公开(公告)号：US20220395202A1

公开(公告)日：2022-12-15

申请号：US17818143

申请日：2022-08-08

申请人： ABBOTT DIABETES CARE INC.

发明人： Tianmei OUYANG ,  Benjamin J. FELDMAN

IPC分类号： A61B5/1486

摘要： NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

公开(公告)号：US20230080107A1

公开(公告)日：2023-03-16

申请号：US17819151

申请日：2022-08-11

申请人： Abbott Diabetes Care Inc.

发明人： Tianmei OUYANG ,  Benjamin J. FELDMAN

IPC分类号： C12Q1/00 ,  C12Q1/26 ,  G01N27/327 ,  C12N11/082 ,  G01N33/573 ,  G01N33/66

摘要： NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

公开(公告)号：US20230054564A1

公开(公告)日：2023-02-23

申请号：US17819038

申请日：2022-08-11

申请人： ABBOTT DIABETES CARE INC.

发明人： Tianmei OUYANG ,  Benjamin J. FELDMAN

IPC分类号： C12Q1/00 ,  C12Q1/26 ,  G01N27/327 ,  C12N11/082 ,  G01N33/573 ,  G01N33/66

摘要： NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

公开(公告)号：US20220396820A1

公开(公告)日：2022-12-15

申请号：US17818770

申请日：2022-08-10

申请人： ABBOTT DIABETES CARE INC.

发明人： Tianmei OUYANG ,  Benjamin J. FELDMAN

IPC分类号： C12Q1/00 ,  C12Q1/26 ,  G01N27/327 ,  C12N11/082 ,  G01N33/573 ,  G01N33/66

摘要： NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

公开(公告)号：US20240350047A1

公开(公告)日：2024-10-24

申请号：US18596447

申请日：2024-03-05

申请人： Abbott Diabetes Care Inc.

发明人： Stephen OJA ,  Tianmei OUYANG ,  Hyun CHO ,  Benjamin J. FELDMAN ,  Namvar KIAIE

IPC分类号： A61B5/1486 ,  A61B5/145 ,  C12Q1/00

CPC分类号： A61B5/14865 ,  A61B5/14532 ,  C12Q1/002 ,  C12Q1/005 ,  G01N2333/9029 ,  G01N2333/904 ,  G01N2333/908

摘要： Multiple enzymes may be present in the active area(s) of an electrochemical sensor to facilitate analysis of one or more analytes. The multiple enzymes may function independently to detect several analytes or in concert to detect a single analyte. One sensor configuration includes a first active area and a second active area, where the first active area has an oxidation-reduction potential that is sufficiently separated from the oxidation-reduction potential of the second active area to allow independent signal production. Some sensor configurations may have an active area overcoated with a multi-component membrane containing two or more different membrane polymers. Sensor configurations having multiple enzymes capable of interacting in concert include those in which a first enzyme converts an analyte into a first product and a second enzyme converts the first product into a second product, thereby generating a signal at a working electrode that is proportional to the analyte concentration.

公开(公告)号：US20240279708A1

公开(公告)日：2024-08-22

申请号：US18597714

申请日：2024-03-06

申请人： Abbott Diabetes Care Inc.

发明人： Tianmei OUYANG ,  Cade FOX ,  Zenghe LIU ,  Stephen OJA ,  Benjamin J. FELDMAN

IPC分类号： C12Q1/00 ,  C12Q1/32

CPC分类号： C12Q1/005 ,  C12Q1/32 ,  C12Y101/0103 ,  C12Y112/01002

摘要： The present disclosure provides analyte sensors including one or more NAD(P)-dependent enzymes and an internal supply of NAD(P) for the detection of an analyte. The present disclosure further provides methods of using such analyte sensors for detecting one or more analytes present in a biological sample of a subject, and methods of manufacturing said analyte sensors.

公开(公告)号：US20220389475A1

公开(公告)日：2022-12-08

申请号：US17818912

申请日：2022-08-10

申请人： ABBOTT DIABETES CARE INC.

发明人： Tianmei OUYANG ,  Benjamin J. FELDMAN

IPC分类号： C12Q1/00 ,  C12Q1/26 ,  G01N27/327 ,  C12N11/082 ,  G01N33/573 ,  G01N33/66

摘要： NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

公开(公告)号：US20220338763A1

公开(公告)日：2022-10-27

申请号：US17862303

申请日：2022-07-11

申请人： Abbott Diabetes Care Inc.

发明人： Mark ESHOO ,  Benjamin FELDMAN ,  Tianmei OUYANG ,  Lam TRAN

IPC分类号： A61B5/1473 ,  C12Q1/00 ,  C12Q1/46 ,  A61B5/00 ,  A61B5/1486

摘要： In vivo monitoring devices and systems for enzymes and/or analytes including devices having a reactant reservoir are provided.

公开(公告)号：US20240247297A1

公开(公告)日：2024-07-25

申请号：US18597704

申请日：2024-03-06

申请人： Abbott Diabetes Care Inc.

发明人： Tianmei OUYANG ,  Benjamin J. FELDMAN

IPC分类号： C12Q1/00 ,  A61B5/1486 ,  C12N11/082 ,  C12Q1/26 ,  G01N27/27 ,  G01N27/327 ,  G01N33/573 ,  G01N33/66

CPC分类号： C12Q1/001 ,  A61B5/14865 ,  C12N11/082 ,  C12Q1/004 ,  C12Q1/005 ,  C12Q1/006 ,  C12Q1/26 ,  G01N27/3275 ,  G01N33/5735 ,  G01N33/66 ,  C12Y106/05002 ,  G01N27/27

摘要： NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

公开(公告)号：US20230365758A1

公开(公告)日：2023-11-16

申请号：US18304581

申请日：2023-04-21

申请人： Abbott Diabetes Care Inc.

发明人： Balasubrahmanya S. BOMMAKANTI ,  John V. LATOUR ,  Udo HOSS ,  Tianmei OUYANG ,  Phu LE ,  Gary SANDHU ,  Kevin WALLIS

IPC分类号： C08G81/02 ,  A61B5/145 ,  A61B5/1486 ,  C08G65/333 ,  C08J5/18

CPC分类号： C08G81/025 ,  A61B5/14532 ,  A61B5/14865 ,  C08G65/33317 ,  C08J5/18 ,  A61B5/1495

摘要： Membranes permeable to an analyte may overlay the active sensing region of a sensor to limit the analyte flux and improve the response linearity of the sensor. Temperature variation of the analyte permeability can be problematic in some instances. Polymeric membrane compositions having limited variation in analyte permeability as a function of temperature may comprise: a polymer backbone comprising one or more side chains that comprise a heterocycle; and an amine-free polyether arm appended, via an alkyl spacer or a hydroxy-functionalized alkyl spacer, to the heterocycle of at least a portion of the one or more side chains.