公开(公告)号：US20220205944A1

公开(公告)日：2022-06-30

申请号：US17561505

申请日：2021-12-23

申请人： Abbott Diabetes Care Inc.

发明人： Zenghe LIU ,  Barry S. Kreutz ,  Yagya Raj Ojha ,  Benjamin J. Feldman ,  Thomas P. Leary

IPC分类号： G01N27/327 ,  C12N9/06 ,  C12N9/82

摘要： The present disclosure provides an analyte sensor for use in detecting aspartate and/or asparagine. In certain embodiments, an aspartate-responsive active site of a presently disclosed analyte sensor includes an aspartate oxidase disposed upon a surface of a working electrode. In certain embodiments, an asparagine-responsive active site of a presently disclosed analyte sensor includes an enzyme system comprising an aspartate oxidase and an asparaginase disposed upon a surface of a working electrode. The present disclosure further provides methods for detecting aspartate and/or asparagine using the disclosed analyte sensors.

公开(公告)号：US20230248271A1

公开(公告)日：2023-08-10

申请号：US18009472

申请日：2021-05-13

申请人： Abbott Diabetes Care Inc.

发明人： Zenghe LIU ,  Cade B. FOX ,  Jonathan D. MCCANLESS ,  Benjamin J. FELDMAN

IPC分类号： A61B5/145

CPC分类号： A61B5/14532 ,  A61B5/14546 ,  A61B5/14865

摘要： Analyte sensors are being increasingly employed for monitoring various analytes in vivo. Analyte sensors configured to monitor multiple analytes are also in development. Sufficient sensitivity for low-abundance analytes and multiple analytes having differing membrane permeability values may complicate analyte detection in some cases. Analyte sensors may feature enhancements to address one or both of these issues. Some analyte sensors may comprise a carbon working electrode comprising a dielectric substrate, one or more apertures extending through the dielectric substrate and filled with a carbon conductor pillar, a carbon conductor coating on a first face of the dielectric substrate in direct contact with each carbon conductor pillar, and one or more active areas on a second face of the dielectric substrate in electrical communication with the carbon conductor pillars. Photopolymerized mass transport limiting membranes may be used in combination with such carbon working electrodes or with other working electrode types.

公开(公告)号：US20240279708A1

公开(公告)日：2024-08-22

申请号：US18597714

申请日：2024-03-06

申请人： Abbott Diabetes Care Inc.

发明人： Tianmei OUYANG ,  Cade FOX ,  Zenghe LIU ,  Stephen OJA ,  Benjamin J. FELDMAN

IPC分类号： C12Q1/00 ,  C12Q1/32

CPC分类号： C12Q1/005 ,  C12Q1/32 ,  C12Y101/0103 ,  C12Y112/01002

摘要： The present disclosure provides analyte sensors including one or more NAD(P)-dependent enzymes and an internal supply of NAD(P) for the detection of an analyte. The present disclosure further provides methods of using such analyte sensors for detecting one or more analytes present in a biological sample of a subject, and methods of manufacturing said analyte sensors.

公开(公告)号：US20240268722A1

公开(公告)日：2024-08-15

申请号：US18624925

申请日：2024-04-02

申请人： Abbott Diabetes Care Inc.

发明人： Udo HOSS ,  Benjamin J. FELDMAN ,  Zenghe LIU ,  Hyun CHO ,  Benjamin M. RUSH

IPC分类号： A61B5/1473 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1468

CPC分类号： A61B5/1473 ,  A61B5/14532 ,  A61B5/7275 ,  A61B5/7405 ,  A61B5/742 ,  A61B5/7455 ,  A61B5/1451 ,  A61B5/1468 ,  A61B2560/0252 ,  A61B2560/0443

摘要： Method and system for determining real time analyte concentration including an analyte sensor having a portion in fluid contact with an interstitial fluid under a skin layer, an on-body electronics including a housing coupled to the analyte sensor and configured for positioning on the skin layer, the on-body electronics housing including a plurality of electrical contacts, on the housing; and a data analysis unit having a data analysis unit housing and a plurality of probes, on the housing. Each of the probes configured to electrically couple to a respective electrical contact when the data analysis unit is positioned in physical contact with the on-body electronics. The one or more signals on the probes correspond to one or more of a substantially real time monitored analyte concentration level (MACL), MACL over a predetermined time period, or a rate of change of the MACL, or combinations thereof, are provided.

公开(公告)号：US20220386906A1

公开(公告)日：2022-12-08

申请号：US17817782

申请日：2022-08-05

申请人： Abbott Diabetes Care, Inc.

发明人： Tianmei OUYANG ,  Zenghe LIU ,  Hyun CHO ,  Benjamin J. FELDMAN

IPC分类号： A61B5/145 ,  A61B5/1486 ,  A61B5/1473 ,  A61B5/1477

摘要： An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.