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公开(公告)号：US20190247503A1
公开(公告)日：2019-08-15
申请号：US16138486
申请日：2018-09-21
发明人： Steven J. Greenberg , Bernhard K. Mueller , Andreas Popp , Matthew R. Rosebraugh , George M. Haig , Shao-Lee Lin
CPC分类号： A61K45/06 , A61K2039/505 , A61K2039/545 , A61P25/00 , A61P25/28 , C07K16/22 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/76 , C07K2317/94
摘要： Disclosed herein are anti-RGMa antibodies and methods of using these antibodies to treat multiple sclerosis, including relapsing forms of multiple sclerosis such as relapsing-remitting multiple sclerosis or relapsing-secondary progressive multiple sclerosis.
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公开(公告)号：US20180162933A1
公开(公告)日：2018-06-14
申请号：US15832177
申请日：2017-12-05
发明人： Bernhard K. Mueller , Martin Schmidt , Eve Barlow , Mary Leddy , Chung-Ming Hsieh , Philip Bardwell
IPC分类号： C07K16/22 , A61K45/06 , A61K39/395 , A61K39/00
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , Y02A50/466
摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but nor limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.
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公开(公告)号：US20170166633A1
公开(公告)日：2017-06-15
申请号：US15389627
申请日：2016-12-23
发明人： Bernhard K. Mueller , Martin Schmidt , Eve Barlow , Mary Leddy , Chung-Ming Hsieh , Philip Bardwell
IPC分类号： C07K16/22 , A61K45/06 , A61K39/395
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , Y02A50/466
摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but nor limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.
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公开(公告)号：US20170073420A1
公开(公告)日：2017-03-16
申请号：US15261633
申请日：2016-09-09
发明人： Steven J. Greenberg , Bernhard K. Mueller , Andreas Popp , Matthew R. Rosebraugh , George M. Haig , Shao-Lee Lin
IPC分类号： C07K16/28 , A61K45/06 , A61K39/395
CPC分类号： A61K45/06 , A61K2039/505 , A61K2039/545 , A61P25/00 , A61P25/28 , C07K16/22 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/76 , C07K2317/94
摘要： Disclosed herein are anti-RGMa antibodies and methods of using these antibodies to treat multiple sclerosis, including relapsing forms of multiple sclerosis such as relapsing-remitting multiple sclerosis or relapsing-secondary progressive multiple sclerosis.
摘要翻译： 本文公开了抗RGMa抗体和使用这些抗体治疗多发性硬化的方法，包括复发形式的多发性硬化，例如复发性缓解性多发性硬化或复发性继发性进行性多发性硬化症。
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公开(公告)号：US10040852B2
公开(公告)日：2018-08-07
申请号：US14989532
申请日：2016-01-06
发明人： Mario Mezler , Achim Moeller , Reinhold Mueller , Bernhard K. Mueller , Tariq Ghayur , Eve H. Barlow , Martin Schmidt , Axel Meyer , Nicole Teusch
IPC分类号： C07K16/28 , A61K39/395 , C07H21/00 , A61K39/00
摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
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6.发明授权Neutralizing monoclonal antibodies against the Nogo-66 receptor (NgR) and uses thereof 有权针对Nogo-66受体（NgR）的中和单克隆抗体及其用途公开(公告)号：US09255146B2
公开(公告)日：2016-02-09
申请号：US14013916
申请日：2013-08-29
发明人： Mario Mezler , Achim Moeller , Reinhold Mueller , Bernhard K. Mueller , Tariq Ghayur , Eve H. Barlow , Martin Schmidt , Axel Meyer , Nicole Teusch
CPC分类号： C07K16/28 , A61K39/3955 , A61K2039/505 , C07H21/00 , C07K16/2863 , C07K2317/14 , C07K2317/34 , C07K2317/41 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y02A50/466
摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
摘要翻译： 本发明涉及结合Nogo-66受体的分离的蛋白质，特别是单克隆抗体。 具体地说，这些抗体具有抑制Nogo-66受体的天然配体结合并中和Nogo-66受体的能力。 本发明的这些抗体或其部分可用于检测NgR和抑制NgR活性，例如在患有NgR或Nogo-66活性有害的病症的人中。
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7.发明申请公开(公告)号：US20190233510A1
公开(公告)日：2019-08-01
申请号：US16055659
申请日：2018-08-06
发明人： Mario Mezler , Achim Moeller , Reinhold Mueller , Bernhard K. Mueller , Tariq Ghayur , Eve H. Barlow , Martin Schmidt , Axel Meyer , Nicole Teusch
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/28 , A61K39/3955 , A61K2039/505 , C07H21/00 , C07K16/2863 , C07K2317/14 , C07K2317/34 , C07K2317/41 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y02A50/466
摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
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公开(公告)号：US20150183871A1
公开(公告)日：2015-07-02
申请号：US14591445
申请日：2015-01-07
发明人： Bernhard K. Mueller , Martin Schmidt , Eve Barlow , Mary Leddy , Chung-Ming Hsieh , Philip Bardwell
IPC分类号： C07K16/28
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , Y02A50/466
摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but nor limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.
摘要翻译： 本发明涉及结合并中和RGM A蛋白的分离的蛋白质，特别是单克隆抗体。 具体地说，这些抗体具有抑制RGM A与其受体和/或共受体结合的能力。 本发明的这些抗体或其部分可用于检测RGM A和抑制RGM A活性，例如在患有包括但不限于多发性硬化，哺乳动物脑外伤，脊髓损伤，中风，神经变性疾病 和精神分裂症。
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公开(公告)号：US20210230260A1
公开(公告)日：2021-07-29
申请号：US17015442
申请日：2020-09-09
发明人： Bernhard K. Mueller , Martin Schmidt , Eve Barlow , Mary Leddy , Chung-Ming Hsieh , Philip Bardwell
IPC分类号： C07K16/22 , C07K16/28 , A61K39/395 , A61K45/06
摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but nor limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.
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公开(公告)号：US09605069B2
公开(公告)日：2017-03-28
申请号：US14591445
申请日：2015-01-07
发明人： Bernhard K. Mueller , Martin Schmidt , Eve Barlow , Mary Leddy , Chung-Ming Hsieh , Philip Bardwell
IPC分类号： A61K39/395 , C07K16/28 , C07K16/22 , A61K39/00
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , Y02A50/466
摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but nor limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.
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