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公开(公告)号：US20200256843A1
公开(公告)日：2020-08-13
申请号：US16864672
申请日：2020-05-01
申请人： ABBOTT LABORATORIES
发明人： Jeffrey B. Huff , Mark A. Hayden , Peter J. Karabatsos , Andrew S. Schapals , Anthony S. Muerhoff , M. Felicia Bogdan , Thomas Leary , Shelley R. Holets-McCormack , Sophie Laurenson , Andrew T. Fischer , Richard Haack , Stefan Hershberger , Dustin House , Lei Qiao , M. Shawn Murphy , Mark R. Pope , Edna M. Prieto-Ballengee , QiaoQiao Ruan , Pathik Soni , Sergey Tetin , Lyle Yarnell
IPC分类号： G01N33/487 , G01N33/53 , B01L3/00 , G01N33/543
摘要： Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided.
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2.发明授权公开(公告)号：US11065352B2
公开(公告)日：2021-07-20
申请号：US15851199
申请日：2017-12-21
申请人： Abbott Laboratories
发明人： Patrick Fritchie , Pathik Soni , Lei Qiao , Dustin House , Lyle Yarnell , Edna Prieto-Ballengee , Cathy Forsythe , Michael Shawn Murphy , Andrew Fischer , Akanksha Sharma , Joseph Esposito , Matt Effinger , Michael Futer
摘要： Inductive heating systems and method of controlling the same to reduce biological carryover are disclosed herein. An example system includes an induction heater including a tank circuit. The example system includes a controller to drive the tank circuit to selectively oscillate at a resonant frequency for the tank circuit to inductively heat a work piece disposed proximate to the tank circuit.
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3.发明申请公开(公告)号：US20180193498A1
公开(公告)日：2018-07-12
申请号：US15851199
申请日：2017-12-21
申请人： Abbott Laboratories
发明人： Patrick Fritchie , Pathik Soni , Lei Qiao , Dustin House , Lyle Yarnell , Edna Prieto-Ballengee , Cathy Forsythe , Michael Shawn Murphy , Andrew Fischer , Akanksha Sharma , Joseph Esposito , Matt Effinger , Michael Futer
摘要： Inductive heating systems and method of controlling the same to reduce biological carryover are disclosed herein. An example system includes an induction heater including a tank circuit. The example system includes a controller to drive the tank circuit to selectively oscillate at a resonant frequency for the tank circuit to inductively heat a work piece disposed proximate to the tank circuit.
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公开(公告)号：US11022598B2
公开(公告)日：2021-06-01
申请号：US15724213
申请日：2017-10-03
申请人： ABBOTT LABORATORIES
发明人： Jeffrey B. Huff , Mark A. Hayden , Peter J. Karabatsos , Andrew S. Schapals , Anthony S. Muerhoff , M. Felicia Bogdan , Thomas Leary , Shelley R. Holets-McCormack , Sophie Laurenson , Andrew T. Fischer , Richard Haack , Stefan Hershberger , Dustin House , Lei Qiao , M. Shawn Murphy , Mark R. Pope , Edna M. Prieto-Ballengee , QiaoQiao Ruan , Pathik Soni , Sergey Tetin , Lyle Yarnell
IPC分类号： G01N33/487 , G01N33/543 , G01N33/53 , B01L3/00
摘要： Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided.
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公开(公告)号：US20180095067A1
公开(公告)日：2018-04-05
申请号：US15724200
申请日：2017-10-03
申请人： Abbott Laboratories
发明人： Jeffrey B. Huff , Mark A. Hayden , Peter J. Karabatsos , Andrew S. Schapals , Anthony S. Muerhoff , Felicia Bogdan , Thomas Leary , Shelley R. Holets-McCormack , Sophie Laurenson , Andrew T. Fischer , Richard Haack , Stefan Hershberger , Dustin House , Lei QIAO , M. Shawn Murphy , Mark R. Pope , Edna M. Prieto-Ballengee , QiaoQiao Ruan , Pathik Soni , Sergey Tetin , Lyle Yarnell , John M. Robinson
IPC分类号： G01N33/487 , G01N33/53
CPC分类号： G01N33/48721 , G01N33/5302 , G01N33/54326 , G01N33/5438
摘要： Integrated microfluidic and analyte detection devices are disclosed, along with methods of detecting target analytes. Digital microfluidic and analyte detection devices include a first substrate and a second substrate aligned generally parallel to each other to define a gap therebetween, the first substrate including a plurality of electrodes to generate electrical actuation forces on a liquid droplet disposed in the gap; at least one reagent disposed on at least one of the first substrate or the second substrate and configured to be carried by the liquid droplet; and an analyte detection device in fluid communication with the gap, wherein the plurality of electrodes are configured to move the liquid droplet towards the analyte detection device.
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6.发明申请公开(公告)号：US20210338856A1
公开(公告)日：2021-11-04
申请号：US17375737
申请日：2021-07-14
申请人： Abbott Laboratories
发明人： Patrick Fritchie , Pathik Soni , Lei Qiao , Dustin House , Lyle Yarnell , Edna Prieto-Ballengee , Cathy Forsythe , Michael Shawn Murphy , Andrew Fischer , Akanksha Sharma , Joseph Esposito , Matt Effinger , Michael Futer
摘要： Inductive heating systems and method of controlling the same to reduce biological carryover are disclosed herein. An example system includes an induction heater including a tank circuit, the tank circuit including a work coil and a sense coil. The sense coil is to detect a magnetic field generated by the work coil and to output signals in response to the detection. The example system includes a controller to cause the tank circuit to oscillate at a resonant frequency in response to the signals and a power drive unit in communication with the controller and the induction heater. The power drive unit is to adjust power provided to the induction heater in response to the controller driving the tank circuit to oscillate at the resonant frequency.
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公开(公告)号：US20180188230A1
公开(公告)日：2018-07-05
申请号：US15724213
申请日：2017-10-03
申请人： ABBOTT LABORATORIES
发明人： Jeffrey B. Huff , Mark A. Hayden , Peter J. Karabatsos , Andrew S. Schapals , Anthony S. Muerhoff , Felicia Bogdan , Thomas Leary , Shelley R. Holets-McCormack , Sophie Laurenson , Andrew T. Fischer , Richard Haack , Stefan Hershberger , Dustin House , Lei Qiao , M. Shawn Murphy , Mark R. Pope , Edna M. Prieto-Ballengee , QiaoQiao Ruan , Pathik Soni , Sergey Tetin , Lyle Yarnell
IPC分类号： G01N33/487 , G01N33/543 , B01L3/00
CPC分类号： G01N33/48721 , B01L3/502761 , B01L2300/0645 , B01L2400/0406 , G01N33/5308 , G01N33/54306 , G01N2458/10
摘要： Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided.
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