号:US13944447
申请日:2013-07-17
Applicant: AbbVie Inc.
Inventor: Brian E. Green , David D. Anderson , Todd D. Bosse , Curt S. Cooper , Larry L. Klein , Allan C. Krueger , Daniel P. Larson , Dachun Liu , Keith F. McDaniel , Christopher E. Motter , John K. Pratt , Todd W. Rockway , Teresa A. Rosenberg , Ming C. Yeung , Hui-Ju Chen , Jason P. Shanley
IPC: C07D403/12 , C07D409/14 , C07D403/14 , C07D207/16 , C07D241/24
CPC classification number: C07D403/12 , C07D207/16 , C07D241/24 , C07D403/14 , C07D409/14 , C07K7/02
Abstract: This invention relates to: (a) compounds of formula I and salts thereof that, inter alia, are useful as hepatitis C virus (HCV) inhibitors; (b) intermediates useful for the preparation of such compounds and salts; (c) pharmaceutical compositions comprising such compounds and salts; and (d) methods of use of such compounds, salts, and compositions.
Abstract translation: 本发明涉及:(a)式I化合物及其盐,其特别可用作丙型肝炎病毒(HCV)抑制剂; (b)可用于制备这些化合物和盐的中间体; (c)包含这些化合物和盐的药物组合物; 和(d)使用这些化合物,盐和组合物的方法。
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公开(公告)号:US09493506B2
公开(公告)日:2016-11-15
申请号:US14299095
申请日:2014-06-09
Applicant: Enanta Pharmaceuticals, Inc. , AbbVie, Inc.
Inventor: Hui-Ju Chen , Keith F. McDaniel , Brian E. Green , Jason P. Shanley , Albert W. Kruger , Jorge Gandarilla , Dennie S. Welch , Russell D. Cink , Steven C. Cullen , Yonghua Gai , Guoqiang Wang , Yat Sun Or
IPC: C07D487/04 , C07K5/083
CPC classification number: C07K5/081 , C07D487/04
Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
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公开(公告)号:US09309279B2
公开(公告)日:2016-04-12
申请号:US14170199
申请日:2014-01-31
Applicant: AbbVie, Inc. , Enanta Pharmaceuticals, Inc.
Inventor: Yiyin Ku , Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , Dale J. Kempf , David J. Grampovnik , Ying Sun , Dong Liu , Yonghua Gai , Yat Sun Or , Seble H. Wagaw , Kenneth Engstrom , Tim Grieme , Ahmad Sheikh , Jianzhang Mei
IPC: C07K1/113 , C07D487/04
CPC classification number: C07K1/113 , C07D487/04
Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
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公开(公告)号:US20140148573A1
公开(公告)日:2014-05-29
申请号:US14170199
申请日:2014-01-31
Applicant: Enanta Pharmaceuticals, Inc. , AbbVie, Inc.
Inventor: Yiyin Ku , Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , Dale J. Kempf , David J. Grampovnik , Ying Sun , Dong Liu , Yonghua Gai , Yat Sun Or , Seble H. Wagaw , Kenneth Engstrom , Tim Grieme , Ahmad Sheikh , Jianzhang Mei
IPC: C07K1/113
CPC classification number: C07K1/113 , C07D487/04
Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
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