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公开(公告)号：US20130303511A1
公开(公告)日：2013-11-14
申请号：US13891366
申请日：2013-05-10
Applicant: AbbVie Inc.
Inventor： Richard F. Clark , Bryan Sorensen , Augustine T. Osuma , Robin Frey , Kenton Longenecker , George Doherty , Michael L. Curtin , Michael R. Michaelides , Ramzi F. Sweis , Marina A. Pliushchev , Andy Judd , Todd M. Hansen , Howard R. Heyman
IPC: C07D471/04 , A61K45/06 , C07D487/04 , A61K31/4985 , A61K31/437 , A61K31/5377
CPC classification number: A61K31/437 , A61K31/407 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D471/04 , C07D487/04 , A61K2300/00
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
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公开(公告)号：US20130303509A1
公开(公告)日：2013-11-14
申请号：US13891354
申请日：2013-05-10
Applicant: AbbVie Inc.
Inventor： Todd M. Hansen , Kenton Longenecker , Howard R. Heyman , Michael L. Curtin , Richard F. Clark , Bryan Sorensen , Zhiqin Ji , Kevin Woller , George Doherty , Robin Frey
IPC: C07D405/14 , C07D409/14 , A61K31/501 , C07D417/14 , A61K31/496 , A61K31/4545 , A61K31/5377
CPC classification number: A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
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公开(公告)号：US20130303508A1
公开(公告)日：2013-11-14
申请号：US13891349
申请日：2013-05-10
Applicant: AbbVie Inc.
Inventor： Richard F. Clark , Bryan Sorensen , Augustine T. Osuma , Robin Frey , Kenton Longenecker , George Doherty , Michael L. Curtin , Michael R. Michaelides , Ramzi F. Sweis , Marina A. Pliushchev , Andy Judd , Todd M. Hansen , Howard R. Heyman
IPC: C07D471/04 , A61K31/5377 , A61K45/06 , A61K31/496 , A61K31/55 , A61K31/4725 , A61K31/437 , A61K31/4545
CPC classification number: A61K31/437 , A61K31/407 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D471/04 , C07D487/04 , A61K2300/00
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
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公开(公告)号：US09758511B2
公开(公告)日：2017-09-12
申请号：US15048574
申请日：2016-02-19
Applicant: AbbVie Inc.
Inventor： Michael L. Curtin , Kenton Longenecker , Todd M. Hansen , Richard F. Clark , Bryan Sorensen , Howard R. Heyman , Zhiqin Ji
IPC: C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , A61K45/06
CPC classification number: C07D405/14 , A61K45/06 , C07D401/14 , C07D409/14 , C07D417/14
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
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公开(公告)号：US20170135994A9
公开(公告)日：2017-05-18
申请号：US14878858
申请日：2015-10-08
Applicant: AbbVie Inc.
Inventor： Richard F. Clark , Bryan Sorensen , Augustine T. Osuma , Robin Frey , Kenton Longenecker , George Doherty , Michael L. Curtin , Michael Michaelides , Ramzi Sweis , Marina Pliushchev , Andrew Judd , Todd Hansen , Howard R. Heyman
IPC: A61K31/437 , A61K31/4545 , A61K31/496
CPC classification number: A61K31/437 , A61K31/407 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D471/04 , C07D487/04 , A61K2300/00
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
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Patent Agency Ranking
公开(公告)号：US20160184282A1
公开(公告)日：2016-06-30
申请号：US14878858
申请日：2015-10-08
Applicant: AbbVie Inc.
Inventor： Richard F. Clark , Bryan Sorensen , Augustine T. Osuma , Robin Frey , Kenton Longenecker , George Doherty , Michael L. Curtin , Michael Michaelides , Ramzi Sweis , Marina Pliushchev , Andrew Judd , Todd Hansen , Howard R. Heyman
IPC: A61K31/437 , A61K31/4545 , A61K31/496
CPC classification number: A61K31/437 , A61K31/407 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D471/04 , C07D487/04 , A61K2300/00
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
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公开(公告)号：US08975398B2
公开(公告)日：2015-03-10
申请号：US13891357
申请日：2013-05-10
Applicant: AbbVie Inc.
Inventor： Todd M. Hansen , Kenton Longenecker , Howard R. Heyman , Michael L. Curtin , Richard F. Clark , Bryan Sorensen , Zhiqin Ji , Kevin Woller , George Doherty , Robin Frey
IPC: C07D401/00 , C07D405/14 , A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/5377 , C07D409/14 , C07D417/14 , A61K31/506 , C07D401/14 , C07D401/04 , C07D403/04 , C07D403/14
CPC classification number: A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
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![Pyrrolo [2,3-B] pyridine CDK9 kinase inhibitors](/abs-image/US/2017/10/24/US09796708B2/abs.jpg.150x150.jpg)
公开(公告)号：US09796708B2
公开(公告)日：2017-10-24
申请号：US14780018
申请日：2014-03-13
Applicant: AbbVie Inc.
Inventor： Yunsong Tong , Milan Bruncko , Richard F. Clark , Michael Curtin , Alan S. Florjancic , Robin R. Frey , Jianchun Gong , Todd M. Hansen , Zhiqin Ji , Chunqiu Lai , Anthony Mastracchio , Michael Michaelides , Juliem Miyashiro , Roberto M. Risi , Xiaohong Song , Zhi-fu Tao , Keith W. Woods , Guidong Zhu , Thomas Penning , Andrew Souers , Rajeev Goswami , Omprakash Reddy Iguturi , Madhu Babu Dabbeeru
IPC: C07D401/02 , C07D401/10 , A61K31/437 , A61K31/4353 , C07D471/04 , A61K45/06 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/5377
CPC classification number: C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K45/06 , A61K2300/00
Abstract: Disclosed are compounds of Formula (IIa), wherein R1, R2, R3A, R3B, R3C, R3D, R3E, and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (IIa).
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公开(公告)号：US20170065575A1
公开(公告)日：2017-03-09
申请号：US15357383
申请日：2016-11-21
Applicant: AbbVie Inc.
Inventor： Todd M. Hansen , Kenton Longenecker , Howard R. Heyman , Michael L. Curtin , Richard F. Clark , Bryan Sorensen , Zhiqin Ji , Kevin Woller , George Doherty , Robin Frey
IPC: A61K31/4545 , A61K31/506 , A61K31/501 , A61K31/5377 , A61K31/496
CPC classification number: A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
Abstract translation: 公开了抑制NAMPT活性的化合物，含有该化合物的组合物和治疗其中NAMPT表达的疾病的方法。
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公开(公告)号：US20170320880A1
公开(公告)日：2017-11-09
申请号：US15588398
申请日：2017-05-05
Applicant: AbbVie Inc.
Inventor： Michael R. Michaelides , Michael L. Curtin , Huan-Qiu Li , Marina A. Pliushchev , Ying Wang , Hongyu H. Zhao , Richard F. Clark , Alan S. Florjancic , Zhiqin Ji , Mariazel Torrent , Ramzi F. Sweis , Anil Vasudevan , Justin D. Dietrich
IPC: C07D487/04 , C07D417/14 , C07D413/10 , C07D405/04 , C07D403/14 , C07D403/12 , C07D403/10 , C07D403/04 , C07D401/14 , C07D401/12 , C07D401/04 , C07D471/04 , C07D207/14
CPC classification number: C07D487/04 , A61K31/40 , C07D207/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D413/10 , C07D417/14 , C07D471/04
Abstract: Compounds having a structure of Formula (I): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein A1, A2, A3, A4, A5, n, and m are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various EED-related conditions or diseases, including cancer, by administration of such compounds are also provided.
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