公开(公告)号：US09796708B2

公开(公告)日：2017-10-24

申请号：US14780018

申请日：2014-03-13

申请人： AbbVie Inc.

发明人： Yunsong Tong ,  Milan Bruncko ,  Richard F. Clark ,  Michael Curtin ,  Alan S. Florjancic ,  Robin R. Frey ,  Jianchun Gong ,  Todd M. Hansen ,  Zhiqin Ji ,  Chunqiu Lai ,  Anthony Mastracchio ,  Michael Michaelides ,  Juliem Miyashiro ,  Roberto M. Risi ,  Xiaohong Song ,  Zhi-fu Tao ,  Keith W. Woods ,  Guidong Zhu ,  Thomas Penning ,  Andrew Souers ,  Rajeev Goswami ,  Omprakash Reddy Iguturi ,  Madhu Babu Dabbeeru

IPC分类号： C07D401/02 ,  C07D401/10 ,  A61K31/437 ,  A61K31/4353 ,  C07D471/04 ,  A61K45/06 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/5377

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/5377 ,  A61K45/06 ,  A61K2300/00

摘要： Disclosed are compounds of Formula (IIa), wherein R1, R2, R3A, R3B, R3C, R3D, R3E, and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (IIa).