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公开(公告)号：US20170166633A1
公开(公告)日：2017-06-15
申请号：US15389627
申请日：2016-12-23
发明人： Bernhard K. Mueller , Martin Schmidt , Eve Barlow , Mary Leddy , Chung-Ming Hsieh , Philip Bardwell
IPC分类号： C07K16/22 , A61K45/06 , A61K39/395
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , Y02A50/466
摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but nor limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.
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公开(公告)号：US20180162933A1
公开(公告)日：2018-06-14
申请号：US15832177
申请日：2017-12-05
发明人： Bernhard K. Mueller , Martin Schmidt , Eve Barlow , Mary Leddy , Chung-Ming Hsieh , Philip Bardwell
IPC分类号： C07K16/22 , A61K45/06 , A61K39/395 , A61K39/00
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , Y02A50/466
摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but nor limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.
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公开(公告)号：US20150183871A1
公开(公告)日：2015-07-02
申请号：US14591445
申请日：2015-01-07
发明人： Bernhard K. Mueller , Martin Schmidt , Eve Barlow , Mary Leddy , Chung-Ming Hsieh , Philip Bardwell
IPC分类号： C07K16/28
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , Y02A50/466
摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but nor limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.
摘要翻译： 本发明涉及结合并中和RGM A蛋白的分离的蛋白质，特别是单克隆抗体。 具体地说，这些抗体具有抑制RGM A与其受体和/或共受体结合的能力。 本发明的这些抗体或其部分可用于检测RGM A和抑制RGM A活性，例如在患有包括但不限于多发性硬化，哺乳动物脑外伤，脊髓损伤，中风，神经变性疾病 和精神分裂症。
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公开(公告)号：US20210230260A1
公开(公告)日：2021-07-29
申请号：US17015442
申请日：2020-09-09
发明人： Bernhard K. Mueller , Martin Schmidt , Eve Barlow , Mary Leddy , Chung-Ming Hsieh , Philip Bardwell
IPC分类号： C07K16/22 , C07K16/28 , A61K39/395 , A61K45/06
摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but nor limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.
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公开(公告)号：US09605069B2
公开(公告)日：2017-03-28
申请号：US14591445
申请日：2015-01-07
发明人： Bernhard K. Mueller , Martin Schmidt , Eve Barlow , Mary Leddy , Chung-Ming Hsieh , Philip Bardwell
IPC分类号： A61K39/395 , C07K16/28 , C07K16/22 , A61K39/00
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , Y02A50/466
摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but nor limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.
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公开(公告)号：US20170096470A1
公开(公告)日：2017-04-06
申请号：US15266885
申请日：2016-09-15
申请人： AbbVie, Inc.
发明人： Tariq Ghayur , Philip Bardwell
IPC分类号： C07K14/705 , G01N33/68 , A61K38/17 , C12P21/02
CPC分类号： C07K16/28 , A61K38/177 , A61K38/1774 , A61K39/3955 , A61K45/06 , A61K49/00 , A61K51/1027 , C07K14/70521 , C07K14/70578 , C07K14/7151 , C07K16/22 , C07K16/244 , C07K16/44 , C07K2317/31 , C07K2319/00 , C07K2319/30 , C07K2319/32 , C07K2319/60 , C12P21/02 , G01N33/56972 , G01N33/68 , Y02A50/401 , Y02A50/411
摘要： Engineered multispecific binding proteins that bind at least one ligand for a receptor are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
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7.发明申请METHOD OF PREVENTING OR TREATING ORGAN, HEMATOPOIETIC STEM CELL OR BONE MARROW TRANSPLANT REJECTION 审中-公开预防或治疗器官，HEMATOPOIETIC干细胞或骨髓移植物移植的方法公开(公告)号：US20160175316A1
公开(公告)日：2016-06-23
申请号：US14972983
申请日：2015-12-17
申请人： AbbVie Inc.
发明人： Philip Bardwell , Tariq Ghayur , Jijie Gu , Ingela Beatrice Vikstrom , Andrew Mark Lew , David Matthew Tarlinton , Emma Margarele Carrington , David Ching Siang Huang
IPC分类号： A61K31/5377 , A61K38/13
CPC分类号： A61K31/5377 , A61K31/44 , A61K31/497 , A61K38/13
摘要： Methods of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection are disclosed.
摘要翻译： 公开了预防或治疗器官，造血干细胞或骨髓移植排斥的方法。
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公开(公告)号：US20160101109A1
公开(公告)日：2016-04-14
申请号：US14972429
申请日：2015-12-17
申请人： AbbVie Inc.
发明人： Philip Bardwell , Tariq Ghayur
IPC分类号： A61K31/5377 , A61K45/06 , A61K31/495
CPC分类号： A61K31/5377 , A61K31/495 , A61K31/496 , A61K31/635 , A61K45/06
摘要： Methods of preventing or treating arthritis is disclosed.
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